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Gene Information

Gene symbol: NFATC2

Gene name: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

HGNC ID: 7776

Synonyms: NF-ATP, NFATp, NFAT1

Related Genes

#	Gene Symbol	Number of hits
1	CD2	1 hits
2	CEBPB	1 hits
3	CTLA4	1 hits
4	FOS	1 hits
5	GATA3	1 hits
6	HSPD1	1 hits
7	IFNG	1 hits
8	IL10	1 hits
9	IL1B	1 hits
10	IL2	1 hits
11	KLRG1	1 hits
12	NFATC1	1 hits
13	NFKB1	1 hits
14	NOX4	1 hits
15	PDX1	1 hits
16	TBX21	1 hits
17	TH1L	1 hits
18	TNF	1 hits

Related Sentences

#	PMID	Sentence
1	8098881	Our studies demonstrate for the first time that CD3 antigen-derived signals and CD2 antigen-derived signals are synergistic in inducing the emergence of transcription factors that bind to the NF-AT1, AP-1, and NF-kB sites located in the promoter/enhancer region of the IL-2 gene.
2	12524538	Here we have generated mice deficient for signal transducer and activator of transcription 6 (STAT6) and CTLA-4 to determine the role of CTLA-4 in cytokine-driven T cell differentiation.
3	12524538	CTLA-4-deficient T cells bypass the need for STAT6 in the differentiation of T helper type 2 (T(H)2) cells.
4	12524538	T(H)2 differentiation of cells deficient for both STAT6 and CTLA-4 is accompanied by induction of GATA-3 and the migration of T(H)2 cells to peripheral tissues.
5	12524538	CTLA-4 deficiency also affects the balance of the nuclear factors NFATc1 and NFATc2, and enhances activation of NF-kappaB.
6	12524538	These results suggest that CTLA-4 has a critical role in T cell differentiation and that STAT6-dependent T(H)2 lineage commitment and stabilization can be bypassed by increasing the strength of signaling through the T cell receptor.
7	15749853	Heat shock protein 60 inhibits Th1-mediated hepatitis model via innate regulation of Th1/Th2 transcription factors and cytokines.
8	15749853	Yet, HSP60 can also down-regulate experimental immune arthritis and diabetes models by specific inhibition of Th1-like responses.
9	15749853	We now report that HSP60 in vitro differentially modulates the expression of Th1/Th2 transcription factors in human T cells: HSP60 down-regulates T-bet, NF-kappaB, and NFATp and up-regulates GATA-3, leading to decreased secretion of TNF-alpha and IFN-gamma and enhanced secretion of IL-10.
10	15749853	In BALB/c mice, HSP60 in vivo inhibited the clinical, histological, and serological manifestations of Con A-induced hepatitis associated with up-regulated T cell expression of suppressor of cytokine signaling 3 and GATA-3 and down-regulated T-bet expression.
11	20033851	We found that Dickkopf 1 (Dkk1), a Wnt inhibitor, is overexpressed in skin fibroblast cells derived from three leprechaunism patients and that the cells showed an impaired response to Wnt2 in terms of beta-catenin-Tcf activation.
12	20033851	Concerted action of Wnt2 and knockdown of Dkk1 resulted in enhanced Nox4 expression and PDGF-induced ROS generation compared to parental patient cells.
13	20033851	Furthermore, we found that NFATc2 was activated in response to Wnt2 stimulation and directly activates Nox4 expression.
14	20424162	Regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) expression by interleukin-1 beta in pancreatic beta cells.
15	20424162	Here, we show that nuclear factor kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling pathways regulate the expression of CCAAT/enhancer-binding protein homologous protein (CHOP), which mediates endoplasmic reticulum stress-induced apoptosis.
16	20424162	Both CHOP mRNA and protein increase in beta cells treated with IL-1beta.
17	20424162	IL-1beta also causes increased expression of C/EBP-beta and a reduction of MafA, NFATc2, and Pdx-1 expression in beta cells.
18	20424162	Inhibition of the NF-kappaB and MAPK signaling pathways differentially attenuates CHOP expression.