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Gene Information
Gene symbol: NRL
Gene name: neural retina leucine zipper
HGNC ID: 8002
Synonyms: D14S46E, RP27, NRL-MAF
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CRX | 1 hits |
| 2 | RHOD | 1 hits |
| 3 | RORB | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19805139 | Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. |
| 2 | 19805139 | Here, we report that Rorb(-/-) mice lacking retinoid-related orphan nuclear receptor beta lose rods but overproduce primitive S cones that lack outer segments. |
| 3 | 19805139 | Rorb(-/-) mice lack Nrl expression and reexpression of Nrl in Rorb(-/-) mice converts cones to rod-like cells. |
| 4 | 23646198 | Ablation of C/EBP homologous protein does not protect T17M RHO mice from retinal degeneration. |
| 5 | 23646198 | The purpose of this study is to investigate the role of CHOP protein in T17M RHO retina. |
| 6 | 23646198 | Wild-type, CHOP-/-, T17M RHO and T17M RHO CHOP-/-mice were used in the study. |
| 7 | 23646198 | Dark-adapted ERG analysis demonstrated that by 1 month, the T17M RHO CHOP-/- mice had a 70% reduction of the a-wave amplitude compared to the T17M RHO mice. |
| 8 | 23646198 | The loss of function in T17M RHO CHOP-/- photoreceptors was associated with a 22-24% decline in the thickness of the outer nuclear layer. |
| 9 | 23646198 | These mice had significant reduction in the expression of transcription factors, Crx and Nrl, and also in mouse Rho, and human RHO. |
| 10 | 23646198 | In addition, the histone deacetylase 1 (Hdac1) protein was 2-fold elevated in the T17M RHO CHOP-/- retina. |
| 11 | 23646198 | The ablation of CHOP led to a reduction in the expression of photoreceptor-specific transcriptional factors, and both endogenous and exogenous RHO mRNA. |