Ignet

Gene Information

Gene symbol: PKNOX1

Gene name: PBX/knotted 1 homeobox 1

HGNC ID: 9022

Synonyms: PREP1

Related Genes

#	Gene Symbol	Number of hits
1	INS	1 hits
2	MYBBP1A	1 hits

Related Sentences

#	PMID	Sentence
1	18644868	Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
2	18644868	Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance.
3	18644868	Instead, in Prep1(i/i) muscle, we find normal Pbx1 but reduced levels of the recently identified novel Prep1 interactor p160.
4	18644868	Consistent with this reduction, we find a muscle-selective increase in mRNA and protein levels of PGC-1alpha, accompanied by enhanced expression of the GLUT4 transporter, responsible for insulin-stimulated glucose uptake in muscle.
5	18644868	Indeed, using L6 skeletal muscle cells, we induced the opposite effects by overexpressing Prep1 or p160, but not Pbx1.
6	18644868	In vivo skeletal muscle delivery of p160 cDNA in Prep1(i/i) mice also reverses the molecular phenotype.
7	18644868	Finally, we show that Prep1 controls the stability of the p160 protein.
8	18644868	We conclude that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway.
9	18644868	Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
10	18644868	Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance.
11	18644868	Instead, in Prep1(i/i) muscle, we find normal Pbx1 but reduced levels of the recently identified novel Prep1 interactor p160.
12	18644868	Consistent with this reduction, we find a muscle-selective increase in mRNA and protein levels of PGC-1alpha, accompanied by enhanced expression of the GLUT4 transporter, responsible for insulin-stimulated glucose uptake in muscle.
13	18644868	Indeed, using L6 skeletal muscle cells, we induced the opposite effects by overexpressing Prep1 or p160, but not Pbx1.
14	18644868	In vivo skeletal muscle delivery of p160 cDNA in Prep1(i/i) mice also reverses the molecular phenotype.
15	18644868	Finally, we show that Prep1 controls the stability of the p160 protein.
16	18644868	We conclude that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway.
17	18644868	Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
18	18644868	Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance.
19	18644868	Instead, in Prep1(i/i) muscle, we find normal Pbx1 but reduced levels of the recently identified novel Prep1 interactor p160.
20	18644868	Consistent with this reduction, we find a muscle-selective increase in mRNA and protein levels of PGC-1alpha, accompanied by enhanced expression of the GLUT4 transporter, responsible for insulin-stimulated glucose uptake in muscle.
21	18644868	Indeed, using L6 skeletal muscle cells, we induced the opposite effects by overexpressing Prep1 or p160, but not Pbx1.
22	18644868	In vivo skeletal muscle delivery of p160 cDNA in Prep1(i/i) mice also reverses the molecular phenotype.
23	18644868	Finally, we show that Prep1 controls the stability of the p160 protein.
24	18644868	We conclude that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway.
25	18644868	Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
26	18644868	Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance.
27	18644868	Instead, in Prep1(i/i) muscle, we find normal Pbx1 but reduced levels of the recently identified novel Prep1 interactor p160.
28	18644868	Consistent with this reduction, we find a muscle-selective increase in mRNA and protein levels of PGC-1alpha, accompanied by enhanced expression of the GLUT4 transporter, responsible for insulin-stimulated glucose uptake in muscle.
29	18644868	Indeed, using L6 skeletal muscle cells, we induced the opposite effects by overexpressing Prep1 or p160, but not Pbx1.
30	18644868	In vivo skeletal muscle delivery of p160 cDNA in Prep1(i/i) mice also reverses the molecular phenotype.
31	18644868	Finally, we show that Prep1 controls the stability of the p160 protein.
32	18644868	We conclude that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway.
33	18644868	Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
34	18644868	Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance.
35	18644868	Instead, in Prep1(i/i) muscle, we find normal Pbx1 but reduced levels of the recently identified novel Prep1 interactor p160.
36	18644868	Consistent with this reduction, we find a muscle-selective increase in mRNA and protein levels of PGC-1alpha, accompanied by enhanced expression of the GLUT4 transporter, responsible for insulin-stimulated glucose uptake in muscle.
37	18644868	Indeed, using L6 skeletal muscle cells, we induced the opposite effects by overexpressing Prep1 or p160, but not Pbx1.
38	18644868	In vivo skeletal muscle delivery of p160 cDNA in Prep1(i/i) mice also reverses the molecular phenotype.
39	18644868	Finally, we show that Prep1 controls the stability of the p160 protein.
40	18644868	We conclude that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway.
41	18644868	Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
42	18644868	Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance.
43	18644868	Instead, in Prep1(i/i) muscle, we find normal Pbx1 but reduced levels of the recently identified novel Prep1 interactor p160.
44	18644868	Consistent with this reduction, we find a muscle-selective increase in mRNA and protein levels of PGC-1alpha, accompanied by enhanced expression of the GLUT4 transporter, responsible for insulin-stimulated glucose uptake in muscle.
45	18644868	Indeed, using L6 skeletal muscle cells, we induced the opposite effects by overexpressing Prep1 or p160, but not Pbx1.
46	18644868	In vivo skeletal muscle delivery of p160 cDNA in Prep1(i/i) mice also reverses the molecular phenotype.
47	18644868	Finally, we show that Prep1 controls the stability of the p160 protein.
48	18644868	We conclude that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway.
49	18644868	Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
50	18644868	Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance.
51	18644868	Instead, in Prep1(i/i) muscle, we find normal Pbx1 but reduced levels of the recently identified novel Prep1 interactor p160.
52	18644868	Consistent with this reduction, we find a muscle-selective increase in mRNA and protein levels of PGC-1alpha, accompanied by enhanced expression of the GLUT4 transporter, responsible for insulin-stimulated glucose uptake in muscle.
53	18644868	Indeed, using L6 skeletal muscle cells, we induced the opposite effects by overexpressing Prep1 or p160, but not Pbx1.
54	18644868	In vivo skeletal muscle delivery of p160 cDNA in Prep1(i/i) mice also reverses the molecular phenotype.
55	18644868	Finally, we show that Prep1 controls the stability of the p160 protein.
56	18644868	We conclude that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway.