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Gene Information
Gene symbol: PDE4B
Gene name: phosphodiesterase 4B, cAMP-specific
HGNC ID: 8781
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT2 | 1 hits |
| 2 | CD36 | 1 hits |
| 3 | INS | 1 hits |
| 4 | NSF | 1 hits |
| 5 | PDE3A | 1 hits |
| 6 | PDE3B | 1 hits |
| 7 | PDE4A | 1 hits |
| 8 | PDE4D | 1 hits |
| 9 | PDE8B | 1 hits |
| 10 | SCD | 1 hits |
| 11 | VAMP2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15546994 | To dissect and quantitate these two separate effects, we compared the skeletal muscle gene-expression profiles of muscle insulin receptor knockout (MIRKO) mice and their Lox controls in the basal, streptozotocin-induced diabetic, and insulin-treated diabetic states. |
| 2 | 15546994 | Pure deficiency of insulin action as present in the MIRKO mouse results in regulation of 130 genes, with down-regulation of NSF (N-ethylmaleimide-sensitive fusion protein) and VAMP-2 (vesicle-associated membrane protein 2), stearoyl CoA desaturase 1, and cAMP-specific phosphodiesterase 4B, as well as up-regulation of some signaling-related genes, such as Akt2, and the fatty-acid transporter CD36. |
| 3 | 17991719 | Diminished phosphodiesterase-8B potentiates biphasic insulin response to glucose. |
| 4 | 17991719 | Using RT-PCR and Western blot analyses, we identified PDE3A, PDE3B, PDE4B, PDE4D, and PDE8B in rat islets and in INS-1E cells and several possible splice variants of these PDEs. |
| 5 | 17991719 | Specific depletion of PDE3A with small interfering (si) RNA (siPDE3A) led to a small (67%) increase in the insulin response to glucose in INS-1E cells but not rat islets. siPDE3A had no effect on the glucagon-like peptide-1 (10 nmol/liter) potentiated insulin response in rat islets. |
| 6 | 17991719 | Depletion in PDE8B levels in rat islets using similar technology (siPDE8B) increased insulin response to glucose by 70%, the potentiation being of similar magnitude during the first and second phase insulin release. |
| 7 | 17991719 | The siPDE8B-potentiated insulin response was further increased by 23% when glucagon-like peptide-1 was included during the glucose stimulus. |
| 8 | 17991719 | We propose that PDE8B, an 3-isobutyl-1-methylxanthine-insensitive cAMP-specific phosphodiesterase, could prove a novel target for enhanced insulin response, affecting a specific pool of cAMP involved in the control of insulin granule trafficking and exocytosis. |