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Gene Information

Gene symbol: KIF2A

Gene name: kinesin heavy chain member 2A

HGNC ID: 6318

Synonyms: HK2

Related Genes

#	Gene Symbol	Number of hits
1	INS	1 hits
2	TGFB1	1 hits
3	TXNIP	1 hits

Related Sentences

#	PMID	Sentence
1	11696451	Translational regulation of renal proximal tubular epithelial cell transforming growth factor-beta1 generation by insulin.
2	11696451	The aim of the current study was to examine the effect of insulin on the generation of TGF-beta1 by proximal tubular cells.
3	11696451	HK-2 cells were grown to confluence in the absence of insulin, and serum deprived for 48 hours before all experimental manipulations.
4	11696451	Addition of insulin (5 microg/ml) to the culture medium led to a time-dependent increase in TGF-beta1 concentration in the cell culture supernatant, and increased incorporation of radiolabeled amino acids into TGF-beta1 suggestive of de novo TGF-beta1 protein synthesis.
5	11696451	Addition of insulin did not alter TGF-beta1 mRNA expression as assessed by reverse transcriptase-polymerase chain reaction or Northern analysis.
6	11696451	Insulin-induced increase in TGF-beta1 concentration was not abrogated by actinomycin D, however, stimulation by insulin, in the presence of cycloheximide led to a dose-dependent decrease in TGF-beta1 production.
7	11696451	Addition of insulin had no effect on TGF-beta1 mRNA stability as assessed by actinomycin D chase, but led to increased binding of a cytoplasmic protein to a putative stem loop structure in the 5'-UTR of TGF-beta1 mRNA, previously implicated in the posttranscriptional control of TGF-beta1 synthesis.
8	11696451	To address the functional significance of insulin-induced alteration in TGF-beta1 synthesis, we examined its effect on matrix turnover.
9	11696451	Insulin stimulated type IV collagen gene expression and an increase in the concentrations of the type IV collagen laid down in the extracellular matrix.
10	11696451	This increase in type IV collagen was abrogated when cells were stimulated by insulin in the presence of an anti-TGF-beta1-blocking antibody.
11	11696451	In conclusion the data demonstrate that insulin may directly alter the production of TGF-beta1 by renal proximal tubular cells by a posttranscriptional mechanism, and that this may have implications for the increase in extracellular matrix that accompanies diabetic nephropathy.
12	17675577	High glucose-induced thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-beta1.
13	17675577	Txnip, heat shock proteins 70 and 90, chemokine (C-C motif) ligand 20, and matrix metalloproteinase-7 were chosen for verification of gene expression.
14	17675577	The increased protein expression of Txnip, CCL20, and MMP7 were also verified by Western blotting and enzyme-linked immunosorbent assay.
15	17675577	Subsequent studies focused on the dependence of Txnip expression on up-regulation of transforming growth factor (TGF)-beta1 under high-glucose conditions.
16	17675577	Overexpression of Txnip and up-regulation of Txnip promoter activity were observed in cells in which the TGF-beta1 gene was silenced in HK-2 cells using short interfering RNA technology.
17	17675577	High glucose further increased both Txnip expression and its promoter activity in TGF-beta1 silenced cells compared with wild-type cells exposed to high glucose, suggesting that high glucose induced Txnip through a TGF-beta1-indepen-dent pathway.