Ignet

Gene Information

Gene symbol: POLE3

Gene name: polymerase (DNA directed), epsilon 3, accessory subunit

HGNC ID: 13546

Synonyms: CHRAC17, Ybl1, p17, CHARAC17

Related Genes

#	Gene Symbol	Number of hits
1	C2orf28	1 hits
2	CDK2AP2	1 hits
3	CDKN2A	1 hits
4	EXOSC1	1 hits
5	GAD1	1 hits
6	GAD2	1 hits
7	IDDM2	1 hits
8	PRL	1 hits

Related Sentences

#	PMID	Sentence
1	2775272	Recently we identified five novel peptides of Mr 13,000 to 18,000 (designated P13, P14, P16, P17, and P18 according to approximate Mr) in the anterior pituitary gland of rat and man that appeared related to GH and PRL in regulation and structure.
2	2775272	We have now raised polyclonal antibodies in the rabbit to four of these peptides--P13, P14, P17 and P18--isolated from rat anterior pituitary; the rabbit injected with P16 did not produce antibodies.
3	2775272	Antiserum to P17, in addition, crossreacted very strongly with rat PRL, while P18 antiserum crossreacted not only with human GH but also with its 20K and cleaved variants.
4	2775272	Recently we identified five novel peptides of Mr 13,000 to 18,000 (designated P13, P14, P16, P17, and P18 according to approximate Mr) in the anterior pituitary gland of rat and man that appeared related to GH and PRL in regulation and structure.
5	2775272	We have now raised polyclonal antibodies in the rabbit to four of these peptides--P13, P14, P17 and P18--isolated from rat anterior pituitary; the rabbit injected with P16 did not produce antibodies.
6	2775272	Antiserum to P17, in addition, crossreacted very strongly with rat PRL, while P18 antiserum crossreacted not only with human GH but also with its 20K and cleaved variants.
7	3178830	Electrophoretic analysis of murine anterior pituitary extract revealed five major proteins of Mr 13,000-18,000 (designated P13, P14, P16, P17, and P18 according to Mr), three of which, P16, P17, and P18, were markedly influenced by estradiol benzoate and perphenazine in a manner similar to that of growth hormone, and two, P13 and P14, to that of prolactin.
8	3178830	Tyrosine peptide mapping showed partial resemblance of fingerprints for P16 and P17 (and possibly P18) to those for growth hormone, and of P13 and P14 to those for prolactin.
9	3178830	Both P14 and P18 bound to Concanavalin A.
10	3178830	The concentrations of P13 and P14 in pituitaries from lactating rats and in a prolactinoma were distinctly higher than normal.
11	3178830	These results suggest that P16, P17 and P18 are growth hormone- and P13 and P14 prolactin-related secretory proteins of the pituitary.
12	3178830	Electrophoretic analysis of murine anterior pituitary extract revealed five major proteins of Mr 13,000-18,000 (designated P13, P14, P16, P17, and P18 according to Mr), three of which, P16, P17, and P18, were markedly influenced by estradiol benzoate and perphenazine in a manner similar to that of growth hormone, and two, P13 and P14, to that of prolactin.
13	3178830	Tyrosine peptide mapping showed partial resemblance of fingerprints for P16 and P17 (and possibly P18) to those for growth hormone, and of P13 and P14 to those for prolactin.
14	3178830	Both P14 and P18 bound to Concanavalin A.
15	3178830	The concentrations of P13 and P14 in pituitaries from lactating rats and in a prolactinoma were distinctly higher than normal.
16	3178830	These results suggest that P16, P17 and P18 are growth hormone- and P13 and P14 prolactin-related secretory proteins of the pituitary.
17	3178830	Electrophoretic analysis of murine anterior pituitary extract revealed five major proteins of Mr 13,000-18,000 (designated P13, P14, P16, P17, and P18 according to Mr), three of which, P16, P17, and P18, were markedly influenced by estradiol benzoate and perphenazine in a manner similar to that of growth hormone, and two, P13 and P14, to that of prolactin.
18	3178830	Tyrosine peptide mapping showed partial resemblance of fingerprints for P16 and P17 (and possibly P18) to those for growth hormone, and of P13 and P14 to those for prolactin.
19	3178830	Both P14 and P18 bound to Concanavalin A.
20	3178830	The concentrations of P13 and P14 in pituitaries from lactating rats and in a prolactinoma were distinctly higher than normal.
21	3178830	These results suggest that P16, P17 and P18 are growth hormone- and P13 and P14 prolactin-related secretory proteins of the pituitary.
22	9084973	GAD65 is one of the major autoantigens associated with insulin-dependent diabetes mellitus (IDDM).
23	9084973	The two peptides p17 and p18 of GAD65 that share sequence similarity with coxsackie virus (amino acid sequence identity: PEVKEK) appeared to be the major determinants of GAD65 recognized preferably by T cells from new-onset IDDM patients and their first degree relatives.
24	9084973	In contrast, in our study unrelated control subjects frequently recognized the two GAD peptides (55%, 16/29), similar to first degree relatives (41%, 12/29) and IDDM patients post-onset (68%, 15/22).
25	9084973	Moreover, this study demonstrated a positive correlation of T-cell proliferation to GAD p17 (amino acid 247-266) and p18 (amino acid 260-279) with simultaneous responses to both peptides in 13% of all subjects tested (n = 97) (p < 0.001).
26	9084973	T-cell proliferation to GAD p17 was higher than to p18 in recent-onset diabetic patients, first degree relatives and unrelated control subjects (p < 0.02, p < 0.004, p < 0.002, respectively).
27	9084973	GAD65 is one of the major autoantigens associated with insulin-dependent diabetes mellitus (IDDM).
28	9084973	The two peptides p17 and p18 of GAD65 that share sequence similarity with coxsackie virus (amino acid sequence identity: PEVKEK) appeared to be the major determinants of GAD65 recognized preferably by T cells from new-onset IDDM patients and their first degree relatives.
29	9084973	In contrast, in our study unrelated control subjects frequently recognized the two GAD peptides (55%, 16/29), similar to first degree relatives (41%, 12/29) and IDDM patients post-onset (68%, 15/22).
30	9084973	Moreover, this study demonstrated a positive correlation of T-cell proliferation to GAD p17 (amino acid 247-266) and p18 (amino acid 260-279) with simultaneous responses to both peptides in 13% of all subjects tested (n = 97) (p < 0.001).
31	9084973	T-cell proliferation to GAD p17 was higher than to p18 in recent-onset diabetic patients, first degree relatives and unrelated control subjects (p < 0.02, p < 0.004, p < 0.002, respectively).
32	9084973	GAD65 is one of the major autoantigens associated with insulin-dependent diabetes mellitus (IDDM).
33	9084973	The two peptides p17 and p18 of GAD65 that share sequence similarity with coxsackie virus (amino acid sequence identity: PEVKEK) appeared to be the major determinants of GAD65 recognized preferably by T cells from new-onset IDDM patients and their first degree relatives.
34	9084973	In contrast, in our study unrelated control subjects frequently recognized the two GAD peptides (55%, 16/29), similar to first degree relatives (41%, 12/29) and IDDM patients post-onset (68%, 15/22).
35	9084973	Moreover, this study demonstrated a positive correlation of T-cell proliferation to GAD p17 (amino acid 247-266) and p18 (amino acid 260-279) with simultaneous responses to both peptides in 13% of all subjects tested (n = 97) (p < 0.001).
36	9084973	T-cell proliferation to GAD p17 was higher than to p18 in recent-onset diabetic patients, first degree relatives and unrelated control subjects (p < 0.02, p < 0.004, p < 0.002, respectively).