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Gene Information
Gene symbol: PLK4
Gene name: polo-like kinase 4
HGNC ID: 11397
Synonyms: Sak
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | SASS6 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21497766 | Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. |
| 2 | 21497766 | In worms, flies, and humans, centriole assembly is dependent upon a key regulatory kinase (ZYG-1/Sak/Plk4) and its downstream effectors SAS-5 and SAS-6. |
| 3 | 21497766 | We find that the PP2A catalytic subunit LET-92, the scaffolding subunit PAA-1, and the B55 regulatory subunit SUR-6 function together to positively regulate centriole assembly. |
| 4 | 21497766 | In PP2A-SUR-6-depleted embryos, the levels of ZYG-1 and SAS-5 are reduced and the ZYG-1- and SAS-5-dependent recruitment of SAS-6 to the nascent centriole fails. |