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Gene Information
Gene symbol: LASS4
Gene name: LAG1 homolog, ceramide synthase 4
HGNC ID: 23747
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AGPAT1 | 1 hits |
| 2 | APOA1 | 1 hits |
| 3 | APOE | 1 hits |
| 4 | ATP10D | 1 hits |
| 5 | DLG2 | 1 hits |
| 6 | ELOVL2 | 1 hits |
| 7 | KCNH7 | 1 hits |
| 8 | LIPC | 1 hits |
| 9 | PCDH20 | 1 hits |
| 10 | PDXDC1 | 1 hits |
| 11 | PLD2 | 1 hits |
| 12 | PNLIPRP2 | 1 hits |
| 13 | SGPP1 | 1 hits |
| 14 | SPTLC3 | 1 hits |
| 15 | SYT9 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19798445 | The strongest associations were observed in or near 7 genes functionally involved in ceramide biosynthesis and trafficking: SPTLC3, LASS4, SGPP1, ATP10D, and FADS1-3. |
| 2 | 19798445 | Variants in 3 loci (ATP10D, FADS3, and SPTLC3) associate with MI in a series of three German MI studies. |
| 3 | 22359512 | After a correction for multiple comparisons (P-value<2.2×10(-9)), we observed four novel loci significantly associated with phospholipids (PAQR9, AGPAT1, PKD2L1, PDXDC1) and two with sphingolipids (PLD2 and APOE) explaining up to 3.1% of the variance. |
| 4 | 22359512 | Further analysis of the top findings with respect to within class molar proportions uncovered three additional loci for phospholipids (PNLIPRP2, PCDH20, and ABDH3) suggesting their involvement in either fatty acid elongation/saturation processes or fatty acid specific turnover mechanisms. |
| 5 | 22359512 | Among those, 14 loci (KCNH7, AGPAT1, PNLIPRP2, SYT9, FADS1-2-3, DLG2, APOA1, ELOVL2, CDK17, LIPC, PDXDC1, PLD2, LASS4, and APOE) mapped into the glycerophospholipid and 12 loci (ILKAP, ITGA9, AGPAT1, FADS1-2-3, APOA1, PCDH20, LIPC, PDXDC1, SGPP1, APOE, LASS4, and PLD2) to the sphingolipid pathways. |