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Gene Information
Gene symbol: MIRN212
Gene name: microRNA 212
HGNC ID: 31589
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | INSR | 1 hits |
| 3 | RORC | 1 hits |
| 4 | RPS6KB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21977024 | In conditions of over-nutrition, increased insulin (INS) and angiotensin II (Ang II) activate mammalian target for rapamycin (mTOR)/p70 S6 kinase (S6K1) signaling, whereas chronic alcohol consumption inhibits mTOR/S6K1 activation in cardiac tissue. |
| 2 | 21977024 | Although excessive activation of mTOR/S6K1 induces cardiac INS resistance via serine phosphorylation of INS receptor substrates (IRS-1/2), it also renders cardioprotection via increased Ang II receptor 2 (AT2R) upregulation and adaptive hypertrophy. |
| 3 | 21977024 | Conversely, alcohol-mediated inhibition of mTOR/S6K1, down-regulation of INS receptor and growth-inhibitory mir-200 family, and upregulation of mir-212 that promotes fetal gene program may exacerbate CRS-related cardiomyopathy. |