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Gene Information
Gene symbol: NUDT10
Gene name: nudix (nucleoside diphosphate linked moiety X)-type motif 10
HGNC ID: 17621
Synonyms: DIPP3a, hDIPP3alpha
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AIRE | 1 hits |
| 2 | CYP11A1 | 1 hits |
| 3 | CYP17A1 | 1 hits |
| 4 | FOXP3 | 1 hits |
| 5 | GAD1 | 1 hits |
| 6 | GAD2 | 1 hits |
| 7 | IDDM2 | 1 hits |
| 8 | INS | 1 hits |
| 9 | POF1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10594551 | Autoantibodies to GAD, an important marker of the autoimmune process in type I or insulin-dependent diabetes mellitus (IDDM), are also found in non-diabetic individuals with autoimmune polyendocrine syndrome type 1 (APS1), APS2, and stiff man syndrome (SMS). |
| 2 | 10594551 | Most IDDM sera contain two distinct GAD antibody specificities, one of which targets an epitope region in the middle-third of GAD65 (IDDM-E1; amino acids 221-359) and one of which targets the carboxy-third of GAD65 (IDDM-E2; amino acids 453-569). |
| 3 | 10594551 | Using 11 chimeric GAD65/GAD67 proteins to maintain conformation-dependent epitopes of GAD65, we compared the humoral repertoire of IgG antibodies from an individual with APS2-like disease (b35, b78, and b96) and MoAbs from an IDDM patient (MICA-2, MICA-3, and MICA-4). |
| 4 | 10594551 | Neither the APS2 IgG antibodies nor the IDDM MoAbs bind the amino-terminal third of GAD65, but instead target the carboxy-terminal two-thirds of GAD65. |
| 5 | 10594551 | These results indicate that there are both similarities and differences in the humoral response to GAD65 in APS2 and IDDM. |
| 6 | 10594551 | Autoantibodies to GAD, an important marker of the autoimmune process in type I or insulin-dependent diabetes mellitus (IDDM), are also found in non-diabetic individuals with autoimmune polyendocrine syndrome type 1 (APS1), APS2, and stiff man syndrome (SMS). |
| 7 | 10594551 | Most IDDM sera contain two distinct GAD antibody specificities, one of which targets an epitope region in the middle-third of GAD65 (IDDM-E1; amino acids 221-359) and one of which targets the carboxy-third of GAD65 (IDDM-E2; amino acids 453-569). |
| 8 | 10594551 | Using 11 chimeric GAD65/GAD67 proteins to maintain conformation-dependent epitopes of GAD65, we compared the humoral repertoire of IgG antibodies from an individual with APS2-like disease (b35, b78, and b96) and MoAbs from an IDDM patient (MICA-2, MICA-3, and MICA-4). |
| 9 | 10594551 | Neither the APS2 IgG antibodies nor the IDDM MoAbs bind the amino-terminal third of GAD65, but instead target the carboxy-terminal two-thirds of GAD65. |
| 10 | 10594551 | These results indicate that there are both similarities and differences in the humoral response to GAD65 in APS2 and IDDM. |
| 11 | 10852471 | The steroidogenic enzyme, 3beta-hydroxysteroid dehydrogenase (3betaHSD), has been characterized as a potential autoantigen in POF as well as in insulin-dependent diabetes mellitus (type 1 diabetes). |
| 12 | 10852471 | Here we studied the presence of steroid cell antibodies (SCA), autoantibodies to 3betaHSD and to two other known autoantigens in ovarian failure, steroidogenic enzymes 17alpha-hydroxylase (P450c17), and side-chain cleavage enzyme (P450scc) in POF patients and patient groups with autoimmune polyendocrinopathy syndromes type 1 and 2 (APS1 and -2), isolated Addison's disease, type 1 diabetes, and healthy controls. |
| 13 | 10852471 | The SCA were found in 2 of 48 POF, 11 of 15 APS1, and 1 of 9 APS2, and autoantibodies to in vitro translated 3betaHSD protein were detected in 1 POF serum associated with Addison's disease and 3 APS1 sera. |
| 14 | 10852471 | In analysis of autoantibodies to P450c17 and P450scc, antibodies to these enzymes were not found in POF sera, but were found in 10 and 12 APS1 patient sera, respectively, and 1 APS2 patient serum contained anti-P450c17 antibodies. |
| 15 | 10852471 | Our results show that autoantibodies to 3betaHSD in POF patients are rare and are also found in patients with APS1. |
| 16 | 19382992 | Autoimmune polyendocrine syndromes type 1 and 2 (APS-1 and APS-2) are diverse in regards to their component diseases and immunologic features of pathogenesis. |
| 17 | 20309000 | This Review discusses the genetic basis of APS-1, APS-2 and IPEX syndrome, with an emphasis on the mechanisms of autoimmunity and presents currently available therapies to treat their underlying autoimmune disorders. |