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Gene Information
Gene symbol: NDUFB8
Gene name: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
HGNC ID: 7703
Synonyms: ASHI, CI-ASHI
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CAPN10 | 1 hits |
| 2 | CASP3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22012129 | High glucose increased mitochondrial calpain 10 substrates (NDUFB8 and ATP synthase β), decreased basal and uncoupled respiration, and initiated cell apoptosis as indicated by cleaved caspase 3 and nuclear condensation. |
| 2 | 22012129 | In agreement with our in vitro data, the kidneys of streptozotocin-induced diabetic rats had elevated calpain 10 substrates and cleaved caspase 3. |
| 3 | 22012129 | Finally, specific siRNA-induced knockdown of calpain 10 in the proximal tubules of control rats resulted in decreased renal function as evidenced by increased serum creatinine, and increased caspase 3 cleavage compared with rats receiving scrambled siRNA. |
| 4 | 22612451 | Calpain 10 is a ubiquitously expressed mitochondrial and cytosolic Ca(2+)-regulated cysteine protease in which overexpression or knockdown leads to mitochondrial dysfunction and cell death. |
| 5 | 22612451 | Therefore, we created a homology model using the calpain 10 amino acid sequence and calpain 1 3-D structure and docked CYGAK in the active site. |
| 6 | 22612451 | RPTC treated with 10 μM CYGAK-OC for 24 h induced accumulation of ATP synthase β and NDUFB8, two calpain 10 substrates. |