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Gene Information
Gene symbol: PENK
Gene name: proenkephalin
HGNC ID: 8831
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | POMC | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10233022 | STZ-induced diabetes decreases and insulin normalizes POMC mRNA in arcuate nucleus and pituitary in rats. |
| 2 | 10233022 | Proopiomelanocortin (POMC) mRNA in arcuate nucleus (Arc) and pituitary decreased in diabetes and normalized after insulin treatment. |
| 3 | 10233022 | Prodynorphin (proDyn) mRNA increased in diabetes and normalized in the pituitary after insulin but not in the Arc. |
| 4 | 10233022 | Diabetes did not alter proenkephalin (proEnk) expression in the Arc or pituitary, nor dynorphin A1-17 or beta-endorphin in paraventricular nucleus (PVN). alpha-Melanocyte-stimulating hormone (alpha-MSH) peptide levels were decreased in the PVN and normalized following insulin treatment. |
| 5 | 10233022 | Diabetes increased Arc neuropeptide Y mRNA, and insulin suppressed this increase. |
| 6 | 10233022 | In experiment 2, insulin (2.5 IU/kg sc) daily for 1 wk in normal rats increased Arc POMC mRNA, but not proDyn and proEnk mRNA. |
| 7 | 10233022 | Also, insulin may influence Arc and pituitary POMC activity in neurons that regulate energy metabolism. |