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Gene Information
Gene symbol: IL27
Gene name: interleukin 27
HGNC ID: 19157
Synonyms: IL-27, p28, IL27p28, IL-27A, IL27A, MGC71873
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | C19orf10 | 1 hits |
| 2 | CD69 | 1 hits |
| 3 | EBI3 | 1 hits |
| 4 | GLIS3 | 1 hits |
| 5 | IL10 | 1 hits |
| 6 | IL17B | 1 hits |
| 7 | IL18RAP | 1 hits |
| 8 | IL19 | 1 hits |
| 9 | IL20 | 1 hits |
| 10 | IL27RA | 1 hits |
| 11 | IL3 | 1 hits |
| 12 | PTPN22 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18230955 | They are clustered into three groups: noxious (the 'bad', 8 members), comprising IL-1, IL-2, IL-6, IL-7, IL-8, IL-15, IL-17 and IL-18; protective (the 'good', 5 members), comprising IL-4, IL-10, IL-11, IL-12 and IL-13; and 'aloof' , comprising IL-5, IL-9, IL-14, IL-16 and IL-19 through IL-29 (15 members). |
| 2 | 18230955 | IL-3 was reluctant to clustering and IL-30 through 33 were not included due to the scarce available data. |
| 3 | 19430480 | The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27. |
| 4 | 20176734 | We identified multiple previously unreported or unconfirmed disease associations, including known CD loci (ICOSLG and TNFSF15) and T1D loci (TNFAIP3) that confer UC risk, known UC loci (HERC2 and IL26) that confer T1D risk and known UC loci (IL10 and CCNY) that confer CD risk. |
| 5 | 20176734 | Additionally, we show that T1D risk alleles residing at the PTPN22, IL27, IL18RAP and IL10 loci protect against CD. |
| 6 | 21925473 | IL-27, a cytokine consisting of IL-27p28 and Epstein-Barr virus-induced gene 3 (EBI3), binds a membrane-bound heterodimeric receptor consisting of the IL-27 receptor α chain (WSX-1) and gp130. |
| 7 | 21925473 | We evaluated blood glucose and islet proinsulin concentrations, inflammatory cell infiltration in islets, and expression of IL-1β mRNA in pancreas in wild-type (WT), EBI3(-/-), and WSX-1(-/-) mice treated with streptozotocin (STZ). |
| 8 | 21925473 | Hyperglycemia was augmented in EBI3(-/-) and WSX-1(-/-) mice compared with WT mice. |
| 9 | 21925473 | Islet proinsulin levels after STZ treatment were lower in EBI3(-/-) and WSX-1(-/-) mice than in WT mice. |
| 10 | 21925473 | The infiltration of islets by F4/80(+)CD11c(-)7/4(-) macrophages, CD4(+) T cells, and CD8(+) T cells was increased in EBI3(-/-) and WSX-1(-/-) mice compared with WT mice. |
| 11 | 21925473 | The administration of recombinant IL-27, compared with control, decreased the blood glucose level, immune cell infiltration into islets, and IL-1β mRNA expression in the pancreas and increased islet proinsulin levels in WT and EBI3(-/-) mice. |