Ignet

Gene Information

Gene symbol: PDHA1

Gene name: pyruvate dehydrogenase (lipoamide) alpha 1

HGNC ID: 8806

Related Genes

#	Gene Symbol	Number of hits
1	INS	1 hits
2	PC	1 hits
3	PDHB	1 hits
4	PPM2C	1 hits

Related Sentences

#	PMID	Sentence
1	3053285	Effects of insulin on pyruvate dehydrogenase in circulating lymphocytes from normal and diabetic rats.
2	3053285	In vivo tests show that inactive PDH (PDHi) prevails in diabetic rats and active PDH (PDHa) in hyperinsulinemic rats; in treated with insulin diabetic rats the PDHa/PDHi ratio (1.7) is similar to that of normal rats (PDHa/PDHi ratio = 2). 3.
3	3527808	Effect of insulin on pyruvate dehydrogenase in a mixture of plasma membranes and mitochondria from normal and alloxan treated rat brains.
4	3527808	In a mixture of plasma membranes/mitochondria from normal rat brain, pyruvate dehydrogenase (PDH) is present in the active (PDHa) and the inactive (PDHi) form; the latter is converted into the former by preincubation with Ca2+ and Mg2+ and represents about 40% of total PDH (PDHt = PDHa + PDHi).
5	3527808	Incubation with increasing insulin concentrations activates PDHa and PDHt, the maximum being reached at 25 microU/ml insulin; inhibition appears with further insulin increase.
6	3527808	PDHa and PDHt activity reaches a maximum of stimulation at 25 microU/ml insulin; the activation is reduced at higher concentrations of insulin though no inhibition appears.
7	3527808	Effect of insulin on pyruvate dehydrogenase in a mixture of plasma membranes and mitochondria from normal and alloxan treated rat brains.
8	3527808	In a mixture of plasma membranes/mitochondria from normal rat brain, pyruvate dehydrogenase (PDH) is present in the active (PDHa) and the inactive (PDHi) form; the latter is converted into the former by preincubation with Ca2+ and Mg2+ and represents about 40% of total PDH (PDHt = PDHa + PDHi).
9	3527808	Incubation with increasing insulin concentrations activates PDHa and PDHt, the maximum being reached at 25 microU/ml insulin; inhibition appears with further insulin increase.
10	3527808	PDHa and PDHt activity reaches a maximum of stimulation at 25 microU/ml insulin; the activation is reduced at higher concentrations of insulin though no inhibition appears.
11	3527808	Effect of insulin on pyruvate dehydrogenase in a mixture of plasma membranes and mitochondria from normal and alloxan treated rat brains.
12	3527808	In a mixture of plasma membranes/mitochondria from normal rat brain, pyruvate dehydrogenase (PDH) is present in the active (PDHa) and the inactive (PDHi) form; the latter is converted into the former by preincubation with Ca2+ and Mg2+ and represents about 40% of total PDH (PDHt = PDHa + PDHi).
13	3527808	Incubation with increasing insulin concentrations activates PDHa and PDHt, the maximum being reached at 25 microU/ml insulin; inhibition appears with further insulin increase.
14	3527808	PDHa and PDHt activity reaches a maximum of stimulation at 25 microU/ml insulin; the activation is reduced at higher concentrations of insulin though no inhibition appears.
15	3902717	Effect of insulin on the pyruvate dehydrogenase complex in the rat brain.
16	3902717	PDHa and PDHt from alloxan rat brains are remarkably activated when assayed on samples obtained by combining and preincubating at 30 degrees C for 30 min a homogenate from fresh unfrozen brains of alloxan rats, with a similarly treated preparation from fresh unfrozen brains of normal or insulin rats.
17	7771776	A nuclear run-on assay showed that glucose caused increases in pyruvate carboxylase and pyruvate dehydrogenase E1 alpha subunit transcripts and decreases in branched chain ketoacid dehydrogenase E1 alpha transcripts in rat insulinoma (RINm5F) cells.
18	8492717	Insulin-induced activation of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats.
19	8492717	The pyruvate dehydrogenase (PDH) complex undergoes reversible phosphorylation catalyzed by a PDH kinase (inactivating) and a PDH phosphatase (activating).
20	8492717	In skeletal muscle, a decreased proportion of active PDH (PDHa) complex limits glucose oxidation in insulin-deficient states.
21	8492717	The time-course for reactivation of the PDH complex by insulin in skeletal muscle of diabetic rats is important to understanding the potential mode of the action of insulin in regulating glucose metabolism.
22	8492717	A single injection of insulin (1 U/kg) completely reversed the effects of alloxan-diabetes on PDHa activity within 1 hour.
23	8492717	The normalization of the effects of diabetes on PDHa activity by insulin was maintained for a minimum of 6 hours.
24	8492717	The increase in PDHa activity occurred before an insulin-induced decrease in plasma free fatty acids levels, demonstrating a dissociation between the antilipolytic effects of insulin and its ability to activate the PDH complex.
25	8492717	Therefore, acute (1 to 6 hours) insulin-mediated activation of the PDH complex does not result from a decrease in PDH kinase activity.
26	8492717	However, longer-term insulin therapy (1 U/kg body weight; twice daily) restored both PDHa and PDH kinase activities.
27	8492717	The results are consistent with the hypothesis that activation of the PDH complex immediately following insulin administration is not mediated by a decreased PDH kinase activity.
28	8492717	However, with daily insulin therapy in diabetes, activation of the PDH complex results from decreased PDH kinase activity.
29	8492717	Insulin-induced activation of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats.
30	8492717	The pyruvate dehydrogenase (PDH) complex undergoes reversible phosphorylation catalyzed by a PDH kinase (inactivating) and a PDH phosphatase (activating).
31	8492717	In skeletal muscle, a decreased proportion of active PDH (PDHa) complex limits glucose oxidation in insulin-deficient states.
32	8492717	The time-course for reactivation of the PDH complex by insulin in skeletal muscle of diabetic rats is important to understanding the potential mode of the action of insulin in regulating glucose metabolism.
33	8492717	A single injection of insulin (1 U/kg) completely reversed the effects of alloxan-diabetes on PDHa activity within 1 hour.
34	8492717	The normalization of the effects of diabetes on PDHa activity by insulin was maintained for a minimum of 6 hours.
35	8492717	The increase in PDHa activity occurred before an insulin-induced decrease in plasma free fatty acids levels, demonstrating a dissociation between the antilipolytic effects of insulin and its ability to activate the PDH complex.
36	8492717	Therefore, acute (1 to 6 hours) insulin-mediated activation of the PDH complex does not result from a decrease in PDH kinase activity.
37	8492717	However, longer-term insulin therapy (1 U/kg body weight; twice daily) restored both PDHa and PDH kinase activities.
38	8492717	The results are consistent with the hypothesis that activation of the PDH complex immediately following insulin administration is not mediated by a decreased PDH kinase activity.
39	8492717	However, with daily insulin therapy in diabetes, activation of the PDH complex results from decreased PDH kinase activity.
40	8492717	Insulin-induced activation of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats.
41	8492717	The pyruvate dehydrogenase (PDH) complex undergoes reversible phosphorylation catalyzed by a PDH kinase (inactivating) and a PDH phosphatase (activating).
42	8492717	In skeletal muscle, a decreased proportion of active PDH (PDHa) complex limits glucose oxidation in insulin-deficient states.
43	8492717	The time-course for reactivation of the PDH complex by insulin in skeletal muscle of diabetic rats is important to understanding the potential mode of the action of insulin in regulating glucose metabolism.
44	8492717	A single injection of insulin (1 U/kg) completely reversed the effects of alloxan-diabetes on PDHa activity within 1 hour.
45	8492717	The normalization of the effects of diabetes on PDHa activity by insulin was maintained for a minimum of 6 hours.
46	8492717	The increase in PDHa activity occurred before an insulin-induced decrease in plasma free fatty acids levels, demonstrating a dissociation between the antilipolytic effects of insulin and its ability to activate the PDH complex.
47	8492717	Therefore, acute (1 to 6 hours) insulin-mediated activation of the PDH complex does not result from a decrease in PDH kinase activity.
48	8492717	However, longer-term insulin therapy (1 U/kg body weight; twice daily) restored both PDHa and PDH kinase activities.
49	8492717	The results are consistent with the hypothesis that activation of the PDH complex immediately following insulin administration is not mediated by a decreased PDH kinase activity.
50	8492717	However, with daily insulin therapy in diabetes, activation of the PDH complex results from decreased PDH kinase activity.
51	8492717	Insulin-induced activation of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats.
52	8492717	The pyruvate dehydrogenase (PDH) complex undergoes reversible phosphorylation catalyzed by a PDH kinase (inactivating) and a PDH phosphatase (activating).
53	8492717	In skeletal muscle, a decreased proportion of active PDH (PDHa) complex limits glucose oxidation in insulin-deficient states.
54	8492717	The time-course for reactivation of the PDH complex by insulin in skeletal muscle of diabetic rats is important to understanding the potential mode of the action of insulin in regulating glucose metabolism.
55	8492717	A single injection of insulin (1 U/kg) completely reversed the effects of alloxan-diabetes on PDHa activity within 1 hour.
56	8492717	The normalization of the effects of diabetes on PDHa activity by insulin was maintained for a minimum of 6 hours.
57	8492717	The increase in PDHa activity occurred before an insulin-induced decrease in plasma free fatty acids levels, demonstrating a dissociation between the antilipolytic effects of insulin and its ability to activate the PDH complex.
58	8492717	Therefore, acute (1 to 6 hours) insulin-mediated activation of the PDH complex does not result from a decrease in PDH kinase activity.
59	8492717	However, longer-term insulin therapy (1 U/kg body weight; twice daily) restored both PDHa and PDH kinase activities.
60	8492717	The results are consistent with the hypothesis that activation of the PDH complex immediately following insulin administration is not mediated by a decreased PDH kinase activity.
61	8492717	However, with daily insulin therapy in diabetes, activation of the PDH complex results from decreased PDH kinase activity.
62	8492717	Insulin-induced activation of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats.
63	8492717	The pyruvate dehydrogenase (PDH) complex undergoes reversible phosphorylation catalyzed by a PDH kinase (inactivating) and a PDH phosphatase (activating).
64	8492717	In skeletal muscle, a decreased proportion of active PDH (PDHa) complex limits glucose oxidation in insulin-deficient states.
65	8492717	The time-course for reactivation of the PDH complex by insulin in skeletal muscle of diabetic rats is important to understanding the potential mode of the action of insulin in regulating glucose metabolism.
66	8492717	A single injection of insulin (1 U/kg) completely reversed the effects of alloxan-diabetes on PDHa activity within 1 hour.
67	8492717	The normalization of the effects of diabetes on PDHa activity by insulin was maintained for a minimum of 6 hours.
68	8492717	The increase in PDHa activity occurred before an insulin-induced decrease in plasma free fatty acids levels, demonstrating a dissociation between the antilipolytic effects of insulin and its ability to activate the PDH complex.
69	8492717	Therefore, acute (1 to 6 hours) insulin-mediated activation of the PDH complex does not result from a decrease in PDH kinase activity.
70	8492717	However, longer-term insulin therapy (1 U/kg body weight; twice daily) restored both PDHa and PDH kinase activities.
71	8492717	The results are consistent with the hypothesis that activation of the PDH complex immediately following insulin administration is not mediated by a decreased PDH kinase activity.
72	8492717	However, with daily insulin therapy in diabetes, activation of the PDH complex results from decreased PDH kinase activity.
73	9344771	In this study, we present a reliable and simple method for assaying both the active and total forms of PDH (PDHa and PDHt respectively) in cardiac tissue, and have compared the effects of pressure overload hypertrophy and diabetes on PDH activity.