Ignet

Gene Information

Gene symbol: KHK

Gene name: ketohexokinase (fructokinase)

HGNC ID: 6315

Related Genes

#	Gene Symbol	Number of hits
1	AKR1B1	1 hits
2	G6PD	1 hits
3	GCK	1 hits
4	GCKR	1 hits
5	MLXIPL	1 hits
6	SH3PXD2A	1 hits
7	SORD	1 hits
8	XDH	1 hits

Related Sentences

#	PMID	Sentence
1	2984623	Several modifications in the currently available techniques were made in order to localize glucose-6-phosphate dehydrogenase, aldose reductase, sorbitol dehydrogenase, hexokinase and ketohexokinase in ocular lens.
2	2984623	Aldose reductase activity increased in hypermature and senile diabetic cataracts, whereas sorbitol dehydrogenase activity decreased in these lenses.
3	2984623	Similarly, in alloxan-diabetic rat lenses the activity of aldose reductase increased while that of sorbitol dehydrogenase decreased with the prolongation of diabetes.
4	8662230	Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23.
5	8662230	The role of glucokinase (GCK) as pancreatic beta cell glucose sensor and the finding of GCK mutations in maturity onset diabetes of the young (MODY) suggest GCKR as a further candidate gene for type 2 diabetes.
6	8662230	The inhibition of GCK by GCKR is relieved by the binding of fructose-1-phosphate (F-1-P) to GCKR.
7	8662230	F-1-P is the end product of ketohexokinase (KHK, fructokinase), which, like GCK and GCKR, is present in both liver and pancreatic islet.
8	8662230	We have isolated genomic clones containing the human GCKR and KHK genes.
9	8662230	By fluorescent in situ hybridization (FISH), KHK maps to Chromosome (Chr) 2p23.2-23.3, a new assignment corroborated by somatic cell hybrid analysis.
10	8662230	The localization of GCKR, originally reported by others as 2p22.3, has been reassessed by high-resolution FISH, indicating that, like KHK, GCKR maps to 2p23.2-23.3.
11	8662230	The proximity of GCKR and KHK was further demonstrated both by two-color interphase FISH, which suggests that the two genes lie within 500 kb of each other, and by analysis of overlapping YAC and P1 clones spanning the interval between GCKR and KHK.
12	8662230	It also raises the possibility of coordinate regulation of GCKR and KHK by common cis-acting regulatory elements.
13	8662230	Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23.
14	8662230	The role of glucokinase (GCK) as pancreatic beta cell glucose sensor and the finding of GCK mutations in maturity onset diabetes of the young (MODY) suggest GCKR as a further candidate gene for type 2 diabetes.
15	8662230	The inhibition of GCK by GCKR is relieved by the binding of fructose-1-phosphate (F-1-P) to GCKR.
16	8662230	F-1-P is the end product of ketohexokinase (KHK, fructokinase), which, like GCK and GCKR, is present in both liver and pancreatic islet.
17	8662230	We have isolated genomic clones containing the human GCKR and KHK genes.
18	8662230	By fluorescent in situ hybridization (FISH), KHK maps to Chromosome (Chr) 2p23.2-23.3, a new assignment corroborated by somatic cell hybrid analysis.
19	8662230	The localization of GCKR, originally reported by others as 2p22.3, has been reassessed by high-resolution FISH, indicating that, like KHK, GCKR maps to 2p23.2-23.3.
20	8662230	The proximity of GCKR and KHK was further demonstrated both by two-color interphase FISH, which suggests that the two genes lie within 500 kb of each other, and by analysis of overlapping YAC and P1 clones spanning the interval between GCKR and KHK.
21	8662230	It also raises the possibility of coordinate regulation of GCKR and KHK by common cis-acting regulatory elements.
22	8662230	Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23.
23	8662230	The role of glucokinase (GCK) as pancreatic beta cell glucose sensor and the finding of GCK mutations in maturity onset diabetes of the young (MODY) suggest GCKR as a further candidate gene for type 2 diabetes.
24	8662230	The inhibition of GCK by GCKR is relieved by the binding of fructose-1-phosphate (F-1-P) to GCKR.
25	8662230	F-1-P is the end product of ketohexokinase (KHK, fructokinase), which, like GCK and GCKR, is present in both liver and pancreatic islet.
26	8662230	We have isolated genomic clones containing the human GCKR and KHK genes.
27	8662230	By fluorescent in situ hybridization (FISH), KHK maps to Chromosome (Chr) 2p23.2-23.3, a new assignment corroborated by somatic cell hybrid analysis.
28	8662230	The localization of GCKR, originally reported by others as 2p22.3, has been reassessed by high-resolution FISH, indicating that, like KHK, GCKR maps to 2p23.2-23.3.
29	8662230	The proximity of GCKR and KHK was further demonstrated both by two-color interphase FISH, which suggests that the two genes lie within 500 kb of each other, and by analysis of overlapping YAC and P1 clones spanning the interval between GCKR and KHK.
30	8662230	It also raises the possibility of coordinate regulation of GCKR and KHK by common cis-acting regulatory elements.
31	8662230	Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23.
32	8662230	The role of glucokinase (GCK) as pancreatic beta cell glucose sensor and the finding of GCK mutations in maturity onset diabetes of the young (MODY) suggest GCKR as a further candidate gene for type 2 diabetes.
33	8662230	The inhibition of GCK by GCKR is relieved by the binding of fructose-1-phosphate (F-1-P) to GCKR.
34	8662230	F-1-P is the end product of ketohexokinase (KHK, fructokinase), which, like GCK and GCKR, is present in both liver and pancreatic islet.
35	8662230	We have isolated genomic clones containing the human GCKR and KHK genes.
36	8662230	By fluorescent in situ hybridization (FISH), KHK maps to Chromosome (Chr) 2p23.2-23.3, a new assignment corroborated by somatic cell hybrid analysis.
37	8662230	The localization of GCKR, originally reported by others as 2p22.3, has been reassessed by high-resolution FISH, indicating that, like KHK, GCKR maps to 2p23.2-23.3.
38	8662230	The proximity of GCKR and KHK was further demonstrated both by two-color interphase FISH, which suggests that the two genes lie within 500 kb of each other, and by analysis of overlapping YAC and P1 clones spanning the interval between GCKR and KHK.
39	8662230	It also raises the possibility of coordinate regulation of GCKR and KHK by common cis-acting regulatory elements.
40	8662230	Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23.
41	8662230	The role of glucokinase (GCK) as pancreatic beta cell glucose sensor and the finding of GCK mutations in maturity onset diabetes of the young (MODY) suggest GCKR as a further candidate gene for type 2 diabetes.
42	8662230	The inhibition of GCK by GCKR is relieved by the binding of fructose-1-phosphate (F-1-P) to GCKR.
43	8662230	F-1-P is the end product of ketohexokinase (KHK, fructokinase), which, like GCK and GCKR, is present in both liver and pancreatic islet.
44	8662230	We have isolated genomic clones containing the human GCKR and KHK genes.
45	8662230	By fluorescent in situ hybridization (FISH), KHK maps to Chromosome (Chr) 2p23.2-23.3, a new assignment corroborated by somatic cell hybrid analysis.
46	8662230	The localization of GCKR, originally reported by others as 2p22.3, has been reassessed by high-resolution FISH, indicating that, like KHK, GCKR maps to 2p23.2-23.3.
47	8662230	The proximity of GCKR and KHK was further demonstrated both by two-color interphase FISH, which suggests that the two genes lie within 500 kb of each other, and by analysis of overlapping YAC and P1 clones spanning the interval between GCKR and KHK.
48	8662230	It also raises the possibility of coordinate regulation of GCKR and KHK by common cis-acting regulatory elements.
49	8662230	Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23.
50	8662230	The role of glucokinase (GCK) as pancreatic beta cell glucose sensor and the finding of GCK mutations in maturity onset diabetes of the young (MODY) suggest GCKR as a further candidate gene for type 2 diabetes.
51	8662230	The inhibition of GCK by GCKR is relieved by the binding of fructose-1-phosphate (F-1-P) to GCKR.
52	8662230	F-1-P is the end product of ketohexokinase (KHK, fructokinase), which, like GCK and GCKR, is present in both liver and pancreatic islet.
53	8662230	We have isolated genomic clones containing the human GCKR and KHK genes.
54	8662230	By fluorescent in situ hybridization (FISH), KHK maps to Chromosome (Chr) 2p23.2-23.3, a new assignment corroborated by somatic cell hybrid analysis.
55	8662230	The localization of GCKR, originally reported by others as 2p22.3, has been reassessed by high-resolution FISH, indicating that, like KHK, GCKR maps to 2p23.2-23.3.
56	8662230	The proximity of GCKR and KHK was further demonstrated both by two-color interphase FISH, which suggests that the two genes lie within 500 kb of each other, and by analysis of overlapping YAC and P1 clones spanning the interval between GCKR and KHK.
57	8662230	It also raises the possibility of coordinate regulation of GCKR and KHK by common cis-acting regulatory elements.
58	8662230	Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23.
59	8662230	The role of glucokinase (GCK) as pancreatic beta cell glucose sensor and the finding of GCK mutations in maturity onset diabetes of the young (MODY) suggest GCKR as a further candidate gene for type 2 diabetes.
60	8662230	The inhibition of GCK by GCKR is relieved by the binding of fructose-1-phosphate (F-1-P) to GCKR.
61	8662230	F-1-P is the end product of ketohexokinase (KHK, fructokinase), which, like GCK and GCKR, is present in both liver and pancreatic islet.
62	8662230	We have isolated genomic clones containing the human GCKR and KHK genes.
63	8662230	By fluorescent in situ hybridization (FISH), KHK maps to Chromosome (Chr) 2p23.2-23.3, a new assignment corroborated by somatic cell hybrid analysis.
64	8662230	The localization of GCKR, originally reported by others as 2p22.3, has been reassessed by high-resolution FISH, indicating that, like KHK, GCKR maps to 2p23.2-23.3.
65	8662230	The proximity of GCKR and KHK was further demonstrated both by two-color interphase FISH, which suggests that the two genes lie within 500 kb of each other, and by analysis of overlapping YAC and P1 clones spanning the interval between GCKR and KHK.
66	8662230	It also raises the possibility of coordinate regulation of GCKR and KHK by common cis-acting regulatory elements.
67	19158351	Once in the cell, fructose is phosphorylated by ketohexokinase (KHK), leading to consumption of ATP, formation of AMP, and generation of uric acid through xanthine oxidoreductase (XOR).
68	19158351	Several antioxidants, including specific inhibitors of NADPH oxidase and XOR, prevented MCP-1 secretion.
69	23112875	The mechanism whereby uric acid stimulates KHK expression involves the activation of the transcription factor ChREBP, which, in turn, results in the transcriptional activation of KHK by binding to a specific sequence within its promoter.