- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: PHOX2A
Gene name: paired-like homeobox 2a
HGNC ID: 691
Synonyms: PMX2A, CFEOM2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ARX | 1 hits |
| 2 | HDAC1 | 1 hits |
| 3 | INPPL1 | 1 hits |
| 4 | INS | 1 hits |
| 5 | NKX2-2 | 1 hits |
| 6 | TLE3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15964236 | The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2. |
| 2 | 15964236 | The SH2 domain containing inositol polyphosphate 5-phosphatase-2 (SHIP2) hydrolyzes phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) generating phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). |
| 3 | 15964236 | Overexpression of SHIP2 inhibits insulin-stimulated phosphoinositide 3-kinase (PI3K) dependent signaling events. |
| 4 | 15964236 | SHIP2 knockout mice were originally reported to show lethal neonatal hypoglycemia resulting from insulin hypersensitivity, but in addition to inactivating the SHIP2 gene, the Phox2a gene was also inadvertently deleted. |
| 5 | 15964236 | Another SHIP2 knockout mouse has now been generated which inactivates the SHIP2 gene but leaves Phox2a intact. |
| 6 | 15964236 | The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2. |
| 7 | 15964236 | The SH2 domain containing inositol polyphosphate 5-phosphatase-2 (SHIP2) hydrolyzes phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) generating phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). |
| 8 | 15964236 | Overexpression of SHIP2 inhibits insulin-stimulated phosphoinositide 3-kinase (PI3K) dependent signaling events. |
| 9 | 15964236 | SHIP2 knockout mice were originally reported to show lethal neonatal hypoglycemia resulting from insulin hypersensitivity, but in addition to inactivating the SHIP2 gene, the Phox2a gene was also inadvertently deleted. |
| 10 | 15964236 | Another SHIP2 knockout mouse has now been generated which inactivates the SHIP2 gene but leaves Phox2a intact. |
| 11 | 22056672 | In this study, we demonstrate that Nkx2.2 is part of a large repression complex in pancreatic β cells that includes DNMT3a, Grg3, and HDAC1. |
| 12 | 22056672 | Mutation of the endogenous Nkx2.2 tinman (TN) domain in mice abolishes the interaction between Nkx2.2 and Grg3 and disrupts β-cell specification. |
| 13 | 22056672 | Furthermore, we demonstrate that Nkx2.2 preferentially recruits Grg3 and HDAC1 to the methylated Aristaless homeobox gene (Arx) promoter in β cells. |
| 14 | 22056672 | The Nkx2.2 TN mutation results in ectopic expression of Arx in β cells, causing β-to-α-cell transdifferentiation. |
| 15 | 22056672 | Notably, subsequent removal of Arx in the β cells of Nkx2.2(TNmut/TNmut) mutant mice reverts the β-to-α-cell conversion, indicating that the repressor activities of Nkx2.2 on the methylated Arx promoter in β cells are the primary regulatory events required for maintaining β-cell identity. |