Ignet
Search (e.g., vaccine, IFNG): Help
About
Home
Introduction
Statistics
Programs
Dignet
Gene
GenePair
BioSummarAI
Help & Docs
Documents
Help
FAQs
Links
Acknowledge
Disclaimer
Contact Us
UM Logo

UMMS Logo

UMMS Logo

Gene Information

Gene symbol: PLOD1

Gene name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

HGNC ID: 9081

Synonyms: LH1

Related Genes

# Gene Symbol Number of hits
1 B3GALTL 1 hits
2 COL1A1 1 hits
3 INS 1 hits
4 LOX 1 hits

Related Sentences

# PMID Sentence
1 123780 It is concluded that elevated glomerular lysine hydroxylase activity accompanies the increased glomerular collagen synthesis found in streptozotocin diabetes, and that chronic hyperglycemia may be implicated in these changes.
2 186346 When the changes were expressed as total enzyme activities per two kidneys, again no changes were found in any enzyme activity at four weeks, but at 12 weeks significant increases were found in all four enzyme activities, namely prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase, and collagen glucosyltransferase.
3 189835 Effect of diabetes and insulin on rat renal glomerular protocollagen hydroxylase activities.
4 189835 The effect of diabetes and insulin on the activities of both prolyl hydroxylase (trivial name; proline,2-oxoglutarate dioxygenase, EC 1.14.11.2) and lysyl hydroxylase (trivial name; lysine,2-oxoglutarate dioxygenase, EC 1.14.11.4) in isolated rat renal glomeruli was determined.
5 189835 Administration of insulin to streptozotocin-injected animals completely restored glomerular lysyl hydroxylase to normal levels.
6 189835 The results suggest that the specific elevation of lysyl hydroxylase relates to the biochemical changes contributory to diabetic nephropathy, and that insulin may reverse this process.
7 189835 Effect of diabetes and insulin on rat renal glomerular protocollagen hydroxylase activities.
8 189835 The effect of diabetes and insulin on the activities of both prolyl hydroxylase (trivial name; proline,2-oxoglutarate dioxygenase, EC 1.14.11.2) and lysyl hydroxylase (trivial name; lysine,2-oxoglutarate dioxygenase, EC 1.14.11.4) in isolated rat renal glomeruli was determined.
9 189835 Administration of insulin to streptozotocin-injected animals completely restored glomerular lysyl hydroxylase to normal levels.
10 189835 The results suggest that the specific elevation of lysyl hydroxylase relates to the biochemical changes contributory to diabetic nephropathy, and that insulin may reverse this process.
11 189835 Effect of diabetes and insulin on rat renal glomerular protocollagen hydroxylase activities.
12 189835 The effect of diabetes and insulin on the activities of both prolyl hydroxylase (trivial name; proline,2-oxoglutarate dioxygenase, EC 1.14.11.2) and lysyl hydroxylase (trivial name; lysine,2-oxoglutarate dioxygenase, EC 1.14.11.4) in isolated rat renal glomeruli was determined.
13 189835 Administration of insulin to streptozotocin-injected animals completely restored glomerular lysyl hydroxylase to normal levels.
14 189835 The results suggest that the specific elevation of lysyl hydroxylase relates to the biochemical changes contributory to diabetic nephropathy, and that insulin may reverse this process.
15 23785354 Collagen cross-links can be divided into lysyl hydroxylase and lysyl oxidase-mediated enzymatic immature divalent cross-links, mature trivalent cross-links, and glycation- or oxidation-induced non-enzymatic cross-links (Advanced Glycation End-products: AGEs) such as pentosidine.