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PMID |
Sentence |
1 |
14530283
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Expression profiling identifies genes that continue to respond to insulin in adipocytes made insulin-resistant by treatment with tumor necrosis factor-alpha.
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2 |
14530283
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We have employed microarray technology using RNA from normal 3T3-L1 adipocytes and from 3T3-L1 adipocytes made insulin-resistant by treatment with tumor necrosis factor-alpha to identify a new class of insulin-responsive genes.
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3 |
14530283
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Socs-3, junB, and matrix metalloproteinase-11).
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4 |
14530283
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Glut-1 and beta3-adrenergic receptor), other novel insulin-sensitive genes were also identified (e.g.
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5 |
14530283
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Egr-1, epiregulin, Fra-1, and ABCA1).
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6 |
14530283
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Using an antisense strategy, we show that tissue factor and macrophage colony-stimulating factor, two cardiovascular risk factors, are downstream EGR-1 target genes in the adipocyte.
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7 |
22858798
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NZ10 mice on CD showed increased body weight, hyperglycemia, and hyperinsulinemia at 25 weeks whereas those on HPO diet retained normal insulin levels and were normoglycemic.
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8 |
22858798
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Real time-PCR (RT-PCR) confirmed markedly increased expression of matrix metalloproteinases (MMPs) 2, 3, 11, and 12, vascular endothelial growth factor-A and C (VEGF-A and C), Von Willebrand Factor, and peroxisome proliferator-activated receptor-γ (PPAR-γ) selectively in the NZ10/CD group.
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9 |
22858798
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Protein levels of MMP2, 3, and 9 were significantly increased in the VA of NZ10 mice fed CD while those of MMP7 were downregulated.
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