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Gene Information
Gene symbol: ITGA1
Gene name: integrin, alpha 1
HGNC ID: 6134
Synonyms: VLA1, CD49a
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATF3 | 1 hits |
| 2 | CDK2 | 1 hits |
| 3 | CDK4 | 1 hits |
| 4 | COL1A1 | 1 hits |
| 5 | ITGA4 | 1 hits |
| 6 | ITGA5 | 1 hits |
| 7 | ITGAM | 1 hits |
| 8 | ITGB1 | 1 hits |
| 9 | ITGB2 | 1 hits |
| 10 | KDR | 1 hits |
| 11 | MMP13 | 1 hits |
| 12 | SERPINE1 | 1 hits |
| 13 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15277376 | Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin. |
| 2 | 15277376 | Monocytes of type 1 diabetic patients displayed an increased adhesion to fibronectin in comparison with type 2 patients and healthy control subjects but had a normal expression of the FN binding integrins CD29, CD49a, CD49d, and CD49e (although CD11b and CD18 expression was increased). |
| 3 | 15277376 | MRP-8/14, which was increased in the sera of type 1 diabetic patients, induced healthy donor monocytes to adhere to FN and upregulate CD11b expression in a dosage-dependent manner. |
| 4 | 16428460 | Anti-ATF3 small interfering RNA gave an inhibitory influence on tube formation by NP31 cells expressing an activated form of the vascular endothelial growth factor receptor 1 (VEGFR-1) kinase. |
| 5 | 16428460 | While ATF3 failed to induce expressions of VEGF and VEGFR, it regulated those of CDK2, CDK4, p8, plasminogen activator inhibitor 1, integrin alpha1, subunit and matrix metalloprotease MMP13. |
| 6 | 16428460 | In H2O2-stimulated NP31 cells as well as endothelial cells of glomerulus and aorta of Otsuka-Long-Evans-Tokushima-Fatty diabetic model rats, concomitantly enhanced expressions of ATF3, PAI-1, and p8 were observed. |
| 7 | 16775606 | Excessive glomerular collagen IV and reactive oxygen species (ROS) production are key factors in the development of diabetic nephropathy. |
| 8 | 16775606 | Integrin alpha1beta1, the major collagen IV receptor, dowregulates collagen IV and ROS production, suggesting this integrin might determine the severity of diabetic nephropathy. |
| 9 | 16775606 | To test this possibility, wild-type and integrin alpha1-null mice were rendered diabetic with streptozotocin (STZ) (100 mg/kg single intraperitoneal injection), after which glomerular filtration rate (GFR), glomerular collagen deposition, and glomerular basement membrane (GBM) thickening were evaluated. |
| 10 | 16775606 | In addition, ROS and collagen IV production by mesangial cells as well as their proliferation was measured in vitro. |
| 11 | 16775606 | Diabetic mutant mice also showed increased glomerular deposition of collagen IV and GBM thickening compared to diabetic wild-type mice. |
| 12 | 16775606 | Primary alpha1-null mesangial cells exposed to high glucose produced more ROS than wild-type cells, which led to decreased proliferation and increased collagen IV synthesis, thus mimicking the in vivo finding. |