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PMID |
Sentence |
1 |
123780
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It is concluded that elevated glomerular lysine hydroxylase activity accompanies the increased glomerular collagen synthesis found in streptozotocin diabetes, and that chronic hyperglycemia may be implicated in these changes.
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2 |
186346
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When the changes were expressed as total enzyme activities per two kidneys, again no changes were found in any enzyme activity at four weeks, but at 12 weeks significant increases were found in all four enzyme activities, namely prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase, and collagen glucosyltransferase.
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3 |
189835
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Effect of diabetes and insulin on rat renal glomerular protocollagen hydroxylase activities.
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4 |
189835
|
The effect of diabetes and insulin on the activities of both prolyl hydroxylase (trivial name; proline,2-oxoglutarate dioxygenase, EC 1.14.11.2) and lysyl hydroxylase (trivial name; lysine,2-oxoglutarate dioxygenase, EC 1.14.11.4) in isolated rat renal glomeruli was determined.
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5 |
189835
|
Administration of insulin to streptozotocin-injected animals completely restored glomerular lysyl hydroxylase to normal levels.
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6 |
189835
|
The results suggest that the specific elevation of lysyl hydroxylase relates to the biochemical changes contributory to diabetic nephropathy, and that insulin may reverse this process.
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7 |
189835
|
Effect of diabetes and insulin on rat renal glomerular protocollagen hydroxylase activities.
|
8 |
189835
|
The effect of diabetes and insulin on the activities of both prolyl hydroxylase (trivial name; proline,2-oxoglutarate dioxygenase, EC 1.14.11.2) and lysyl hydroxylase (trivial name; lysine,2-oxoglutarate dioxygenase, EC 1.14.11.4) in isolated rat renal glomeruli was determined.
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9 |
189835
|
Administration of insulin to streptozotocin-injected animals completely restored glomerular lysyl hydroxylase to normal levels.
|
10 |
189835
|
The results suggest that the specific elevation of lysyl hydroxylase relates to the biochemical changes contributory to diabetic nephropathy, and that insulin may reverse this process.
|
11 |
189835
|
Effect of diabetes and insulin on rat renal glomerular protocollagen hydroxylase activities.
|
12 |
189835
|
The effect of diabetes and insulin on the activities of both prolyl hydroxylase (trivial name; proline,2-oxoglutarate dioxygenase, EC 1.14.11.2) and lysyl hydroxylase (trivial name; lysine,2-oxoglutarate dioxygenase, EC 1.14.11.4) in isolated rat renal glomeruli was determined.
|
13 |
189835
|
Administration of insulin to streptozotocin-injected animals completely restored glomerular lysyl hydroxylase to normal levels.
|
14 |
189835
|
The results suggest that the specific elevation of lysyl hydroxylase relates to the biochemical changes contributory to diabetic nephropathy, and that insulin may reverse this process.
|
15 |
23785354
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Collagen cross-links can be divided into lysyl hydroxylase and lysyl oxidase-mediated enzymatic immature divalent cross-links, mature trivalent cross-links, and glycation- or oxidation-induced non-enzymatic cross-links (Advanced Glycation End-products: AGEs) such as pentosidine.
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