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Gene Information
Gene symbol: PCSK6
Gene name: proprotein convertase subtilisin/kexin type 6
HGNC ID: 8569
Synonyms: SPC4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | PCSK1 | 1 hits |
| 3 | PCSK2 | 1 hits |
| 4 | PCSK4 | 1 hits |
| 5 | PCSK5 | 1 hits |
| 6 | PCSK7 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8037679 | This fraction was not able to process an 35S-labelled insulin proreceptor variant substrate (where the Arg-1 of the tetrabasic cleavage site had been replaced by Ala-1), similarly to previous in vivo observations, suggesting that this endopeptidase activity has physiological relevance. |
| 2 | 8037679 | Immunoblotting detected furin and PACE4 proteins (both members of this family) to be present in the rat liver subcellular fraction containing insulin proreceptor processing activity. |
| 3 | 17012247 | Proteolysis occurring at basic residues is mediated by the basic amino acid-specific proprotein convertases, namely: PC1/3, PC2, furin, PACE4, PC4, PC5/6, and PC7. |
| 4 | 17012247 | In contrast, proteolysis at nonbasic residues is performed by the subtilisin/kexin-like isozyme-1 (SKI-1/S1P) and the newly identified neural apoptosis-regulated convertase-1 (PCSK9/NARC-1). |