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Gene Information
Gene symbol: MBD3
Gene name: methyl-CpG binding domain protein 3
HGNC ID: 6918
Related Genes
Related Sentences
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PMID |
Sentence |
1 |
20738330
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Silver-Russell patients showing a broad range of ICR1 and ICR2 hypomethylation in different tissues.
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2 |
20738330
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However, several patients with transient neonatal diabetes mellitus (TNDM), Silver-Russell syndrome (SRS) and Beckwith-Wiedemann syndrome (BWS) exhibiting multilocus hypomethylation (MLH) have meanwhile been described.
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3 |
20738330
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Whereas TNDM patients with MLH show clinical symptoms different from carriers with isolated 6q24 aberrations, MLH carriers diagnosed as BWS or SRS present only the syndrome-specific features.
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4 |
20738330
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Interestingly, SRS and BWS patients with nearly identical MLH patterns in leukocytes have been identified.
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5 |
20738330
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Despite mutation screening of several factors involved in establishment and maintenance of methylation marks including ZFP57, MBD3, DNMT1 and DNMT3L the molecular clue for the ICR1/ICR2 hypomethylation in our patients remained unclear.
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