Ignet

Gene Information

Gene symbol: IL1R2

Gene name: interleukin 1 receptor, type II

HGNC ID: 5994

Synonyms: CD121b

Related Genes

#	Gene Symbol	Number of hits
1	BCL2	1 hits
2	ICOSLG	1 hits
3	IL10	1 hits
4	IL12B	1 hits
5	IL1B	1 hits
6	IL1R1	1 hits
7	IL1RAPL2	1 hits
8	IL23A	1 hits
9	IL23R	1 hits
10	IL6	1 hits
11	JAK2	1 hits
12	NKX2-3	1 hits
13	ORMDL3	1 hits
14	REL	1 hits
15	SLC11A1	1 hits
16	SMAD3	1 hits
17	STAT1	1 hits
18	STAT3	1 hits
19	STAT4	1 hits
20	TYK2	1 hits

Related Sentences

#	PMID	Sentence
1	11016460	NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.
2	11016460	This locus was designated Idd5 and encompassed candidate genes including Il1r1, Il1r2, Stat1, Stat4, Nramp1, and Bcl2.
3	11016460	Idd5.1 is in the proximal 1.5-cM portion of the interval and contains the candidates Casp8, Cflar (FLIP), Cd28, and Cd152 (CTLA4).
4	11016460	Idd5.2 is in the distal 5.1-cM portion of the 9.4-cM interval and contains the candidates Nramp1, which has a functional polymorphism between NOD and B10, and Cmkar2 (CXCR2, interleukin [IL]-8 receptor alpha).
5	11016460	Candidate genes eliminated by this analysis include Il1r1, Ilr2, Zap70, Orch5, Stat1, Stat4, Bcl2, Cmkar4 (CXCR4), and Il10.
6	15814729	Importantly, IL-1R antagonist and type 2 IL-1 receptor (IL-1R2) failed to up-regulate in response to LPS in db/db mice.
7	16217019	Here we report that peripherally administered insulin-like growth factor 1 (IGF-1) attenuates LPS-dependent depression of social exploration (sickness) in nondiabetic (db/+) but not in diabetic (db/db) mice.
8	16217019	We show that the insulin/IGF-1 mimetic vanadyl sulfate (VS) is effective at augmenting recovery from sickness in both db/+ and db/db mice.
9	16217019	Examination of the mechanism of VS action in db/+ mice showed that VS paradoxically augmented peritoneal macrophage responsivity to LPS, increasing both peritoneal and ex vivo macrophage production of IL-1beta and IL-6 but not TNF-alpha.
10	16217019	VS also inhibited LPS-dependent up-regulation of IL-1beta and IL-6 mRNA in the brain, while increasing by 50% the cerebral expression of transcripts of the specific antagonist of IL-1 receptors IL-1RA and IL-1R2.
11	21300624	Amongst these are multiple genes involved in IL23/Th17 signalling (IL23R, IL12B, JAK2, TYK2 and STAT3), IL10, IL1R2, REL, CARD9, NKX2.3, ICOSLG, PRDM1, SMAD3 and ORMDL3.
12	21300624	For Crohn's disease, defective processing of intracellular bacteria has become a central theme, following gene discoveries in autophagy and innate immunity (associations with NOD2, IRGM, ATG16L1 are specific to Crohn's disease).
13	21300624	Genetic evidence has also demonstrated the importance of barrier function to the development of ulcerative colitis (HNF4A, LAMB1, CDH1 and GNA12).