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Gene Information

Gene symbol: MIRN453

Gene name:

HGNC ID:

Related Genes

#	Gene Symbol	Number of hits
1	ACAA1	1 hits
2	IGF2R	1 hits
3	MIRN657	1 hits

Related Sentences

#	PMID	Sentence
1	18602895	Allele-specific targeting of hsa-miR-657 to human IGF2R creates a potential mechanism underlying the association of ACAA-insertion/deletion polymorphism with type 2 diabetes.
2	18602895	In this study, a prediction by web tools MicroInspector and miRanda demonstrated that DNA sequence polymorphism (DSPs) ACAA-insertion/deletion in IGF2R 3'UTR is located within the hsa-miR-657 and hsa-miR-453 binding sites.
3	18602895	And luciferase reporter assay revealed that hsa-miR-657 acts directly at the 3'UTR of the IGF2R.
4	18602895	Furthermore, ACAA-deletion exerted a further repression compared with ACAA-insertion, indicating that hsa-miR-657 regulates IGF2R gene expression in a polymorphic control manner.
5	18602895	Importantly, we also demonstrated that hsa-miR-657 can translationally regulate the IGF2R expression levels in Hep G2 cells.
6	18602895	Thus, our findings testify the possibility that the ACAA-insertion/deletion polymorphism may result in the change of IGF2R expression levels at least in part by hsa-miR-657-mediated regulation, contributing to the elucidation for the pathogenesis of type 2 diabetes and raise the possibility that miRNAs or in combination with functional DNA sequence polymorphism may be valuable in the treatment of human type 2 diabetes.