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Gene Information
Gene symbol: PIK3R4
Gene name: phosphoinositide-3-kinase, regulatory subunit 4
HGNC ID: 8982
Synonyms: VPS15, p150
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BBS4 | 1 hits |
| 2 | BECN1 | 1 hits |
| 3 | DCTN1 | 1 hits |
| 4 | PCM1 | 1 hits |
| 5 | PI3 | 1 hits |
| 6 | PIK3C3 | 1 hits |
| 7 | PIK3CG | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15107855 | Here we show that BBS4 localizes to the centriolar satellites of centrosomes and basal bodies of primary cilia, where it functions as an adaptor of the p150(glued) subunit of the dynein transport machinery to recruit PCM1 (pericentriolar material 1 protein) and its associated cargo to the satellites. |
| 2 | 15107855 | Silencing of BBS4 induces PCM1 mislocalization and concomitant deanchoring of centrosomal microtubules, arrest in cell division and apoptotic cell death. |
| 3 | 15107855 | Expression of two truncated forms of BBS4 that are similar to those found in some individuals with BBS had a similar effect on PCM1 and microtubules. |
| 4 | 22843415 | Protein expression of the autophagy markers LC3/Atg8 and Atg7 exhibited a marked decline in aged islets. |
| 5 | 22843415 | However, protein expression of beclin-1/Atg6, which plays an important role in the induction and formation of the pre-autophagosome structure by associating with a multimeric complex of autophagy regulatory proteins (Atg14, Vps34/class 3 PI3 kinase, and Vps15), was most prominent in the islets of adult rats, and was higher in 24-month-old islets than in 4-month-old islets. |