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Gene Information
Gene symbol: NIT2
Gene name: nitrilase family, member 2
HGNC ID: 29878
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CPE | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15618358 | Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells. |
| 2 | 15618358 | Islet amyloid polypeptide (IAPP; amylin) is a peptide hormone that is cosecreted with insulin from beta-cells. |
| 3 | 15618358 | In this study, we investigated the role of carboxypeptidase E (CPE) in the processing of proIAPP using mice lacking active CPE (Cpe(fat)/Cpe(fat)) and NIT-2 cells, a beta-cell line derived from their islets. |
| 4 | 15618358 | Impaired proIAPP processing was associated with a decrease in PC2 (but not PC1/3) and both the 21- and 27-kDa forms of the PC2 chaperone protein 7B2, suggesting that PC2-mediated processing of proIAPP at its NH(2) terminus was impaired in the absence of CPE. |
| 5 | 15618358 | We conclude that lack of CPE in islet beta-cells results in a marked decrease in processing of proIAPP at its NH(2) (but not COOH) terminus that is associated with attenuated levels of PC2 and (pro)7B2 and a great reduction in formation of mature amidated IAPP. |