Ignet

Gene Information

Gene symbol: ORAI1

Gene name: ORAI calcium release-activated calcium modulator 1

HGNC ID: 25896

Synonyms: FLJ14466, CRACM1

Related Genes

#	Gene Symbol	Number of hits
1	CFTR	1 hits
2	GRIK2	1 hits
3	KCNE1	1 hits
4	KCNJ1	1 hits
5	KCNQ1	1 hits
6	MBTPS1	1 hits
7	NAPA	1 hits
8	NFKB1	1 hits
9	NSF	1 hits
10	PRKAA2	1 hits
11	PRKAR2A	1 hits
12	S1PR3	1 hits
13	SCN5A	1 hits
14	SGK1	1 hits
15	SNAP25	1 hits
16	STIM1	1 hits
17	TRPC3	1 hits

Related Sentences

#	PMID	Sentence
1	18400989	Cleavage of the soluble N-ethylmaleimide-sensitive-factor attachment protein receptor, synaptosomal-assiciated protein-25 (SNAP-25), with botulinum neurotoxin A impaired TG-induced increase in the surface expression of Orai1.
2	18400989	In aggregate, these findings demonstrate that store depletion enhances Orai1 plasma membrane expression in an exocytotic manner that involves SNAP-25, a process that contributes to store-dependent Ca2+ entry.
3	18400989	Cleavage of the soluble N-ethylmaleimide-sensitive-factor attachment protein receptor, synaptosomal-assiciated protein-25 (SNAP-25), with botulinum neurotoxin A impaired TG-induced increase in the surface expression of Orai1.
4	18400989	In aggregate, these findings demonstrate that store depletion enhances Orai1 plasma membrane expression in an exocytotic manner that involves SNAP-25, a process that contributes to store-dependent Ca2+ entry.
5	19447651	Enhanced expression of STIM1/Orai1 and TRPC3 in platelets from patients with type 2 diabetes mellitus.
6	19447651	Expression of TRPC1, 3 and 6, STIM1 and Orai1 was analyzed by Western blotting in DM2 patients and controls.
7	19447651	We have found that expression of TRPC3, Orai1 and STIM1 is enhanced in DM2 subjects as compared to controls.
8	19447651	Enhanced expression of STIM1/Orai1 and TRPC3 in platelets from patients with type 2 diabetes mellitus.
9	19447651	Expression of TRPC1, 3 and 6, STIM1 and Orai1 was analyzed by Western blotting in DM2 patients and controls.
10	19447651	We have found that expression of TRPC3, Orai1 and STIM1 is enhanced in DM2 subjects as compared to controls.
11	19447651	Enhanced expression of STIM1/Orai1 and TRPC3 in platelets from patients with type 2 diabetes mellitus.
12	19447651	Expression of TRPC1, 3 and 6, STIM1 and Orai1 was analyzed by Western blotting in DM2 patients and controls.
13	19447651	We have found that expression of TRPC3, Orai1 and STIM1 is enhanced in DM2 subjects as compared to controls.
14	21270296	SOCE was observed in VSMCs lacking either S1P(2) or S1P(3) receptors, suggesting that S1P acts via multiple signaling pathways.
15	21270296	Finally, S1P-induced SOCE was larger in proliferative than in contractile VSMCs, correlating with increases in STIM1, Orai1, S1P(1), and S1P(3) receptor mRNA.
16	23527285	In the present study, we identified that the major endoplasmic reticulum stress (ERS) marker, Grp78 and ERS-induced apoptotic factor, CHOP, were time-dependently increased by exposure of β-TC3 cells to FFA.
17	23527285	The expression of ATF6 and the phosphorylation levels of PERK and IRE1, which trigger ERS signaling, markedly increased after FFA treatments.
18	23527285	We also found that FFA-induced ERS was mediated by the store-operated Ca(2+) entry through promoting the association of STIM1 and Orai1.
19	23527285	Moreover, calpain-2 was required for FFA-induced expression of CHOP and activation of caspase-12 and caspase-3, thus promoting cell apoptosis in β-TC3 cells.
20	23846758	Orai1 and STIM1 transcription is stimulated by NF-κB (nuclear factor kappa B).
21	23846758	Serum- and glucocorticoid-inducible kinase 1 (SGK1) up-regulates NF-κB-activity in megakaryocytes and thus Orai1-expression and SOCE in platelets.
22	23846758	Additional potential regulators of Orai1/STIM1 and thus SOCE in platelets include AMP activated kinase (AMPK), protein kinase A (PKA), reactive oxygen species, lipid rafts, pH and mitochondrial Ca2+ buffering.
23	23846758	Orai1 and STIM1 transcription is stimulated by NF-κB (nuclear factor kappa B).
24	23846758	Serum- and glucocorticoid-inducible kinase 1 (SGK1) up-regulates NF-κB-activity in megakaryocytes and thus Orai1-expression and SOCE in platelets.
25	23846758	Additional potential regulators of Orai1/STIM1 and thus SOCE in platelets include AMP activated kinase (AMPK), protein kinase A (PKA), reactive oxygen species, lipid rafts, pH and mitochondrial Ca2+ buffering.
26	23846758	Orai1 and STIM1 transcription is stimulated by NF-κB (nuclear factor kappa B).
27	23846758	Serum- and glucocorticoid-inducible kinase 1 (SGK1) up-regulates NF-κB-activity in megakaryocytes and thus Orai1-expression and SOCE in platelets.
28	23846758	Additional potential regulators of Orai1/STIM1 and thus SOCE in platelets include AMP activated kinase (AMPK), protein kinase A (PKA), reactive oxygen species, lipid rafts, pH and mitochondrial Ca2+ buffering.
29	23933686	SGK1 is activated by insulin and growth factors via phosphatidylinositol-3-kinase, 3-phosphoinositide dependent-kinase PDK1, and mTOR.
30	23933686	NCC, NKCC, NHE1, NHE3, SGLT1, several amino acid transporters) and many ion channels (e.g.
31	23933686	ENaC, SCN5A, TRPV4-6, Orai1/STIM1, ROMK, KCNE1/KCNQ1, GluR6, CFTR).
32	23933686	SGK1 further up-regulates a number of enzymes (e.g. glycogen-synthase-kinase-3, ubiquitin-ligase Nedd4-2), and transcription factors (e.g. forkhead-transcription-factor FOXO3a, β-catenin, nuclear-factor-kappa-B NFκB).