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Gene Information
Gene symbol: KCNC1
Gene name: potassium voltage-gated channel, Shaw-related subfamily, member 1
HGNC ID: 6233
Synonyms: Kv3.1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | KCNA5 | 1 hits |
| 2 | KCNB1 | 1 hits |
| 3 | KCNB2 | 1 hits |
| 4 | KCNC2 | 1 hits |
| 5 | KCND2 | 1 hits |
| 6 | KCNG1 | 1 hits |
| 7 | KCNG2 | 1 hits |
| 8 | KCNH2 | 1 hits |
| 9 | KCNIP3 | 1 hits |
| 10 | KCNS3 | 1 hits |
| 11 | RP9 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14988243 | Cell-specific markers were used to show that Kv2.1, Kv3.2, Kv6.2, and Kv9.3 are expressed in beta-cells, that Kv3.1 and Kv6.1 are expressed in alpha-cells, and that Kv2.2 is expressed in delta-cells. |
| 2 | 21147063 | Expression and high glucose-mediated regulation of K+ channel interacting protein 3 (KChIP3) and KV4 channels in retinal Müller glial cells. |
| 3 | 16099841 | Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. |
| 4 | 16099841 | Unfortunately, none of the existing small-molecule Kv1.3 blockers is selective, and many of them, such as correolide, 4-phenyl-4-[3-(methoxyphenyl)-3-oxo-2-azapropyl]cyclohexanone, and our own compound Psora-4 inhibit the cardiac K+ channel Kv1.5. |
| 5 | 16099841 | By further exploring the structure-activity relationship around Psora-4 through a combination of traditional medicinal chemistry and whole-cell patch-clamp, we identified a series of new phenoxyalkoxypsoralens that exhibit 2- to 50-fold selectivity for Kv1.3 over Kv1.5, depending on their exact substitution pattern. |
| 6 | 16099841 | The most potent and "drug-like" compound of this series, 5-(4-phenoxybutoxy)psoralen (PAP-1), blocks Kv1.3 in a use-dependent manner, with a Hill coefficient of 2 and an EC50 of 2 nM, by preferentially binding to the C-type inactivated state of the channel. |
| 7 | 16099841 | PAP-1 is 23-fold selective over Kv1.5, 33- to 125-fold selective over other Kv1-family channels, and 500- to 7500-fold selective over Kv2.1, Kv3.1, Kv3.2, Kv4.2, HERG, calcium-activated K+ channels, Na+,Ca2+, and Cl- channels. |
| 8 | 16099841 | PAP-1 does not exhibit cytotoxic or phototoxic effects, is negative in the Ames test, and affects cytochrome P450-dependent enzymes only at micromolar concentrations. |
| 9 | 16099841 | PAP-1 and several of its derivatives therefore constitute excellent new tools to further explore Kv1.3 as a target for immunosuppression and could potentially be developed into orally available immunomodulators. |