Ignet

Gene Information

Gene symbol: NR0B1

Gene name: nuclear receptor subfamily 0, group B, member 1

HGNC ID: 7960

Synonyms: DAX1, AHCH

Related Genes

#	Gene Symbol	Number of hits
1	AVP	1 hits
2	CDAN1	1 hits
3	CYP11A1	1 hits
4	CYP2B6	1 hits
5	ESRRB	1 hits
6	FGR	1 hits
7	HFE	1 hits
8	INS	1 hits
9	INSR	1 hits
10	NCOA2	1 hits
11	NR5A1	1 hits
12	PHP	1 hits
13	POMC	1 hits
14	SF1	1 hits
15	SRA1	1 hits
16	SSRP1	1 hits
17	STAR	1 hits
18	TBXAS1	1 hits

Related Sentences

#	PMID	Sentence
1	727728	A 63-year-old woman with longstanding spastic paraplegia and neurological evidence of long tract disturbance was found to have hypothyroidism, partial diabetes insipidus, hyperprolactinemia, and gonadotropin deficiency of hypothalamic origin.
2	7958084	[Isolated gonadotropin deficiency and secretory discrepancy of cortisol and adrenal androgen by hemochromatosis secondary to congenital dyserythropoietic anemia].
3	7958084	Serological and hematological examinations revealed that she suffered from hemochromatosis secondary to congenital dyserythropoietic anemia (CDA), characterized by ineffective hematopoiesis and erythropoietic dysplasia.
4	8180439	Unusual combination of insulin-dependent diabetes mellitus with transient-pituitary-isolated gonadotropin deficiency.
5	8180439	We report a 27-year-old man with insulin-dependent diabetes mellitus and transient-pituitary-isolated gonadotropin deficiency.
6	8180439	We suspected that both insulin-dependent diabetes mellitus and transient-gonadotropin-deficiency might be an autoimmune mechanism.
7	8180439	Unusual combination of insulin-dependent diabetes mellitus with transient-pituitary-isolated gonadotropin deficiency.
8	8180439	We report a 27-year-old man with insulin-dependent diabetes mellitus and transient-pituitary-isolated gonadotropin deficiency.
9	8180439	We suspected that both insulin-dependent diabetes mellitus and transient-gonadotropin-deficiency might be an autoimmune mechanism.
10	8180439	Unusual combination of insulin-dependent diabetes mellitus with transient-pituitary-isolated gonadotropin deficiency.
11	8180439	We report a 27-year-old man with insulin-dependent diabetes mellitus and transient-pituitary-isolated gonadotropin deficiency.
12	8180439	We suspected that both insulin-dependent diabetes mellitus and transient-gonadotropin-deficiency might be an autoimmune mechanism.
13	9667058	The most relevant clinical aspects of hyperprolactinemia, acromegaly, Cushing's disease, secondary hyperthyroidism, syndrome of inappropriate ADH secretion, panhypopituitarism, growth hormone deficiency, gonadotropin deficiency, ACTH deficiency, TSH deficiency, and diabetes insipidus are discussed.
14	9747063	Insulin resistance in patients with Klinefelter's syndrome and idiopathic gonadotropin deficiency.
15	12083815	Adrenal hypoplasia congenita with multiple pituitary hormone deficiency without documented mutation in DAX1 or SF1 gene.
16	12083815	A boy with adrenal hypoplasia congenita (AHC) and multiple pituitary hormone deficiency (MPHD), without mutations in the DAX1 or SF1 genes, is described.
17	12083815	Adrenal hypoplasia congenita with multiple pituitary hormone deficiency without documented mutation in DAX1 or SF1 gene.
18	12083815	A boy with adrenal hypoplasia congenita (AHC) and multiple pituitary hormone deficiency (MPHD), without mutations in the DAX1 or SF1 genes, is described.
19	12704802	Many of the observed differences, including down-regulation of collagen type I and collagen-processing enzymes, reflect expected patterns and support the relevance of our results.
20	12704802	These include an orphan nuclear receptor DAX1 and a small ras-related GTPase associated with diabetes, both of which increased with increasing differentiation, as well as a high mobility group-box transcription factor, SOX4, that was down-regulated during differentiation.
21	12727972	We have synthesized the human N-terminal POMC fragment 1-28-POMC with the disulfide bridges in the correct position between cysteine residues 2-24 and 8-20 and studied the activity of these peptides in adrenocortical tumor cells in vitro. 1-28-POMC stimulated cell proliferation in human NCI-h295 and mouse Y-1 adrenal cancer cell lines and also in primary cultures of bovine adrenocortical cells in a concentration-dependent manner. 1-28-POMC led to rapid activation of the MAPKs extracellular signal-regulated kinases-1 and -2, but not c-Jun N-terminal kinase and p38, pathways.
22	12727972	However, protein levels of important regulators of steroidogenesis [steroidogenic factor-1, DAX-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X-chromosome 1), steroidogenic acute regulatory protein, and cytochrome P450 side-chain cleavage enzyme] remained unaffected by 1-28-POMC treatment.
23	16353672	In contrast, increased insulin resistance was found in both hypergonadotropic and hypogonadotropic men with hypoandrogenism, patients with Klinefelter's syndrome and men with idiopathic gonadotropin deficiency.
24	16786802	Endocrine tests demonstrated a growth hormone and gonadotropin deficiency with diabetes insipidus.
25	19000767	Thyroid hormones exert most of their physiological effects through two thyroid hormone receptor (TR) subtypes, TRalpha and TRbeta, which associate with many transcriptional coregulators to mediate activation or repression of target genes.
26	19000767	Here, we present a new methodology which employs surface plasmon resonance to investigate the interactions between TRbeta ligand binding domain (LBD) complexes and peptides derived from the nuclear receptor interaction motifs of two of its coregulators, SRC2 and DAX1.
27	19188450	Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis.
28	19188450	The atypical orphan nuclear receptor Dax-1 binds to SF-1 and represses SF-1 target genes.
29	19188450	Paradoxically, however, loss-of-function mutations of Dax-1 also cause adrenal hypoplasia, suggesting that Dax-1 may function as an SF-1 coactivator under some circumstances.
30	19188450	Indeed, we found that Dax-1 can function as a dosage-dependent SF-1 coactivator.
31	19188450	Both SF-1 and Dax-1 bind to steroid receptor RNA activator (SRA), a coactivator that functions as an RNA.
32	19188450	The coactivator TIF2 also associates with Dax-1 and synergistically coactivates SF-1 target gene transcription.
33	19188450	Coactivation by Dax-1 is abolished by SRA knockdown.
34	19188450	The expression of the steroidogenic gene products steroidogenic acute regulatory protein (StAR) and melanocortin 2 receptor is reduced in adrenal Y1 cells following the knockdown of endogenous SRA.
35	19188450	Similarly, the knockdown of endogenous Dax-1 downregulates the expression of the steroidogenic gene products CYP11A1 and StAR in both H295R adrenal and MA-10 Leydig cells.
36	19188450	These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology.
37	19188450	Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis.
38	19188450	The atypical orphan nuclear receptor Dax-1 binds to SF-1 and represses SF-1 target genes.
39	19188450	Paradoxically, however, loss-of-function mutations of Dax-1 also cause adrenal hypoplasia, suggesting that Dax-1 may function as an SF-1 coactivator under some circumstances.
40	19188450	Indeed, we found that Dax-1 can function as a dosage-dependent SF-1 coactivator.
41	19188450	Both SF-1 and Dax-1 bind to steroid receptor RNA activator (SRA), a coactivator that functions as an RNA.
42	19188450	The coactivator TIF2 also associates with Dax-1 and synergistically coactivates SF-1 target gene transcription.
43	19188450	Coactivation by Dax-1 is abolished by SRA knockdown.
44	19188450	The expression of the steroidogenic gene products steroidogenic acute regulatory protein (StAR) and melanocortin 2 receptor is reduced in adrenal Y1 cells following the knockdown of endogenous SRA.
45	19188450	Similarly, the knockdown of endogenous Dax-1 downregulates the expression of the steroidogenic gene products CYP11A1 and StAR in both H295R adrenal and MA-10 Leydig cells.
46	19188450	These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology.
47	19188450	Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis.
48	19188450	The atypical orphan nuclear receptor Dax-1 binds to SF-1 and represses SF-1 target genes.
49	19188450	Paradoxically, however, loss-of-function mutations of Dax-1 also cause adrenal hypoplasia, suggesting that Dax-1 may function as an SF-1 coactivator under some circumstances.
50	19188450	Indeed, we found that Dax-1 can function as a dosage-dependent SF-1 coactivator.
51	19188450	Both SF-1 and Dax-1 bind to steroid receptor RNA activator (SRA), a coactivator that functions as an RNA.
52	19188450	The coactivator TIF2 also associates with Dax-1 and synergistically coactivates SF-1 target gene transcription.
53	19188450	Coactivation by Dax-1 is abolished by SRA knockdown.
54	19188450	The expression of the steroidogenic gene products steroidogenic acute regulatory protein (StAR) and melanocortin 2 receptor is reduced in adrenal Y1 cells following the knockdown of endogenous SRA.
55	19188450	Similarly, the knockdown of endogenous Dax-1 downregulates the expression of the steroidogenic gene products CYP11A1 and StAR in both H295R adrenal and MA-10 Leydig cells.
56	19188450	These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology.
57	19188450	Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis.
58	19188450	The atypical orphan nuclear receptor Dax-1 binds to SF-1 and represses SF-1 target genes.
59	19188450	Paradoxically, however, loss-of-function mutations of Dax-1 also cause adrenal hypoplasia, suggesting that Dax-1 may function as an SF-1 coactivator under some circumstances.
60	19188450	Indeed, we found that Dax-1 can function as a dosage-dependent SF-1 coactivator.
61	19188450	Both SF-1 and Dax-1 bind to steroid receptor RNA activator (SRA), a coactivator that functions as an RNA.
62	19188450	The coactivator TIF2 also associates with Dax-1 and synergistically coactivates SF-1 target gene transcription.
63	19188450	Coactivation by Dax-1 is abolished by SRA knockdown.
64	19188450	The expression of the steroidogenic gene products steroidogenic acute regulatory protein (StAR) and melanocortin 2 receptor is reduced in adrenal Y1 cells following the knockdown of endogenous SRA.
65	19188450	Similarly, the knockdown of endogenous Dax-1 downregulates the expression of the steroidogenic gene products CYP11A1 and StAR in both H295R adrenal and MA-10 Leydig cells.
66	19188450	These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology.
67	19188450	Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis.
68	19188450	The atypical orphan nuclear receptor Dax-1 binds to SF-1 and represses SF-1 target genes.
69	19188450	Paradoxically, however, loss-of-function mutations of Dax-1 also cause adrenal hypoplasia, suggesting that Dax-1 may function as an SF-1 coactivator under some circumstances.
70	19188450	Indeed, we found that Dax-1 can function as a dosage-dependent SF-1 coactivator.
71	19188450	Both SF-1 and Dax-1 bind to steroid receptor RNA activator (SRA), a coactivator that functions as an RNA.
72	19188450	The coactivator TIF2 also associates with Dax-1 and synergistically coactivates SF-1 target gene transcription.
73	19188450	Coactivation by Dax-1 is abolished by SRA knockdown.
74	19188450	The expression of the steroidogenic gene products steroidogenic acute regulatory protein (StAR) and melanocortin 2 receptor is reduced in adrenal Y1 cells following the knockdown of endogenous SRA.
75	19188450	Similarly, the knockdown of endogenous Dax-1 downregulates the expression of the steroidogenic gene products CYP11A1 and StAR in both H295R adrenal and MA-10 Leydig cells.
76	19188450	These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology.
77	19188450	Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis.
78	19188450	The atypical orphan nuclear receptor Dax-1 binds to SF-1 and represses SF-1 target genes.
79	19188450	Paradoxically, however, loss-of-function mutations of Dax-1 also cause adrenal hypoplasia, suggesting that Dax-1 may function as an SF-1 coactivator under some circumstances.
80	19188450	Indeed, we found that Dax-1 can function as a dosage-dependent SF-1 coactivator.
81	19188450	Both SF-1 and Dax-1 bind to steroid receptor RNA activator (SRA), a coactivator that functions as an RNA.
82	19188450	The coactivator TIF2 also associates with Dax-1 and synergistically coactivates SF-1 target gene transcription.
83	19188450	Coactivation by Dax-1 is abolished by SRA knockdown.
84	19188450	The expression of the steroidogenic gene products steroidogenic acute regulatory protein (StAR) and melanocortin 2 receptor is reduced in adrenal Y1 cells following the knockdown of endogenous SRA.
85	19188450	Similarly, the knockdown of endogenous Dax-1 downregulates the expression of the steroidogenic gene products CYP11A1 and StAR in both H295R adrenal and MA-10 Leydig cells.
86	19188450	These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology.
87	19188450	Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis.
88	19188450	The atypical orphan nuclear receptor Dax-1 binds to SF-1 and represses SF-1 target genes.
89	19188450	Paradoxically, however, loss-of-function mutations of Dax-1 also cause adrenal hypoplasia, suggesting that Dax-1 may function as an SF-1 coactivator under some circumstances.
90	19188450	Indeed, we found that Dax-1 can function as a dosage-dependent SF-1 coactivator.
91	19188450	Both SF-1 and Dax-1 bind to steroid receptor RNA activator (SRA), a coactivator that functions as an RNA.
92	19188450	The coactivator TIF2 also associates with Dax-1 and synergistically coactivates SF-1 target gene transcription.
93	19188450	Coactivation by Dax-1 is abolished by SRA knockdown.
94	19188450	The expression of the steroidogenic gene products steroidogenic acute regulatory protein (StAR) and melanocortin 2 receptor is reduced in adrenal Y1 cells following the knockdown of endogenous SRA.
95	19188450	Similarly, the knockdown of endogenous Dax-1 downregulates the expression of the steroidogenic gene products CYP11A1 and StAR in both H295R adrenal and MA-10 Leydig cells.
96	19188450	These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology.
97	19188450	Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis.
98	19188450	The atypical orphan nuclear receptor Dax-1 binds to SF-1 and represses SF-1 target genes.
99	19188450	Paradoxically, however, loss-of-function mutations of Dax-1 also cause adrenal hypoplasia, suggesting that Dax-1 may function as an SF-1 coactivator under some circumstances.
100	19188450	Indeed, we found that Dax-1 can function as a dosage-dependent SF-1 coactivator.
101	19188450	Both SF-1 and Dax-1 bind to steroid receptor RNA activator (SRA), a coactivator that functions as an RNA.
102	19188450	The coactivator TIF2 also associates with Dax-1 and synergistically coactivates SF-1 target gene transcription.
103	19188450	Coactivation by Dax-1 is abolished by SRA knockdown.
104	19188450	The expression of the steroidogenic gene products steroidogenic acute regulatory protein (StAR) and melanocortin 2 receptor is reduced in adrenal Y1 cells following the knockdown of endogenous SRA.
105	19188450	Similarly, the knockdown of endogenous Dax-1 downregulates the expression of the steroidogenic gene products CYP11A1 and StAR in both H295R adrenal and MA-10 Leydig cells.
106	19188450	These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology.
107	19188450	Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis.
108	19188450	The atypical orphan nuclear receptor Dax-1 binds to SF-1 and represses SF-1 target genes.
109	19188450	Paradoxically, however, loss-of-function mutations of Dax-1 also cause adrenal hypoplasia, suggesting that Dax-1 may function as an SF-1 coactivator under some circumstances.
110	19188450	Indeed, we found that Dax-1 can function as a dosage-dependent SF-1 coactivator.
111	19188450	Both SF-1 and Dax-1 bind to steroid receptor RNA activator (SRA), a coactivator that functions as an RNA.
112	19188450	The coactivator TIF2 also associates with Dax-1 and synergistically coactivates SF-1 target gene transcription.
113	19188450	Coactivation by Dax-1 is abolished by SRA knockdown.
114	19188450	The expression of the steroidogenic gene products steroidogenic acute regulatory protein (StAR) and melanocortin 2 receptor is reduced in adrenal Y1 cells following the knockdown of endogenous SRA.
115	19188450	Similarly, the knockdown of endogenous Dax-1 downregulates the expression of the steroidogenic gene products CYP11A1 and StAR in both H295R adrenal and MA-10 Leydig cells.
116	19188450	These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology.
117	21318063	A diagnosis of central diabetes insipidus (CDI) accompanied by growth hormone (GH) and gonadotropin deficiency was made.
118	23589295	Insulin directly regulates steroidogenesis via induction of the orphan nuclear receptor DAX-1 in testicular Leydig cells.
119	23589295	In this study, we found that insulin directly binds to insulin receptors in Leydig cell membranes and activates phospho-insulin receptor-β (phospho-IR-β), phospho-IRS1, and phospho-AKT, leading to up-regulation of DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) gene expression in the MA-10 mouse Leydig cell line.
120	23589295	Insulin also inhibits cAMP-induced and liver receptor homolog-1 (LRH-1)-induced steroidogenic enzyme gene expression and steroidogenesis.
121	23589295	In contrast, knockdown of DAX-1 reversed insulin-mediated inhibition of steroidogenesis.
122	23589295	In insulin-injected mouse models, insulin receptor signal pathway was activated and subsequently inhibited steroidogenesis via induction of DAX-1 without significant change of luteinizing hormone or FSH levels.
123	23589295	Insulin-mediated induction of DAX-1 in Leydig cells of testis may be a key regulatory step of serum sex hormone level in insulin-resistant states.
124	23589295	Insulin directly regulates steroidogenesis via induction of the orphan nuclear receptor DAX-1 in testicular Leydig cells.
125	23589295	In this study, we found that insulin directly binds to insulin receptors in Leydig cell membranes and activates phospho-insulin receptor-β (phospho-IR-β), phospho-IRS1, and phospho-AKT, leading to up-regulation of DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) gene expression in the MA-10 mouse Leydig cell line.
126	23589295	Insulin also inhibits cAMP-induced and liver receptor homolog-1 (LRH-1)-induced steroidogenic enzyme gene expression and steroidogenesis.
127	23589295	In contrast, knockdown of DAX-1 reversed insulin-mediated inhibition of steroidogenesis.
128	23589295	In insulin-injected mouse models, insulin receptor signal pathway was activated and subsequently inhibited steroidogenesis via induction of DAX-1 without significant change of luteinizing hormone or FSH levels.
129	23589295	Insulin-mediated induction of DAX-1 in Leydig cells of testis may be a key regulatory step of serum sex hormone level in insulin-resistant states.
130	23589295	Insulin directly regulates steroidogenesis via induction of the orphan nuclear receptor DAX-1 in testicular Leydig cells.
131	23589295	In this study, we found that insulin directly binds to insulin receptors in Leydig cell membranes and activates phospho-insulin receptor-β (phospho-IR-β), phospho-IRS1, and phospho-AKT, leading to up-regulation of DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) gene expression in the MA-10 mouse Leydig cell line.
132	23589295	Insulin also inhibits cAMP-induced and liver receptor homolog-1 (LRH-1)-induced steroidogenic enzyme gene expression and steroidogenesis.
133	23589295	In contrast, knockdown of DAX-1 reversed insulin-mediated inhibition of steroidogenesis.
134	23589295	In insulin-injected mouse models, insulin receptor signal pathway was activated and subsequently inhibited steroidogenesis via induction of DAX-1 without significant change of luteinizing hormone or FSH levels.
135	23589295	Insulin-mediated induction of DAX-1 in Leydig cells of testis may be a key regulatory step of serum sex hormone level in insulin-resistant states.
136	23589295	Insulin directly regulates steroidogenesis via induction of the orphan nuclear receptor DAX-1 in testicular Leydig cells.
137	23589295	In this study, we found that insulin directly binds to insulin receptors in Leydig cell membranes and activates phospho-insulin receptor-β (phospho-IR-β), phospho-IRS1, and phospho-AKT, leading to up-regulation of DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) gene expression in the MA-10 mouse Leydig cell line.
138	23589295	Insulin also inhibits cAMP-induced and liver receptor homolog-1 (LRH-1)-induced steroidogenic enzyme gene expression and steroidogenesis.
139	23589295	In contrast, knockdown of DAX-1 reversed insulin-mediated inhibition of steroidogenesis.
140	23589295	In insulin-injected mouse models, insulin receptor signal pathway was activated and subsequently inhibited steroidogenesis via induction of DAX-1 without significant change of luteinizing hormone or FSH levels.
141	23589295	Insulin-mediated induction of DAX-1 in Leydig cells of testis may be a key regulatory step of serum sex hormone level in insulin-resistant states.
142	23589295	Insulin directly regulates steroidogenesis via induction of the orphan nuclear receptor DAX-1 in testicular Leydig cells.
143	23589295	In this study, we found that insulin directly binds to insulin receptors in Leydig cell membranes and activates phospho-insulin receptor-β (phospho-IR-β), phospho-IRS1, and phospho-AKT, leading to up-regulation of DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) gene expression in the MA-10 mouse Leydig cell line.
144	23589295	Insulin also inhibits cAMP-induced and liver receptor homolog-1 (LRH-1)-induced steroidogenic enzyme gene expression and steroidogenesis.
145	23589295	In contrast, knockdown of DAX-1 reversed insulin-mediated inhibition of steroidogenesis.
146	23589295	In insulin-injected mouse models, insulin receptor signal pathway was activated and subsequently inhibited steroidogenesis via induction of DAX-1 without significant change of luteinizing hormone or FSH levels.
147	23589295	Insulin-mediated induction of DAX-1 in Leydig cells of testis may be a key regulatory step of serum sex hormone level in insulin-resistant states.