Ignet

Gene Information

Gene symbol: LYPLAL1

Gene name: lysophospholipase-like 1

HGNC ID: 20440

Synonyms: Q96AV0

Related Genes

#	Gene Symbol	Number of hits
1	ADAMTS9	1 hits
2	BDNF	1 hits
3	COBLL1	1 hits
4	ETV5	1 hits
5	FADS1	1 hits
6	FTO	1 hits
7	GCKR	1 hits
8	GNPDA2	1 hits
9	GRB14	1 hits
10	HSD17B4	1 hits
11	KCTD15	1 hits
12	MAF	1 hits
13	MAP3K1	1 hits
14	MC4R	1 hits
15	MSRA	1 hits
16	MTCH2	1 hits
17	MTMR9	1 hits
18	NEGR1	1 hits
19	NRXN3	1 hits
20	SCG3	1 hits
21	SEC16B	1 hits
22	SH2B1	1 hits
23	SLC30A10	1 hits
24	TFAP2B	1 hits
25	TMEM18	1 hits
26	VEGFA	1 hits

Related Sentences

#	PMID	Sentence
1	21674055	Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes.
2	21686128	Three loci were recently identified for central adiposity from a genome wide association study (MSRA [rs545854; G/C], LYPLAL1 [rs2605100; G/A], TFAP2B [rs987237; A/G]).
3	21686128	Carriers of the TFAP2B risk variant, however, had lower leptin levels (-2.7 ng/ml, p=0.005).
4	21796137	Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population.
5	21796137	There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1.
6	21796137	Four SNPs in the FTO gene were significantly related to metabolic syndrome: rs9939609 (P=0.00013), rs8050136 (P=0.00011), rs1558902 (P=6.6 × 10(-5)) and rs1421085 (P=7.4 × 10(-5)). rs3764220 in the SCG3 gene (P=0.0010) and rs2293855 in the MTMR9 gene (P=0.0015) were also significantly associated with metabolic syndrome.
7	21796137	SNPs in the FTO, SCG3 and MTMR9 genes had no SNP × SNP epistatic effects on metabolic syndrome.
8	21796137	Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome.
9	23754948	Seven loci displayed significant sex-difference (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were genome-wide significant in women (P<5×10(-8)), but not in men.