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Gene Information

Gene symbol: NCAM2

Gene name: neural cell adhesion molecule 2

HGNC ID: 7657

Synonyms: NCAM21, MGC51008

Related Genes

#	Gene Symbol	Number of hits
1	CA2	1 hits
2	CA3	1 hits
3	NCAM1	1 hits

Related Sentences

#	PMID	Sentence
1	16247769	Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1.
2	16247769	Different causes, such as maternal diabetes, cloning by nuclear transfer, interspecific hybridization, and deletion of some genes such as Esx1, Ipl, or Cdkn1c, may underlie placental overgrowth.
3	16247769	In the present study, we focused on two genes, Car2 and Ncam1, which both exhibited increased expression in interspecies and cloned hyperplastic placentas.
4	16247769	Apart from a detailed expression analysis of both genes during normal murine placentation, we also assessed morphology of placentas that were null for Car2 or Ncam1.
5	16247769	Finally, we attempted to rescue placental hyperplasia in a congenic model of IHPD by decreasing transcript levels of Car2 or Ncam1.
6	16247769	Contrary to expectations, homozygous deletion of either Car2 or Ncam1 did not result in placental phenotypes.
7	16247769	However, expression analysis of Car3 and Ncam2, which can take over the function of Car2 and Ncam1, respectively, indicated a possible rescue mechanism, as Car3 and Ncam2 were expressed in spongiotrophoblast of Car2 and Ncam1 mutant placentas.
8	16247769	On the other hand, downregulation of either Car2 or Ncam1 did not rescue any of the placental phenotypes of AT24 placentas, a congenic model for interspecies hybrid placentas.
9	16247769	This strongly suggested that altered expression of Car2 and Ncam1 is a downstream event in placental hyperplasia.