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Gene Information

Gene symbol: NUFIP2

Gene name: nuclear fragile X mental retardation protein interacting protein 2

HGNC ID: 17634

Synonyms: KIAA1321, MGC117262, PIG1, 182-FIP, FIP-82, 82-FIP

Related Genes

#	Gene Symbol	Number of hits
1	FMR1	1 hits
2	FXR1	1 hits

Related Sentences

#	PMID	Sentence
1	16886907	NF-Y, AP2, Nrf1 and Sp1 regulate the fragile X-related gene 2 (FXR2).
2	16886907	The protein product of this gene, FMRP (fragile X mental retardation protein), is thought to be involved in the translational regulation of mRNAs important for learning and memory.
3	16886907	Disruption of Fxr2 in mice produces learning and memory deficits, and Fmr1 and Fxr2 double-knockout mice have exaggerated impairments in certain neurobehavioral phenotypes relative to the single gene knockouts.
4	16886907	This has led to the suggestion that FMR1 and FXR2 functionally overlap and that increasing the expression of FXR2P may ameliorate the symptoms of an FMRP deficiency.
5	16886907	Interestingly, the region upstream of the FXR2 translation start site acts as a bidirectional promoter in rodents, driving transcription of an alternative transcript encoding the ABP (androgen-binding protein) [aABP (alternative ABP promoter)].
6	16886907	Gel electrophoretic mobility-shift assays, chromatin immunoprecipitation studies and co-transfection experiments with plasmids expressing these transcription factors or dominant-negative versions of these factors showed that NF-YA (nuclear transcription factor Yalpha), AP2 (activator protein 2), Nrf1 (nuclear respiratory factor/alpha-Pal) and Sp1 (specificity protein 1) all bind to the FXR2 promoter both in vitro and in vivo and positively regulate the FXR2 promoter.