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Gene Information
Gene symbol: KCNJ5
Gene name: potassium inwardly-rectifying channel, subfamily J, member 5
HGNC ID: 6266
Synonyms: Kir3.4, CIR, KATP1, GIRK4, LQT13
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABCC8 | 1 hits |
| 2 | KCNJ1 | 1 hits |
| 3 | KCNJ11 | 1 hits |
| 4 | KCNJ13 | 1 hits |
| 5 | KCNJ2 | 1 hits |
| 6 | KCNJ3 | 1 hits |
| 7 | KCNJ6 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7729621 | We screened a hamster insulinoma cDNA library by low-stringency hybridization with a probe coding for the G-protein-coupled inwardly rectifying K+ channel GIRK1/KGA and isolated clones encoding a protein, KATP-2, whose sequence is 90% similar to that of the recently described KATP-1, an ATP-sensitive K+ channel expressed in heart and other tissues. |
| 2 | 15980413 | In this study, we show that in contrast to their stimulatory effect on K(ATP) channels, LC-CoA (e.g. oleoyl-CoA) potently and reversibly inhibits all other Kir channels tested (Kir1.1, Kir2.1, Kir3.4, Kir7.1). |
| 3 | 15980413 | Biochemical studies also demonstrate that PIP2 and LC-CoA bind with similar affinity to the C-terminal domains of Kir2.1 and Kir6.2 and that PIP2 binding can be competitively antagonized by LC-CoA, suggesting that the mechanism of LC-CoA inhibition involves displacement of PIP2. |
| 4 | 15980413 | Furthermore, we demonstrate that in contrast to its stimulatory effect on K(ATP) channels, phosphatidylinositol 3,4-bisphosphate has an inhibitory effect on Kir1.1 and Kir2.1. |
| 5 | 17431820 | One of them is the cardiac ATP-sensitive potassium channel (K(ATP)), which is an octamer composed of four pore-forming inwardly rectifying potassium-channel subunits (Kir6.2) and four regulatory sulfonylurea-receptor subunits (SUR2A). |