Ignet

Gene Information

Gene symbol: PIK3C3

Gene name: phosphatidylinositol 3-kinase, catalytic subunit type 3

HGNC ID: 8974

Synonyms: Vps34

Related Genes

#	Gene Symbol	Number of hits
1	ABL1	1 hits
2	BECN1	1 hits
3	CLDN5	1 hits
4	PI3	1 hits
5	PIK3CA	1 hits
6	PIK3CG	1 hits
7	PIK3R4	1 hits
8	STAT3	1 hits

Related Sentences

#	PMID	Sentence
1	16111945	Here we show that BEC-1, the C. elegans ortholog of the yeast and mammalian autophagy proteins Atg6/Vps30 and Beclin 1, is essential for development.
2	16111945	We demonstrate that BEC-1 is necessary for the function of the class III PI3 kinase LET-512/Vps34, an essential protein required for autophagy, membrane trafficking, and endocytosis.
3	16111945	Furthermore, BEC-1 forms a complex with the antiapoptotic protein CED-9/Bcl-2, and its depletion triggers CED-3/Caspase-dependent PCD.
4	16753575	Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.
5	16753575	Recent studies have revealed that ribosomal protein S6 kinase 1, S6K1, an effector of mTOR, is sensitive to both insulin and nutrients, including amino acids.
6	16753575	Although S6K1 is an effector of growth, recent reports show that amino acids also negatively affect insulin signaling through mTOR/S6K1 phosphorylation of IRS1.
7	16753575	Moreover, rather than signaling through the class 1 PI3K pathway, amino acids appear to mediate mTOR activation through class 3 PI3K, or hVps34.
8	16753575	Consistent with this, infusion of amino acids into humans leads to S6K1 activation, inhibition of insulin-induced class 1 PI3K activation, and insulin resistance.
9	16753575	Thus, S6K1 may mediate deleterious effects, like insulin resistance, and potentially type 2 diabetes in the face of nutrient excess.
10	18673414	Mutations in the arginine vasopressin (AVP)-neurophysin II (NP-II) gene that affect the folding and transport of the prohormone result in loss of secretion of the anti-diuretic hormone AVP from pituitary nerve terminals and cause autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI).
11	18673414	This was shown by the expression of a Vps34 dominant negative, which down-regulates the PI3k class III-dependent signalling needed for autophagosome (APH) formation, by genetic silencing as a result of RNA interference (RNAi) of Lamp2, a protein indispensable for the fusion of APHs with lysosomes, and by RNAi silencing of the lysosomal protease CD.
12	22745922	Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway.
13	22745922	This was due to inhibition of macroautophagy via an mTORC1-independent but STAT3-dependent reduction in Vps34 protein levels and decreased Vps34/p150/Beclin1/Atg14 complex 1.
14	22745922	In parallel, Y705-STAT3 phosphorylation increased with decreased Vps34 protein levels.
15	22745922	Moreover, fed/starved regulation of Y705-STAT3 phosphorylation and Vps34 protein levels was prevented in skeletal muscle of Fyn null mice.
16	22745922	These data demonstrate a Fyn/STAT3/Vps34 pathway that is responsible for fiber-type-specific regulation of macroautophagy and skeletal muscle atrophy.
17	22745922	Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway.
18	22745922	This was due to inhibition of macroautophagy via an mTORC1-independent but STAT3-dependent reduction in Vps34 protein levels and decreased Vps34/p150/Beclin1/Atg14 complex 1.
19	22745922	In parallel, Y705-STAT3 phosphorylation increased with decreased Vps34 protein levels.
20	22745922	Moreover, fed/starved regulation of Y705-STAT3 phosphorylation and Vps34 protein levels was prevented in skeletal muscle of Fyn null mice.
21	22745922	These data demonstrate a Fyn/STAT3/Vps34 pathway that is responsible for fiber-type-specific regulation of macroautophagy and skeletal muscle atrophy.
22	22745922	Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway.
23	22745922	This was due to inhibition of macroautophagy via an mTORC1-independent but STAT3-dependent reduction in Vps34 protein levels and decreased Vps34/p150/Beclin1/Atg14 complex 1.
24	22745922	In parallel, Y705-STAT3 phosphorylation increased with decreased Vps34 protein levels.
25	22745922	Moreover, fed/starved regulation of Y705-STAT3 phosphorylation and Vps34 protein levels was prevented in skeletal muscle of Fyn null mice.
26	22745922	These data demonstrate a Fyn/STAT3/Vps34 pathway that is responsible for fiber-type-specific regulation of macroautophagy and skeletal muscle atrophy.
27	22745922	Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway.
28	22745922	This was due to inhibition of macroautophagy via an mTORC1-independent but STAT3-dependent reduction in Vps34 protein levels and decreased Vps34/p150/Beclin1/Atg14 complex 1.
29	22745922	In parallel, Y705-STAT3 phosphorylation increased with decreased Vps34 protein levels.
30	22745922	Moreover, fed/starved regulation of Y705-STAT3 phosphorylation and Vps34 protein levels was prevented in skeletal muscle of Fyn null mice.
31	22745922	These data demonstrate a Fyn/STAT3/Vps34 pathway that is responsible for fiber-type-specific regulation of macroautophagy and skeletal muscle atrophy.
32	22745922	Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway.
33	22745922	This was due to inhibition of macroautophagy via an mTORC1-independent but STAT3-dependent reduction in Vps34 protein levels and decreased Vps34/p150/Beclin1/Atg14 complex 1.
34	22745922	In parallel, Y705-STAT3 phosphorylation increased with decreased Vps34 protein levels.
35	22745922	Moreover, fed/starved regulation of Y705-STAT3 phosphorylation and Vps34 protein levels was prevented in skeletal muscle of Fyn null mice.
36	22745922	These data demonstrate a Fyn/STAT3/Vps34 pathway that is responsible for fiber-type-specific regulation of macroautophagy and skeletal muscle atrophy.
37	22843415	Protein expression of the autophagy markers LC3/Atg8 and Atg7 exhibited a marked decline in aged islets.
38	22843415	However, protein expression of beclin-1/Atg6, which plays an important role in the induction and formation of the pre-autophagosome structure by associating with a multimeric complex of autophagy regulatory proteins (Atg14, Vps34/class 3 PI3 kinase, and Vps15), was most prominent in the islets of adult rats, and was higher in 24-month-old islets than in 4-month-old islets.
39	23551104	Class III PI3K Vps34: essential roles in autophagy, endocytosis, and heart and liver function.
40	23551104	One family member, Vps34, is of particular interest because it is the only PI3-kinase identified in yeast and it has been evolutionarily conserved through mammals.
41	23551104	Class III PI3K Vps34: essential roles in autophagy, endocytosis, and heart and liver function.
42	23551104	One family member, Vps34, is of particular interest because it is the only PI3-kinase identified in yeast and it has been evolutionarily conserved through mammals.