Ignet

Gene Information

Gene symbol: LPIN2

Gene name: lipin 2

HGNC ID: 14450

Synonyms: KIAA0249

Related Genes

#	Gene Symbol	Number of hits
1	CCL2	1 hits
2	IL6	1 hits
3	JUN	1 hits
4	LPIN1	1 hits
5	LPIN3	1 hits
6	MAPK8	1 hits
7	PDAP1	1 hits
8	RP9	1 hits

Related Sentences

#	PMID	Sentence
1	18245816	Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically.
2	18245816	Glucocorticoids (GCs) increase hepatic phosphatidate phosphatase (PAP1) activity.
3	18245816	PAP1 catalyzes the conversion of phosphatidate to diacylglycerol, a key substrate for TAG and phospholipid biosynthesis.
4	18245816	PAP1 enzymes in liver include lipin-1A and -1B (alternatively spliced isoforms) and two distinct gene products, lipin-2 and lipin-3.
5	18245816	We determined the mechanisms by which the composite PAP1 activity is regulated using rat and mouse hepatocytes.
6	18245816	Levels of lipin-1A and -1B mRNA were increased by dexamethasone (dex; a synthetic GC), and this resulted in increased lipin-1 synthesis, protein levels, and PAP1 activity.
7	18245816	Lipin-2 and lipin-3 mRNA were not increased by dex/cAMP, indicating that increased PAP1 activity is attributable specifically to enhanced lipin-1 expression.
8	18245816	Selective lipin-1 expression explains the GC and cAMP effects on increased hepatic PAP1 activity, which occurs in hepatic steatosis during starvation, diabetes, stress, and ethanol consumption.
9	18245816	Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically.
10	18245816	Glucocorticoids (GCs) increase hepatic phosphatidate phosphatase (PAP1) activity.
11	18245816	PAP1 catalyzes the conversion of phosphatidate to diacylglycerol, a key substrate for TAG and phospholipid biosynthesis.
12	18245816	PAP1 enzymes in liver include lipin-1A and -1B (alternatively spliced isoforms) and two distinct gene products, lipin-2 and lipin-3.
13	18245816	We determined the mechanisms by which the composite PAP1 activity is regulated using rat and mouse hepatocytes.
14	18245816	Levels of lipin-1A and -1B mRNA were increased by dexamethasone (dex; a synthetic GC), and this resulted in increased lipin-1 synthesis, protein levels, and PAP1 activity.
15	18245816	Lipin-2 and lipin-3 mRNA were not increased by dex/cAMP, indicating that increased PAP1 activity is attributable specifically to enhanced lipin-1 expression.
16	18245816	Selective lipin-1 expression explains the GC and cAMP effects on increased hepatic PAP1 activity, which occurs in hepatic steatosis during starvation, diabetes, stress, and ethanol consumption.
17	20692363	Growing evidence links the three mammalian lipin proteins, i.e., lipin-1, lipin-2 and lipin-3, to metabolic and cardiovascular diseases such as noninsulin-dependent diabetes mellitus and atherosclerosis.
18	20692363	Genetic variants within the human LPIN1 and LPIN2 genes are associated with metabolic syndromes.
19	20692363	The fatty liver dystrophy (fld) mice carrying mutations within the Lpin1 gene display life-long deficiency in adipogenesis, insulin resistance, neonatal hepatosteatosis and hypertriglyceridemia, as well as increased atherosclerosis susceptibility.
20	20692363	Cell culture studies show that hepatic lipin-1 expression is selectively stimulated by glucocorticoids and repressed by insulin, and its subcellular localization governs the assembly and secretion of very low density lipoproteins (VLDL).
21	20692363	Growing evidence links the three mammalian lipin proteins, i.e., lipin-1, lipin-2 and lipin-3, to metabolic and cardiovascular diseases such as noninsulin-dependent diabetes mellitus and atherosclerosis.
22	20692363	Genetic variants within the human LPIN1 and LPIN2 genes are associated with metabolic syndromes.
23	20692363	The fatty liver dystrophy (fld) mice carrying mutations within the Lpin1 gene display life-long deficiency in adipogenesis, insulin resistance, neonatal hepatosteatosis and hypertriglyceridemia, as well as increased atherosclerosis susceptibility.
24	20692363	Cell culture studies show that hepatic lipin-1 expression is selectively stimulated by glucocorticoids and repressed by insulin, and its subcellular localization governs the assembly and secretion of very low density lipoproteins (VLDL).
25	20943485	Lipin family including at least three members Lipin 1, Lipin 2, and Lipin 3 is a critical regulatory enzyme identified recently, which plays dual roles in lipid metabolisms.
26	22334674	Depletion of lipin-2 promotes the increased expression of the proinflammatory genes Il6, Ccl2, and Tnfα, which depends on the overstimulation of the JNK1/c-Jun pathway by saturated fatty acids.