Ignet

Gene Information

Gene symbol: PASK

Gene name: PAS domain containing serine/threonine kinase

HGNC ID: 17270

Synonyms: PASKIN, KIAA0135, STK37

Related Genes

#	Gene Symbol	Number of hits
1	GTF2A1	1 hits
2	INS	1 hits
3	PPARGC1A	1 hits
4	PRKAA2	1 hits
5	RORC	1 hits

Related Sentences

#	PMID	Sentence
1	17192472	Glucose-stimulated insulin production in mice deficient for the PAS kinase PASKIN.
2	17192472	A recent report suggested that PASKIN mRNA, protein, and kinase activity are increased in pancreatic islet beta-cells under hyperglycemic conditions and that PASKIN is necessary for insulin gene expression.
3	17192472	Increasing glucose concentrations resulted in PASKIN-independent induction of insulin mRNA levels and insulin release.
4	17192472	These results suggest that Paskin gene expression is not induced by glucose in pancreatic beta-cells and that glucose-stimulated insulin production is independent of PASKIN.
5	17192472	Glucose-stimulated insulin production in mice deficient for the PAS kinase PASKIN.
6	17192472	A recent report suggested that PASKIN mRNA, protein, and kinase activity are increased in pancreatic islet beta-cells under hyperglycemic conditions and that PASKIN is necessary for insulin gene expression.
7	17192472	Increasing glucose concentrations resulted in PASKIN-independent induction of insulin mRNA levels and insulin release.
8	17192472	These results suggest that Paskin gene expression is not induced by glucose in pancreatic beta-cells and that glucose-stimulated insulin production is independent of PASKIN.
9	17192472	Glucose-stimulated insulin production in mice deficient for the PAS kinase PASKIN.
10	17192472	A recent report suggested that PASKIN mRNA, protein, and kinase activity are increased in pancreatic islet beta-cells under hyperglycemic conditions and that PASKIN is necessary for insulin gene expression.
11	17192472	Increasing glucose concentrations resulted in PASKIN-independent induction of insulin mRNA levels and insulin release.
12	17192472	These results suggest that Paskin gene expression is not induced by glucose in pancreatic beta-cells and that glucose-stimulated insulin production is independent of PASKIN.
13	17192472	Glucose-stimulated insulin production in mice deficient for the PAS kinase PASKIN.
14	17192472	A recent report suggested that PASKIN mRNA, protein, and kinase activity are increased in pancreatic islet beta-cells under hyperglycemic conditions and that PASKIN is necessary for insulin gene expression.
15	17192472	Increasing glucose concentrations resulted in PASKIN-independent induction of insulin mRNA levels and insulin release.
16	17192472	These results suggest that Paskin gene expression is not induced by glucose in pancreatic beta-cells and that glucose-stimulated insulin production is independent of PASKIN.
17	18344204	The cellular nutrient and energy sensors, AMPK and TOR, play a key role in maintaining cellular energy homeostasis.
18	18344204	Like AMPK and TOR, PAS kinase (PASK) is also a nutrient responsive protein kinase.
19	18344204	In cultured pancreatic beta-cells, PASK is activated by elevated glucose concentrations and is required for glucose-stimulated transcription of the insulin gene.
20	18344204	Interestingly, PGC-1 expression and AMPK and TOR activity were not affected in PASK deficient mice, suggesting PASK may exert its metabolic effects through a new mechanism.
21	18344204	The cellular nutrient and energy sensors, AMPK and TOR, play a key role in maintaining cellular energy homeostasis.
22	18344204	Like AMPK and TOR, PAS kinase (PASK) is also a nutrient responsive protein kinase.
23	18344204	In cultured pancreatic beta-cells, PASK is activated by elevated glucose concentrations and is required for glucose-stimulated transcription of the insulin gene.
24	18344204	Interestingly, PGC-1 expression and AMPK and TOR activity were not affected in PASK deficient mice, suggesting PASK may exert its metabolic effects through a new mechanism.
25	18344204	The cellular nutrient and energy sensors, AMPK and TOR, play a key role in maintaining cellular energy homeostasis.
26	18344204	Like AMPK and TOR, PAS kinase (PASK) is also a nutrient responsive protein kinase.
27	18344204	In cultured pancreatic beta-cells, PASK is activated by elevated glucose concentrations and is required for glucose-stimulated transcription of the insulin gene.
28	18344204	Interestingly, PGC-1 expression and AMPK and TOR activity were not affected in PASK deficient mice, suggesting PASK may exert its metabolic effects through a new mechanism.
29	22065581	Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.
30	22065581	PAS kinase (PASK) is a glucose-regulated protein kinase involved in the control of pancreatic islet hormone release and insulin sensitivity.
31	22065581	Mouse islets were therefore infected with adenoviruses expressing wild type or mutant PASK and the regulation of insulin secretion was examined.
32	22065581	PASK p.G1117E-infected islets displayed a 4-fold decrease in glucose-stimulated (16.7 versus 3 mM) insulin secretion, chiefly reflecting a 4.5-fold increase in insulin release at low glucose.
33	22065581	In summary, we have characterized a rare mutation (p.G1117E) in the PASK gene from a young-onset diabetes family, which modulates glucose-stimulated insulin secretion.
34	22065581	Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.
35	22065581	PAS kinase (PASK) is a glucose-regulated protein kinase involved in the control of pancreatic islet hormone release and insulin sensitivity.
36	22065581	Mouse islets were therefore infected with adenoviruses expressing wild type or mutant PASK and the regulation of insulin secretion was examined.
37	22065581	PASK p.G1117E-infected islets displayed a 4-fold decrease in glucose-stimulated (16.7 versus 3 mM) insulin secretion, chiefly reflecting a 4.5-fold increase in insulin release at low glucose.
38	22065581	In summary, we have characterized a rare mutation (p.G1117E) in the PASK gene from a young-onset diabetes family, which modulates glucose-stimulated insulin secretion.
39	22065581	Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.
40	22065581	PAS kinase (PASK) is a glucose-regulated protein kinase involved in the control of pancreatic islet hormone release and insulin sensitivity.
41	22065581	Mouse islets were therefore infected with adenoviruses expressing wild type or mutant PASK and the regulation of insulin secretion was examined.
42	22065581	PASK p.G1117E-infected islets displayed a 4-fold decrease in glucose-stimulated (16.7 versus 3 mM) insulin secretion, chiefly reflecting a 4.5-fold increase in insulin release at low glucose.
43	22065581	In summary, we have characterized a rare mutation (p.G1117E) in the PASK gene from a young-onset diabetes family, which modulates glucose-stimulated insulin secretion.
44	22065581	Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.
45	22065581	PAS kinase (PASK) is a glucose-regulated protein kinase involved in the control of pancreatic islet hormone release and insulin sensitivity.
46	22065581	Mouse islets were therefore infected with adenoviruses expressing wild type or mutant PASK and the regulation of insulin secretion was examined.
47	22065581	PASK p.G1117E-infected islets displayed a 4-fold decrease in glucose-stimulated (16.7 versus 3 mM) insulin secretion, chiefly reflecting a 4.5-fold increase in insulin release at low glucose.
48	22065581	In summary, we have characterized a rare mutation (p.G1117E) in the PASK gene from a young-onset diabetes family, which modulates glucose-stimulated insulin secretion.
49	22065581	Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.
50	22065581	PAS kinase (PASK) is a glucose-regulated protein kinase involved in the control of pancreatic islet hormone release and insulin sensitivity.
51	22065581	Mouse islets were therefore infected with adenoviruses expressing wild type or mutant PASK and the regulation of insulin secretion was examined.
52	22065581	PASK p.G1117E-infected islets displayed a 4-fold decrease in glucose-stimulated (16.7 versus 3 mM) insulin secretion, chiefly reflecting a 4.5-fold increase in insulin release at low glucose.
53	22065581	In summary, we have characterized a rare mutation (p.G1117E) in the PASK gene from a young-onset diabetes family, which modulates glucose-stimulated insulin secretion.