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PMID |
Sentence |
1 |
2838353
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For the in vitro investigation, we evaluated whether insulin affects platelet function at a physiological hormone concentration by incubating the platelet-rich plasma (PRP) of fasting subjects with human regular insulin at the final concentration of 40 microU/ml for 30 min; we observed a significant reduction of platelet sensitivity to all the aggregating agents employed, i.e., ADP, platelet-activating factor (PAF), epinephrine, collagen, and Na+ arachidonate.
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2 |
2838353
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Our study rules out the possibility that insulin reduces platelet-function-modifying intraplatelet cAMP levels or thromboxane A2 production, because this hormone decreases the platelet concentrations of cAMP--a phenomenon that, per se, promotes platelet aggregation--and does not modify collagen or Na+ arachidonate--induced platelet production of thromboxane A2, measured by radioimmunoassay of its stable-metabolite thromboxane B2.
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3 |
7553983
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Scoparone (1) and scopoletin (2) exhibit a potent inhibitory effect on rabbit platelet aggregation induced by four types of agent, ADP, PAF, sodium arachidonate and/or collagen.
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4 |
8077800
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Treadmill-test; ADP-, PAF-, 5-HT-induced platelet aggregation; D-dimer; PAI-1 activity; blood viscosity at high and low shear rate; hematocrit were performed.
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5 |
9862387
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Differing haemodynamic and catecholamine responses to exercise in three groups with peripheralautonomic dysfunction: insulin-dependent diabetes mellitus, familial amyloid polyneuropathy and pure autonomic failure.
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6 |
9862387
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The haemodynamic and catecholamine responses to supine exercise, and the effect on standing blood pressure (BP), were studied in three groups with peripheral autonomic dysfunction; insulin-dependent diabetes mellitus (IDDM), familial amyloid polyneuropathy (FAP) and pure autonomic failure (PAF).
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7 |
9862387
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With exercise, BP increased in controls, was unchanged in IDDM and FAP, and fell in PAF.
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8 |
9862387
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Heart rate (HR) increased more in controls than IDDM, FAP or PAF.
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9 |
9862387
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Cardiac index (CI) increased less in IDDM than controls, FAP or PAF.
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10 |
9862387
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Systemic vascular resistance (SVR) fell similarly in controls and IDDM, with a greater fall in FAP and PAF.
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11 |
9862387
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On standing, BP was unchanged in controls; BP fell pre- and post-exercise in IDDM, FAP and PAF, with a significantly greater fall post-exercise in FAP and PAF.
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12 |
9862387
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Differing haemodynamic and catecholamine responses to exercise in three groups with peripheralautonomic dysfunction: insulin-dependent diabetes mellitus, familial amyloid polyneuropathy and pure autonomic failure.
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13 |
9862387
|
The haemodynamic and catecholamine responses to supine exercise, and the effect on standing blood pressure (BP), were studied in three groups with peripheral autonomic dysfunction; insulin-dependent diabetes mellitus (IDDM), familial amyloid polyneuropathy (FAP) and pure autonomic failure (PAF).
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14 |
9862387
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With exercise, BP increased in controls, was unchanged in IDDM and FAP, and fell in PAF.
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15 |
9862387
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Heart rate (HR) increased more in controls than IDDM, FAP or PAF.
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16 |
9862387
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Cardiac index (CI) increased less in IDDM than controls, FAP or PAF.
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17 |
9862387
|
Systemic vascular resistance (SVR) fell similarly in controls and IDDM, with a greater fall in FAP and PAF.
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18 |
9862387
|
On standing, BP was unchanged in controls; BP fell pre- and post-exercise in IDDM, FAP and PAF, with a significantly greater fall post-exercise in FAP and PAF.
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19 |
9862387
|
Differing haemodynamic and catecholamine responses to exercise in three groups with peripheralautonomic dysfunction: insulin-dependent diabetes mellitus, familial amyloid polyneuropathy and pure autonomic failure.
|
20 |
9862387
|
The haemodynamic and catecholamine responses to supine exercise, and the effect on standing blood pressure (BP), were studied in three groups with peripheral autonomic dysfunction; insulin-dependent diabetes mellitus (IDDM), familial amyloid polyneuropathy (FAP) and pure autonomic failure (PAF).
|
21 |
9862387
|
With exercise, BP increased in controls, was unchanged in IDDM and FAP, and fell in PAF.
|
22 |
9862387
|
Heart rate (HR) increased more in controls than IDDM, FAP or PAF.
|
23 |
9862387
|
Cardiac index (CI) increased less in IDDM than controls, FAP or PAF.
|
24 |
9862387
|
Systemic vascular resistance (SVR) fell similarly in controls and IDDM, with a greater fall in FAP and PAF.
|
25 |
9862387
|
On standing, BP was unchanged in controls; BP fell pre- and post-exercise in IDDM, FAP and PAF, with a significantly greater fall post-exercise in FAP and PAF.
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26 |
9862387
|
Differing haemodynamic and catecholamine responses to exercise in three groups with peripheralautonomic dysfunction: insulin-dependent diabetes mellitus, familial amyloid polyneuropathy and pure autonomic failure.
|
27 |
9862387
|
The haemodynamic and catecholamine responses to supine exercise, and the effect on standing blood pressure (BP), were studied in three groups with peripheral autonomic dysfunction; insulin-dependent diabetes mellitus (IDDM), familial amyloid polyneuropathy (FAP) and pure autonomic failure (PAF).
|
28 |
9862387
|
With exercise, BP increased in controls, was unchanged in IDDM and FAP, and fell in PAF.
|
29 |
9862387
|
Heart rate (HR) increased more in controls than IDDM, FAP or PAF.
|
30 |
9862387
|
Cardiac index (CI) increased less in IDDM than controls, FAP or PAF.
|
31 |
9862387
|
Systemic vascular resistance (SVR) fell similarly in controls and IDDM, with a greater fall in FAP and PAF.
|
32 |
9862387
|
On standing, BP was unchanged in controls; BP fell pre- and post-exercise in IDDM, FAP and PAF, with a significantly greater fall post-exercise in FAP and PAF.
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33 |
11527989
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The in vitro responsiveness of PMNs stimulated with fMLP or PAF was inversely correlated with indices of in vivo glycemic control (fasting plasma glucose and glycated-hemoglobin levels).
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34 |
15351860
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Our results showed that in Ca 2(+)-containing media, there was no significant differences in the basal [Ca(2+)](i), but the maximal increases of [Ca(2+)](i) of platelets were higher (p <0.05) in group 1 than in group 2 after stimulating with PAF and ADP, but not with thrombin and arachidonic acid.
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35 |
15958323
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[Relationship between serum vWF and PAF in type 2 diabetic patients and diabetic nephropathy].
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36 |
17557140
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We compared statistically the associations of CRP and LDL-C levels with risk of MI versus stroke and examined to what extent consideration of CRP or LDL-C increases the population attributable fractions (PAFs) of MI and stroke beyond traditional risk factors among 27,548 subjects from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study in a case-cohort design.
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37 |
17557140
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With additional consideration of CRP the PAFs were 0.80 and 0.68, while with addition of LDL-C the PAFs were 0.88 and 0.55.
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38 |
19773578
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A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.
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39 |
19773578
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LPCAT1 is a newly reported lysophospholipid acyltransferase implicated in the anti-inflammatory response by its role in conversion of LPC to PC.
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40 |
21043754
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On the other hand Trovati et al(4) found reduced platelet aggregation responses to ADP, PAF, epinephrine, collagen and arachidonate in the presence of 40 µU/ml insulin.
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