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Gene Information
Gene symbol: MMP12
Gene name: matrix metallopeptidase 12 (macrophage elastase)
HGNC ID: 7158
Synonyms: HME
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCL2 | 1 hits |
| 2 | FOS | 1 hits |
| 3 | IL1B | 1 hits |
| 4 | INS | 1 hits |
| 5 | MMP11 | 1 hits |
| 6 | MMP2 | 1 hits |
| 7 | MMP3 | 1 hits |
| 8 | NOS2A | 1 hits |
| 9 | VEGFA | 1 hits |
| 10 | VWF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10807873 | A higher binding affinity of AP-1 to the A allele was associated with higher MMP-12 promoter activity in vitro in transient transfection studies in U937 and murine lung macrophage (MALU) cells. |
| 2 | 10807873 | Phorbol 12-myristate 13-acetate (PMA) and insulin, 2 known activators of AP-1, increased the binding of AP-1 to the MMP-12 promoter, with higher affinity for the A allele. |
| 3 | 10807873 | Furthermore, Western blot analysis demonstrated that insulin increased MMP-12 protein production. |
| 4 | 10807873 | A higher binding affinity of AP-1 to the A allele was associated with higher MMP-12 promoter activity in vitro in transient transfection studies in U937 and murine lung macrophage (MALU) cells. |
| 5 | 10807873 | Phorbol 12-myristate 13-acetate (PMA) and insulin, 2 known activators of AP-1, increased the binding of AP-1 to the MMP-12 promoter, with higher affinity for the A allele. |
| 6 | 10807873 | Furthermore, Western blot analysis demonstrated that insulin increased MMP-12 protein production. |
| 7 | 10807873 | A higher binding affinity of AP-1 to the A allele was associated with higher MMP-12 promoter activity in vitro in transient transfection studies in U937 and murine lung macrophage (MALU) cells. |
| 8 | 10807873 | Phorbol 12-myristate 13-acetate (PMA) and insulin, 2 known activators of AP-1, increased the binding of AP-1 to the MMP-12 promoter, with higher affinity for the A allele. |
| 9 | 10807873 | Furthermore, Western blot analysis demonstrated that insulin increased MMP-12 protein production. |
| 10 | 21030598 | IL-1β, inducible nitric-oxide synthase, and TNF-α), monocyte chemoattractant protein-1, and matrix metalloproteinase-12 in microglia. |
| 11 | 21277817 | We identified associations at several correlated SNPs across a 29.2kb interval on chromosome 11q at the MMP-3/MMP-12 locus. |
| 12 | 21277817 | Taken together, our study suggests that genetic variations within the MMP-3/MMP-12 locus influence susceptibility of DN in type 1 diabetes. |
| 13 | 21277817 | We identified associations at several correlated SNPs across a 29.2kb interval on chromosome 11q at the MMP-3/MMP-12 locus. |
| 14 | 21277817 | Taken together, our study suggests that genetic variations within the MMP-3/MMP-12 locus influence susceptibility of DN in type 1 diabetes. |
| 15 | 22858798 | NZ10 mice on CD showed increased body weight, hyperglycemia, and hyperinsulinemia at 25 weeks whereas those on HPO diet retained normal insulin levels and were normoglycemic. |
| 16 | 22858798 | Real time-PCR (RT-PCR) confirmed markedly increased expression of matrix metalloproteinases (MMPs) 2, 3, 11, and 12, vascular endothelial growth factor-A and C (VEGF-A and C), Von Willebrand Factor, and peroxisome proliferator-activated receptor-γ (PPAR-γ) selectively in the NZ10/CD group. |
| 17 | 22858798 | Protein levels of MMP2, 3, and 9 were significantly increased in the VA of NZ10 mice fed CD while those of MMP7 were downregulated. |