Ignet

Gene Information

Gene symbol: IRF7

Gene name: interferon regulatory factor 7

HGNC ID: 6122

Related Genes

#	Gene Symbol	Number of hits
1	AHSA1	1 hits
2	CCL5	1 hits
3	CELIAC3	1 hits
4	CTLA4	1 hits
5	CXCL10	1 hits
6	DDX58	1 hits
7	FAS	1 hits
8	FOXP3	1 hits
9	FUS	1 hits
10	IFIH1	1 hits
11	IFNA1	1 hits
12	IFNG	1 hits
13	IL15	1 hits
14	INS	1 hits
15	IRF3	1 hits
16	MYD88	1 hits
17	NFKB1	1 hits
18	NOS2A	1 hits
19	RIPK1	1 hits
20	STAT1	1 hits
21	TLR8	1 hits
22	TLR9	1 hits

Related Sentences

#	PMID	Sentence
1	17130537	To address DC dysregulation we examined kinetic global gene expression in NOD and B6 GM-CSF/IL-4-induced bone marrow-derived DC following lipopolysaccharide (LPS)-stimulation.
2	17130537	Mechanistically, heightened IFN-alpha/beta responses were not due to increased production of this cytokine, IFN-gamma priming or increased Syk kinase activity.
3	17130537	We found, however, heightened responses to IFN-alpha/beta in NOD versus B6 as demonstrated by increased type 1 IFN target gene expression, for example, IRF-7, in NOD DC and macrophages.
4	21490291	The mRNA expression levels of CCL20, CXCL8, and CXCL10 chemokines were determined by qRT-PCR.
5	21490291	TLR7 and TLR9 expression levels were induced 4.2- and 9-fold, respectively, whereas other TLR and nucleotide-binding oligomerization domain receptors were not modified.
6	21490291	Increased levels of IFN type 1 and IFN regulators Stat1 and IRF7 followed the upregulation of TLR9.
7	21490291	Activation of TLR9 was also evidenced by increased Frizzled 5 expression in Ljo-treated Caco-2 cells and an increase in the number of Paneth cells in Ljo-fed, diabetes-prone rats.
8	21805019	The sensing of ribonucleic acids (RNAs) by the monocyte/macrophage system occurs through the TLR7/8 Toll-like receptor family, the retinoic acid-inducible protein I (RIG-I), and the melanoma differentiation-associated protein-5 (MDA-5).
9	21805019	To determine whether circulating RNAs have an agonistic or antagonistic effect on the signaling pathways involved in inflammatory, apoptotic, and antiviral cascade, their effect on TLR8, RIG-I, MDA-5, MyD88, NF-KB, IRF-3, phosphoIRF-3, IRF-7, RIP, and p38 was evaluated.
10	21805019	A significantly lower level was achieved by cultivating PBMCs with circulating RNAs isolated from type 1 diabetic children, compared to the intact PBMCs, in relation to TLR-8, MDA-5, NF-KB, phospho IRF-3, and RIP, while it was higher for Bax.
11	21805019	All the metabolic stress conditions up-regulated NF-KB, Bcl-2, and Bax.
12	22653339	We presently observed that CHOP knockdown (KD) prevents cytokine-mediated degradation of the anti-apoptotic proteins B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1), thereby decreasing the cleavage of executioner caspases 9 and 3, and apoptosis.
13	22653339	CHOP KD resulted in reduced cytokine-induced NF-κB activity and expression of key NF-κB target genes involved in apoptosis and inflammation, including iNOS, FAS, IRF-7, IL-15, CCL5 and CXCL10.
14	23490285	We first noted a significant reduction for Foxp3 and CTLA4 expression levels in PBMCs of FT1D patients.
15	23490285	Therefore, ectopic IRF-7 expression significantly promoted Foxp3 and CTLA4 expression in PBMCs, while knockdown of IRF-7 manifested opposite effect.
16	23695216	Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance.
17	23695216	KO of IRF7 improved glucose and lipid homeostasis and insulin sensitivity.
18	23695216	This study demonstrates a role for IRF7 in diet-induced alterations in energy metabolism and insulin sensitivity.
19	23695216	Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance.
20	23695216	KO of IRF7 improved glucose and lipid homeostasis and insulin sensitivity.
21	23695216	This study demonstrates a role for IRF7 in diet-induced alterations in energy metabolism and insulin sensitivity.
22	23695216	Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance.
23	23695216	KO of IRF7 improved glucose and lipid homeostasis and insulin sensitivity.
24	23695216	This study demonstrates a role for IRF7 in diet-induced alterations in energy metabolism and insulin sensitivity.