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Gene Information
Gene symbol: MEF2D
Gene name: myocyte enhancer factor 2D
HGNC ID: 6997
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | MEF2A | 1 hits |
| 3 | MEF2C | 1 hits |
| 4 | SLC2A4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10748204 | The MEF2A isoform is required for striated muscle-specific expression of the insulin-responsive GLUT4 glucose transporter. |
| 2 | 10748204 | Previously, we have demonstrated that an MEF2 consensus sequence located between -473/-464 in the human GLUT4 gene was essential for both tissue-specific and hormonal/metabolic regulation of GLUT4 expression (Thai, M. |
| 3 | 10748204 | To identify the specific MEF2 isoform(s) responsible for GLUT4 expression, we studied the pattern of expression of the MEF2 isoforms in insulin-sensitive tissues. |
| 4 | 10748204 | Both heart and skeletal muscle were found to express the MEF2A, MEF2C, and MEF2D isoforms but not MEF2B. |
| 5 | 10748204 | However, only the MEF2A protein was selectively down-regulated in insulin-deficient diabetes. |
| 6 | 10748204 | Electrophoretic mobility shift assays revealed that nuclear extracts from diabetic animals had reduced binding to the MEF2 binding site compared with extracts from control or insulin-treated animals. |
| 7 | 10748204 | However, addition of MEF2A to diabetic nuclear extracts fully restored binding activity to the MEF2 element. |
| 8 | 10748204 | These data strongly suggest that the MEF2A-MEF2D heterodimer is selectively decreased in insulin-deficient diabetes and is responsible for hormonally regulated expression of the GLUT4 gene. |
| 9 | 11316766 | The MEF2A and MEF2D isoforms are differentially regulated in muscle and adipose tissue during states of insulin deficiency. |
| 10 | 11316766 | Previously we have demonstrated that striated muscle GLUT4 gene expression decreased following streptozotocin-induced diabetes due to a loss of MEF2A transcription factor expression without any significant effect on the MEF2D isoform (Mora, S. and J. |
| 11 | 11316766 | However, addition of in vitro synthesized MEF2A to adipose nuclear extracts results in the formation of the expected MEF2/DNA complex. |
| 12 | 11316766 | Furthermore, in vivo overexpression of MEF2A selectively in adipose tissue did not affect GLUT4 or MEF2D expression and was not sufficient to prevent GLUT4 down-regulation that occurred in insulin-deficient states. |
| 13 | 11316766 | The MEF2A and MEF2D isoforms are differentially regulated in muscle and adipose tissue during states of insulin deficiency. |
| 14 | 11316766 | Previously we have demonstrated that striated muscle GLUT4 gene expression decreased following streptozotocin-induced diabetes due to a loss of MEF2A transcription factor expression without any significant effect on the MEF2D isoform (Mora, S. and J. |
| 15 | 11316766 | However, addition of in vitro synthesized MEF2A to adipose nuclear extracts results in the formation of the expected MEF2/DNA complex. |
| 16 | 11316766 | Furthermore, in vivo overexpression of MEF2A selectively in adipose tissue did not affect GLUT4 or MEF2D expression and was not sufficient to prevent GLUT4 down-regulation that occurred in insulin-deficient states. |