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Gene Information
Gene symbol: IMPDH2
Gene name: IMP (inosine 5'-monophosphate) dehydrogenase 2
HGNC ID: 6053
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BRAP | 1 hits |
| 2 | CBS | 1 hits |
| 3 | CLCN2 | 1 hits |
| 4 | PRKAA1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14722619 | However, their importance was underlined by findings that mutations in conserved residues within them cause a variety of human hereditary diseases, including (with the gene mutated in parentheses): Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase); retinitis pigmentosa (IMP dehydrogenase-1); congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members); and homocystinuria (cystathionine beta-synthase). |
| 2 | 14722619 | We now show that tandem pairs of CBS domains from AMP-activated protein kinase, IMP dehydrogenase-2, the chloride channel CLC2, and cystathionine beta-synthase bind AMP, ATP, or S-adenosyl methionine,while mutations that cause hereditary diseases impair this binding. |