Ignet

Gene Information

Gene symbol: NR4A2

Gene name: nuclear receptor subfamily 4, group A, member 2

HGNC ID: 7981

Synonyms: TINUR, NOT, RNR1, HZF-3

Related Genes

#	Gene Symbol	Number of hits
1	ALPI	1 hits
2	ALPP	1 hits
3	BGLAP	1 hits
4	CD79A	1 hits
5	COL1A1	1 hits
6	EN1	1 hits
7	ESRRB	1 hits
8	LMX1B	1 hits
9	NGF	1 hits
10	NR4A1	1 hits
11	NR4A3	1 hits
12	SNCA	1 hits
13	SOD1	1 hits
14	TH	1 hits

Related Sentences

#	PMID	Sentence
1	8923536	Distribution of messenger RNAs for the orphan nuclear receptors Nurr1 and Nur77 (NGFI-B) in adult rat brain using in situ hybridization.
2	8923536	Nurr1 and Nur77 (NGFI-B) are orphan nuclear receptors, belonging to the steroid/thyroid hormone receptor gene superfamily.
3	8923536	Our results show that Nurr1 and Nur77 messenger RNAs have both overlapping and different distribution patterns within the brain, suggesting that they might regulate different sets of responsive genes.
4	8923536	Distribution of messenger RNAs for the orphan nuclear receptors Nurr1 and Nur77 (NGFI-B) in adult rat brain using in situ hybridization.
5	8923536	Nurr1 and Nur77 (NGFI-B) are orphan nuclear receptors, belonging to the steroid/thyroid hormone receptor gene superfamily.
6	8923536	Our results show that Nurr1 and Nur77 messenger RNAs have both overlapping and different distribution patterns within the brain, suggesting that they might regulate different sets of responsive genes.
7	8923536	Distribution of messenger RNAs for the orphan nuclear receptors Nurr1 and Nur77 (NGFI-B) in adult rat brain using in situ hybridization.
8	8923536	Nurr1 and Nur77 (NGFI-B) are orphan nuclear receptors, belonging to the steroid/thyroid hormone receptor gene superfamily.
9	8923536	Our results show that Nurr1 and Nur77 messenger RNAs have both overlapping and different distribution patterns within the brain, suggesting that they might regulate different sets of responsive genes.
10	9143501	Although the exon/intron structure of Nurr1 is nearly identical to that of Nur77, Nurr1 possesses an additional untranslated exon.
11	9143501	These data help to explain the different response characteristics of two closely related early response genes, Nurr1 and Nur77.
12	9143501	Although the exon/intron structure of Nurr1 is nearly identical to that of Nur77, Nurr1 possesses an additional untranslated exon.
13	9143501	These data help to explain the different response characteristics of two closely related early response genes, Nurr1 and Nur77.
14	9572393	A divergent role of COOH-terminal domains in Nurr1 and Nur77 transactivation.
15	9572393	Orphan nuclear receptors such as Nurr1 and Nur77 have conserved amino acid sequences in the zinc finger DNA binding domains and similar COOH-terminal regions, but have no known ligands.
16	9572393	Nurr1, Nur77, and 3'-truncated mutants bind in gel mobility shift assays to the monomeric Nur77 response element (B1A-RE).
17	9572393	Unlike full-length Nurr1 and Nur77, transactivation by Nur77-586 was not augmented in response to the presence of retinoid-like receptor and 9-cis-retinoic acid.
18	9572393	Thus, the interaction of putative ligand binding and transactivation for Nurr1 and Nur77 may function differently.
19	9572393	A divergent role of COOH-terminal domains in Nurr1 and Nur77 transactivation.
20	9572393	Orphan nuclear receptors such as Nurr1 and Nur77 have conserved amino acid sequences in the zinc finger DNA binding domains and similar COOH-terminal regions, but have no known ligands.
21	9572393	Nurr1, Nur77, and 3'-truncated mutants bind in gel mobility shift assays to the monomeric Nur77 response element (B1A-RE).
22	9572393	Unlike full-length Nurr1 and Nur77, transactivation by Nur77-586 was not augmented in response to the presence of retinoid-like receptor and 9-cis-retinoic acid.
23	9572393	Thus, the interaction of putative ligand binding and transactivation for Nurr1 and Nur77 may function differently.
24	9572393	A divergent role of COOH-terminal domains in Nurr1 and Nur77 transactivation.
25	9572393	Orphan nuclear receptors such as Nurr1 and Nur77 have conserved amino acid sequences in the zinc finger DNA binding domains and similar COOH-terminal regions, but have no known ligands.
26	9572393	Nurr1, Nur77, and 3'-truncated mutants bind in gel mobility shift assays to the monomeric Nur77 response element (B1A-RE).
27	9572393	Unlike full-length Nurr1 and Nur77, transactivation by Nur77-586 was not augmented in response to the presence of retinoid-like receptor and 9-cis-retinoic acid.
28	9572393	Thus, the interaction of putative ligand binding and transactivation for Nurr1 and Nur77 may function differently.
29	9572393	A divergent role of COOH-terminal domains in Nurr1 and Nur77 transactivation.
30	9572393	Orphan nuclear receptors such as Nurr1 and Nur77 have conserved amino acid sequences in the zinc finger DNA binding domains and similar COOH-terminal regions, but have no known ligands.
31	9572393	Nurr1, Nur77, and 3'-truncated mutants bind in gel mobility shift assays to the monomeric Nur77 response element (B1A-RE).
32	9572393	Unlike full-length Nurr1 and Nur77, transactivation by Nur77-586 was not augmented in response to the presence of retinoid-like receptor and 9-cis-retinoic acid.
33	9572393	Thus, the interaction of putative ligand binding and transactivation for Nurr1 and Nur77 may function differently.
34	9572393	A divergent role of COOH-terminal domains in Nurr1 and Nur77 transactivation.
35	9572393	Orphan nuclear receptors such as Nurr1 and Nur77 have conserved amino acid sequences in the zinc finger DNA binding domains and similar COOH-terminal regions, but have no known ligands.
36	9572393	Nurr1, Nur77, and 3'-truncated mutants bind in gel mobility shift assays to the monomeric Nur77 response element (B1A-RE).
37	9572393	Unlike full-length Nurr1 and Nur77, transactivation by Nur77-586 was not augmented in response to the presence of retinoid-like receptor and 9-cis-retinoic acid.
38	9572393	Thus, the interaction of putative ligand binding and transactivation for Nurr1 and Nur77 may function differently.
39	11340638	Disruption of the Nurr1 gene in mice by homologous recombination abolishes synthesis of dopamine (DA) and expression of DA biosynthetic enzymes, including tyrosine hydroxylase (TH), in the ventral midbrain without affecting the synthesis of DA in other areas of the brain.
40	11340638	No change in TH expression was observed in the presence of glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), or DA alone or in combination.
41	12385813	Nurr1, an orphan nuclear receptor, is essential for the differentiation of the midbrain dopamine (DA) neurons; however, its function in adult midbrain DA neurons has not been determined.
42	12678688	The current review summarizes results from knockout mice with the target disruption of genes involved in the development of DA neurons (engrailed 1 and 2, lmx1b, and Nurr1), in maintaining DA neurotransmission (tyrosine hydroxylase, vesicular monoamine transporter, DA transporter, DA D2 and D3 receptors) and important for DA neuron survival (alpha-synuclein, glia cell line-derived neurotrophic factor and superoxide dismutase).
43	16741951	Our results revealed that reduced Nurr1 expression, using Nurr1 siRNA in MC3T3-E1 cells, affected the expression of osteoblast differentiation marker genes, osteocalcin (OCN) and collagen type I alpha 1 (COL1A1), as measured by quantitative real-time PCR.
44	16741951	The activity of alkaline phosphatase (ALP), another osteoblast differentiation marker gene, was also decreased in Nurr1 siRNA-treated MC3T3-E1 cells.
45	16741951	In addition, Nurr1 overexpression increased OCN and COL1A1 expression.
46	16741951	Our results revealed that reduced Nurr1 expression, using Nurr1 siRNA in MC3T3-E1 cells, affected the expression of osteoblast differentiation marker genes, osteocalcin (OCN) and collagen type I alpha 1 (COL1A1), as measured by quantitative real-time PCR.
47	16741951	The activity of alkaline phosphatase (ALP), another osteoblast differentiation marker gene, was also decreased in Nurr1 siRNA-treated MC3T3-E1 cells.
48	16741951	In addition, Nurr1 overexpression increased OCN and COL1A1 expression.
49	16741951	Our results revealed that reduced Nurr1 expression, using Nurr1 siRNA in MC3T3-E1 cells, affected the expression of osteoblast differentiation marker genes, osteocalcin (OCN) and collagen type I alpha 1 (COL1A1), as measured by quantitative real-time PCR.
50	16741951	The activity of alkaline phosphatase (ALP), another osteoblast differentiation marker gene, was also decreased in Nurr1 siRNA-treated MC3T3-E1 cells.
51	16741951	In addition, Nurr1 overexpression increased OCN and COL1A1 expression.
52	16906154	Hepatic expression of Nur77, Nurr1 and NOR1 is induced by the cAMP axis in response to glucagon and fasting in vivo and is increased in diabetic mice that exhibit elevated gluconeogenesis.
53	17394463	Additional analysis using 5'-deletions and mutants revealed that Nurr1 activates GTPCH transcription indirectly through the proximal promoter region, in the absence of the nerve growth factor-induced clone B (NGFI-B) responsive element-like sites, similarly, as recently reported for DA transporter regulation by Nurr1.
54	18293283	An asymptomatic 70-year-old Hispanic woman with type 2 diabetes was found in 2004 to have an AST of 132 U/L, ALT 146 U/L, alkaline phosphatase 1107 U/L, total serum bilirubin 3.5 mg/dL, and albumin 2.9 g/dL.
55	18293283	Serum IgG and IgA, but NOT IgM, were elevated.
56	20392876	The orphan NR4A subgroup includes Nur77 (NR4A1), Nurr1 (NR4A2), and Nor-1 (NR4A3).