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Gene Information
Gene symbol: PHEX
Gene name: phosphate regulating endopeptidase homolog, X-linked
HGNC ID: 8918
Synonyms: PEX, HPDR1, HYP1, XLH
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AVP | 1 hits |
| 2 | BGLAP | 1 hits |
| 3 | COL1A2 | 1 hits |
| 4 | DMP1 | 1 hits |
| 5 | IBSP | 1 hits |
| 6 | IGF1 | 1 hits |
| 7 | INS | 1 hits |
| 8 | MMP9 | 1 hits |
| 9 | RUNX2 | 1 hits |
| 10 | SP7 | 1 hits |
| 11 | VDR | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11064151 | Phex cDNA cloning from rat bone and studies on phex mRNA expression: tissue-specificity, age-dependency, and regulation by insulin-like growth factor (IGF) I in vivo. |
| 2 | 16753019 | Vitamin D-resistant rickets and type 1 diabetes in a child with compound heterozygous mutations of the vitamin D receptor (L263R and R391S): dissociated responses of the CYP-24 and rel-B promoters to 1,25-dihydroxyvitamin D3. |
| 3 | 17071612 | Clinically apparent hereditary vitamin D-resistant rickets (HVDRR) usually results from a loss of function mutation in the vitamin D receptor (VDR). |
| 4 | 17071612 | Hormone resistance resulted from constitutive overexpression of heterogeneous nuclear ribonucleoprotein (hnRNP) that competed with a normally functioning VDR-retinoid X receptor (RXR) dimer for binding to the vitamin D response element (VDRE). |
| 5 | 17071612 | By contrast, transient expression of an hnRNP C1/C2 small interfering RNA increased VDR transactivation by 39% (p < 0.005). |
| 6 | 17071612 | Chromatin immunoprecipitation of nucleoproteins bound to the transcriptionally active 1,25-dihydroxy vitamin D-driven CYP24 promoter revealed the presence of REBiP in vitamin D-responsive human cells and indicated that the normal pattern of 1,25-dihydroxy vitamin D-initiated cyclical movement of the VDR on and off the VDRE is legislated by competitive, reciprocal occupancy of the VDRE by hnRNP C1/C2. |
| 7 | 17071612 | The temporal and reciprocal pattern of VDR and hnRNPC1/C2 interaction with the VDRE was lost in HVDRR cells overexpressing the hnRNP C1/C2 REBiP. |
| 8 | 18162513 | Runt-related transcription factor 2 (RUNX2), and several RUNX2 target genes, including matrix metalloproteinase-9, Akp2, integrin binding sialoprotein, Dmp1, Col1a2, Phex, Vdr, osteocalcin, and osterix, were all significantly down-regulated in the insulin-deficient, hyperglycemic diabetic animals; however, insulin treatment of diabetic animals significantly restored their expression. |
| 9 | 18162513 | Expression of bone morphogenic protein-2, transcriptional coactivator with PDZ-binding motif, and TWIST2, all important regulators of RUNX2, were not impacted by the diabetic condition, suggesting that the defect in osteogenesis resides at the level of RUNX2 expression and its activity. |
| 10 | 22145469 | Idiopathic Fanconi's syndrome with nephrogenic diabetes insipidus in a child who presented as vitamin D resistant rickets--a case report and review of literature. |