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Gene Information
Gene symbol: NEDD4L
Gene name: neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
HGNC ID: 7728
Synonyms: KIAA0439, RSP5, NEDD4-2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CLDN4 | 1 hits |
| 2 | CTNNA2 | 1 hits |
| 3 | FOXO3 | 1 hits |
| 4 | GRB10 | 1 hits |
| 5 | JUP | 1 hits |
| 6 | LIPG | 1 hits |
| 7 | MAGI2 | 1 hits |
| 8 | NFKB1 | 1 hits |
| 9 | RNF123 | 1 hits |
| 10 | SERPINB7 | 1 hits |
| 11 | SGK1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19690890 | Two candidate genes stood out: NEDD4L and SERPINB7. |
| 2 | 20740360 | The RGZ-induced Iam increase was not mediated through direct serum- and glucocorticoid-regulated kinase (SGK1)-dependent phosphorylation of serine residue 594 on the human ENaC α-subunit but by the diminution of ENaC ubiquitination through the SGK1/Nedd4-2 pathway. |
| 3 | 23552671 | The associated genes included 3 previously reported to associate with T2D or related traits (GRB10, NEDD4L, LIPG) and 24 novel candidate genes, including genes in lipid metabolism (ACOXL) and cell-cell and cell-matrix adhesion (MAGI2, CLDN4, CTNNA2). |
| 4 | 23933686 | SGK1 is activated by insulin and growth factors via phosphatidylinositol-3-kinase, 3-phosphoinositide dependent-kinase PDK1, and mTOR. |
| 5 | 23933686 | NCC, NKCC, NHE1, NHE3, SGLT1, several amino acid transporters) and many ion channels (e.g. |
| 6 | 23933686 | ENaC, SCN5A, TRPV4-6, Orai1/STIM1, ROMK, KCNE1/KCNQ1, GluR6, CFTR). |
| 7 | 23933686 | SGK1 further up-regulates a number of enzymes (e.g. glycogen-synthase-kinase-3, ubiquitin-ligase Nedd4-2), and transcription factors (e.g. forkhead-transcription-factor FOXO3a, β-catenin, nuclear-factor-kappa-B NFκB). |