Ignet

Gene Information

Gene symbol: MDK

Gene name: midkine (neurite growth-promoting factor 2)

HGNC ID: 6972

Synonyms: MK, FLJ27379

Related Genes

#	Gene Symbol	Number of hits
1	AAVS1	1 hits
2	ACTB	1 hits
3	BRCA1	1 hits
4	CD44	1 hits
5	CDKN1C	1 hits
6	CSF1	1 hits
7	DDIT3	1 hits
8	DYNC1H1	1 hits
9	FOS	1 hits
10	GPR180	1 hits
11	HIST1H2BO	1 hits
12	HIST2H2BE	1 hits
13	HSPG2	1 hits
14	IGF1	1 hits
15	IGFALS	1 hits
16	IGFBP2	1 hits
17	IL2	1 hits
18	INS	1 hits
19	MAPK6	1 hits
20	MLLT3	1 hits
21	SERPINE1	1 hits
22	SLC9A3R2	1 hits
23	SMARCA1	1 hits
24	TP63	1 hits

Related Sentences

#	PMID	Sentence
1	9032395	The Rep proteins of adeno-associated virus type 2 (AAV) are known to bind to Rep recognition sequences (RRSs) in the AAV inverted terminal repeats (ITRs), the AAV p5 promoter, and the preferred AAV integration site in human chromosome 19, called AAVS1.
2	9032395	We used the 16-mer core sequences of the RRSs in the AAV ITRs and AAVS1 separately as query sequences and identified 18 new RRSs in or flanking the genes coding for the following: tyrosine kinase activator protein 1 (TKA-1); colony stimulating factor-1; insulin-like growth factor binding protein 2 (IGFBP-2); histone H2B.1; basement membrane heparan sulfate proteoglycan, also known as perlecan; the AF-9 gene product, which is involved in the chromosomal translocation t (9:11)(p22:q23); the betaB subunit of the hormone known as inhibin; interleukin-2 enhancer binding factor; an endoplasmic reticulum-Golgi intermediate compartment resident protein called p63; a global transcription activator (hSNF2L); the beta-actin repair domain; a retinoic acid-inducible factor, also known as midkine; a breast tumor autoantigen; a growth-arrest- and DNA-damage-inducible protein called gadd45; the cyclin-dependent kinase inhibitor called KIP2, which inhibits several G1 cyclin-cyclin-dependent kinase complexes; and the hereditary breast and ovarian cancer gene (BRCA1).
3	16400005	Mdk-/- mesangial cells exhibited reduced phosphorylation of protein kinase C and extracellular signal-regulated kinase as well as reduced production of transforming growth factor-beta(1) on high glucose loading.
4	16400005	Addition of exogenous midkine restored extracellular signal-regulated kinase phosphorylation in Mdk-/- cells under high glucose conditions, whereas a midkine antisense oligodeoxynucleotide suppressed midkine in Mdk+/+ cells.
5	23543126	Loss of heparin-binding protein prevents necrotizing glomerulonephritis: first clues hint at plasminogen activator inhibitor-1.
6	23543126	Here, we discuss a recent publication that provides evidence for the beneficial role of midkine in progressive glomerulonephritis, most likely due to blockade of plasminogen activator inhibitor-1 release.