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Gene Information
Gene symbol: MSH2
Gene name: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
HGNC ID: 7325
Synonyms: HNPCC, HNPCC1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CDKN2A | 1 hits |
| 2 | FZR1 | 1 hits |
| 3 | MLH1 | 1 hits |
| 4 | MSH3 | 1 hits |
| 5 | PTEN | 1 hits |
| 6 | RASSF1 | 1 hits |
| 7 | TIMP3 | 1 hits |
| 8 | VHL | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15662588 | Inactivation of p16 and Pten was related to the development of pheochromocytomas. |
| 2 | 15662588 | In this report, we investigated the methylation status of the p16INK4a cell cycle inhibitor gene and other prominent tumor-related genes ( PTEN, RASSF1 A, CDH1, MSH2, MLH1, VHL, and TIMP3) in sporadic and multiple endocrine neoplasia type 2 (MEN2) pheochromocytomas by methylation-specific PCR. |
| 3 | 15662588 | Hypermethylation was detected in 48 % of pheochromocytomas for RASSF1 A, 24 % for p16, 36 % for MSH2, 16 % for CDH1, and 8 % for PTEN. |
| 4 | 15662588 | No VHL, MLH1, and TIMP3 methylation was observed. |
| 5 | 15662588 | Interestingly, the frequency of p16 inactivation in familial tumors was higher (5 out of 12, 42 %) than in sporadic tumors (1 out of 13, 8 %; p = 0.047) and RASSF1 A inactivation was more common in the hereditary tumors (58 %) compared to the sporadic tumors (38 %). |
| 6 | 15662588 | Combined methylation of RASSF1 A and p16 was found only in MEN2-related pheochromocytomas. |
| 7 | 15662588 | Thus, a subset of hereditary pheochromocytomas displays preferential methylation of p16 and RASSF1 A. |
| 8 | 22179786 | The C-terminal dimerization domains form an integral part of the MutS structure and coordinate asymmetrical ATP hydrolysis by Msh2 and Msh3 with mismatch binding to signal for repair. |