Ignet

Gene Information

Gene symbol: POR

Gene name: P450 (cytochrome) oxidoreductase

HGNC ID: 9208

Synonyms: CYPOR, FLJ26468

Related Genes

#	Gene Symbol	Number of hits
1	AR	1 hits
2	CYP17A1	1 hits
3	CYP21A2	1 hits
4	CYP2B6	1 hits
5	CYP3A5	1 hits
6	FMN1	1 hits
7	HMBS	1 hits
8	IHH	1 hits
9	INS	1 hits
10	LSR	1 hits
11	NOS1	1 hits
12	NQO1	1 hits
13	PER1	1 hits
14	TBXAS1	1 hits

Related Sentences

#	PMID	Sentence
1	2777866	At 5 years, CPR, LSR and cumulative survival were 50%, 79.4% and 71.6% respectively.
2	2777866	Post-operative smoking habits were strongly related to CPR and LSR.
3	2777866	At 5 years, CPR, LSR and cumulative survival were 50%, 79.4% and 71.6% respectively.
4	2777866	Post-operative smoking habits were strongly related to CPR and LSR.
5	2888626	The inhibition of imipramine metabolism by anti-cytochrome P-450 reductase antibodies led to the conclusion that cytochrome P-450-dependent monooxygenases are not involved in the N-oxidation of imipramine.
6	3113478	The residual catalytic activity resistant to antibody inhibition may be a reflection of the inaccessibility of a certain amount of cytochrome P-450j due to interference by NADPH-cytochrome P-450 reductase based on results obtained with the reconstituted system.
7	3300683	Similar procedures were used to analyze the distribution of cytochrome P-450 molecules along intracellular membranes; however, special labeling techniques were necessary for this quantification in the electron microscope.
8	3300683	Immunoenzyme cytochemically stained secretions can also be studied morphometrically, and microdensitometry and microfluorometry can also be used to quantify immunocytochemical reactions, as is shown in the analysis of the intralobular distribution of NADPH-cytochrome P-450 reductase in the rat liver.
9	3308889	Responses to insulin by two forms of rat hepatic microsomal cytochrome P-450 that undergo major (RLM6) and minor (RLM5b) elevations in diabetes.
10	3308889	Total cytochrome P-450 levels rise in diabetic rats.
11	3308889	Two specific forms of cytochrome P-450 that are elevated have been isolated from liver microsomes of streptozotocin-induced idabetic male rats.
12	3308889	One enzyme, termed RLM6, metabolizes aniline and acetol, but not testosterone, in a reconstituted system with NADPH-cytochrome P-450 reductase.
13	3308889	Polyclonal antibodies to RLM6 recognized most other forms of cytochrome P-450 in Western blots, but could be made monospecific by adsorption to cross-reacting proteins coupled to Sepharose 4B.
14	3308889	The other form of cytochrome P-450, RLM5b, does not metabolize aniline and only poorly metabolizes acetol and testosterone.
15	6217856	This azoreductase activity was inhibited by cyanide and cytochrome b5 antibody, but was resistant to carbon monoxide and SKF-525A (beta-diethylaminoethyl-diphenylpropylacetate). 2.
16	6217856	Azoreductase activity, NADPH-cytochrome P-450 reductase, cytochromes P-450 and b5 were measured in liver microsomes prepared from fasted animals and from animals treated with 20-methylcholanthrene, phenobarbital, streptozotocin or 3-aminotriazole plus allyl-isopropylacetamide.
17	6217856	No direct correlation could be established between the variations of azoreductase activity and those of cytochromes P-450 and b5, and of NADPH-cytochrome P-450 reductase in these experimental situations.
18	6217856	This azoreductase activity was inhibited by cyanide and cytochrome b5 antibody, but was resistant to carbon monoxide and SKF-525A (beta-diethylaminoethyl-diphenylpropylacetate). 2.
19	6217856	Azoreductase activity, NADPH-cytochrome P-450 reductase, cytochromes P-450 and b5 were measured in liver microsomes prepared from fasted animals and from animals treated with 20-methylcholanthrene, phenobarbital, streptozotocin or 3-aminotriazole plus allyl-isopropylacetamide.
20	6217856	No direct correlation could be established between the variations of azoreductase activity and those of cytochromes P-450 and b5, and of NADPH-cytochrome P-450 reductase in these experimental situations.
21	7514568	The similarity of sequence and cofactor binding sites has suggested that the NOS genes may also be related to cytochrome P450 reductase, as well as to plant and bacterial oxidoreductases.
22	7514568	Identification of the human gene for endothelial NOS (NOS3) was confirmed by nucleotide sequence analysis of the first coding exon, which was found to be identical to its cognate cDNA.
23	7742795	Effect of ferritin on lambda DNA strand breaks in the reaction system of alloxan plus NADPH-cytochrome P450 reductase: ferritin's role in diabetogenic action of alloxan.
24	7742795	The incubation of lambda DNA in the reaction system of alloxan plus NADPH-cytochrome P450 reductase (fp2) in the presence of ferritin caused strand breaks after a lag time of about 5 min.
25	7742795	Catalase, scavengers of hydroxyl radicals (HO.) and iron-chelators almost completely inhibited the DNA strand breaks, but superoxide dismutase (SOD) did not, suggesting that the strand breaks are induced by the generation of HO. via the reaction of H2O2 and Fe(II), namely, the Fenton reaction.
26	7742795	Effect of ferritin on lambda DNA strand breaks in the reaction system of alloxan plus NADPH-cytochrome P450 reductase: ferritin's role in diabetogenic action of alloxan.
27	7742795	The incubation of lambda DNA in the reaction system of alloxan plus NADPH-cytochrome P450 reductase (fp2) in the presence of ferritin caused strand breaks after a lag time of about 5 min.
28	7742795	Catalase, scavengers of hydroxyl radicals (HO.) and iron-chelators almost completely inhibited the DNA strand breaks, but superoxide dismutase (SOD) did not, suggesting that the strand breaks are induced by the generation of HO. via the reaction of H2O2 and Fe(II), namely, the Fenton reaction.
29	8294080	These isoforms are regulated by Ca(2+)-calmodulin with NADPH, FAD/FMN and tetrahydrobiopterin as co-factors and reveal a high degree of homology with the amino-acid sequence of cytochrome P450 reductase within the C-terminal domain.
30	8825678	Induction and suppression of renal and hepatic cytochrome P450-dependent monooxygenases by acute and chronic streptozotocin diabetes in hamsters.
31	8825678	Total cytochrome P450 content and NADPH-cytochrome P450 reductase activity in kidney and liver microsomes of the diabetic hamsters were similar to the controls.
32	9114822	The MEOS was purified and reconstituted using 2E1, phospholipids, and cytochrome P-450 reductase and shown to oxidize ethanol to acetaldehyde, mainly as a monooxygenase and secondarily via hydroxyl radicals, with transcriptional and posttranscriptional regulation.
33	9287058	Animals were exposed to one of three protocols distinguished by the site of glucose infusion: POR(UPS), POR(ADJ), or peripheral (PER).
34	9287058	By design, hepatic glucose was significantly elevated during POR(UPS) and POR(ADJ) versus PER (4.3 +/- 0.1 vs. 2.4 +/- 0.1 mmol/l, respectively; P < 0.05).
35	9287058	When portohepatic normoglycemia was maintained during POR(UPS), a 67% suppression in the epinephrine response versus that during PER was observed (P < 0.001).
36	9287058	While both POR(UPS) and POR(ADJ) yielded elevated liver glycemia in the face of systemic hypoglycemia, only POR(UPS) yielded an elevated portal vein glucose concentration.
37	9287058	That only POR(UPS) resulted in a significant suppression of the sympathoadrenal response is consistent with the localization of the glucosensors to the portal vein.
38	9287058	Animals were exposed to one of three protocols distinguished by the site of glucose infusion: POR(UPS), POR(ADJ), or peripheral (PER).
39	9287058	By design, hepatic glucose was significantly elevated during POR(UPS) and POR(ADJ) versus PER (4.3 +/- 0.1 vs. 2.4 +/- 0.1 mmol/l, respectively; P < 0.05).
40	9287058	When portohepatic normoglycemia was maintained during POR(UPS), a 67% suppression in the epinephrine response versus that during PER was observed (P < 0.001).
41	9287058	While both POR(UPS) and POR(ADJ) yielded elevated liver glycemia in the face of systemic hypoglycemia, only POR(UPS) yielded an elevated portal vein glucose concentration.
42	9287058	That only POR(UPS) resulted in a significant suppression of the sympathoadrenal response is consistent with the localization of the glucosensors to the portal vein.
43	9287058	Animals were exposed to one of three protocols distinguished by the site of glucose infusion: POR(UPS), POR(ADJ), or peripheral (PER).
44	9287058	By design, hepatic glucose was significantly elevated during POR(UPS) and POR(ADJ) versus PER (4.3 +/- 0.1 vs. 2.4 +/- 0.1 mmol/l, respectively; P < 0.05).
45	9287058	When portohepatic normoglycemia was maintained during POR(UPS), a 67% suppression in the epinephrine response versus that during PER was observed (P < 0.001).
46	9287058	While both POR(UPS) and POR(ADJ) yielded elevated liver glycemia in the face of systemic hypoglycemia, only POR(UPS) yielded an elevated portal vein glucose concentration.
47	9287058	That only POR(UPS) resulted in a significant suppression of the sympathoadrenal response is consistent with the localization of the glucosensors to the portal vein.
48	9287058	Animals were exposed to one of three protocols distinguished by the site of glucose infusion: POR(UPS), POR(ADJ), or peripheral (PER).
49	9287058	By design, hepatic glucose was significantly elevated during POR(UPS) and POR(ADJ) versus PER (4.3 +/- 0.1 vs. 2.4 +/- 0.1 mmol/l, respectively; P < 0.05).
50	9287058	When portohepatic normoglycemia was maintained during POR(UPS), a 67% suppression in the epinephrine response versus that during PER was observed (P < 0.001).
51	9287058	While both POR(UPS) and POR(ADJ) yielded elevated liver glycemia in the face of systemic hypoglycemia, only POR(UPS) yielded an elevated portal vein glucose concentration.
52	9287058	That only POR(UPS) resulted in a significant suppression of the sympathoadrenal response is consistent with the localization of the glucosensors to the portal vein.
53	9287058	Animals were exposed to one of three protocols distinguished by the site of glucose infusion: POR(UPS), POR(ADJ), or peripheral (PER).
54	9287058	By design, hepatic glucose was significantly elevated during POR(UPS) and POR(ADJ) versus PER (4.3 +/- 0.1 vs. 2.4 +/- 0.1 mmol/l, respectively; P < 0.05).
55	9287058	When portohepatic normoglycemia was maintained during POR(UPS), a 67% suppression in the epinephrine response versus that during PER was observed (P < 0.001).
56	9287058	While both POR(UPS) and POR(ADJ) yielded elevated liver glycemia in the face of systemic hypoglycemia, only POR(UPS) yielded an elevated portal vein glucose concentration.
57	9287058	That only POR(UPS) resulted in a significant suppression of the sympathoadrenal response is consistent with the localization of the glucosensors to the portal vein.
58	10615943	By design, portal vein glucose concentrations were significantly elevated during POR versus PER (4.4+/-0.14 vs. 2.5+/-0.07 mmol/l; P<0.01, respectively) for both PDN and SHAM.
59	10802147	Since the CPR levels become much higher than the concentration of C-peptide for several reasons, such as the high concentration of proinsulin, CPR values sometimes need to be assessed carefully.
60	12044959	The mechanism of dissociation of cortisol and DHEA synthesis in aging depends on another regulator of 17,20-lyase of cytochrome P450c17 such as cytochrome P450 reductase.
61	12044959	We demonstrated significant decrease in cytochrome P450 reductase activity in bovine aged adrenal glands.
62	12044959	We clarified the conversion of DHEA to estrone by cytochrome P450 aromatase in primary cultured human osteoblasts.
63	12044959	The mechanism of dissociation of cortisol and DHEA synthesis in aging depends on another regulator of 17,20-lyase of cytochrome P450c17 such as cytochrome P450 reductase.
64	12044959	We demonstrated significant decrease in cytochrome P450 reductase activity in bovine aged adrenal glands.
65	12044959	We clarified the conversion of DHEA to estrone by cytochrome P450 aromatase in primary cultured human osteoblasts.
66	19264869	P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol- and Indian Hedgehog-dependent mechanisms.
67	19264869	Cytochrome P450 oxidoreductase (POR) is the electron donor for microsomal cytochrome P450 enzymes and other non-P450 enzymes.
68	19264869	Because cholesterol is required for normal activity of the hedgehog proteins, we evaluated the effects of POR siRNAs on the expression of Indian hedgehog (Ihh), an important regulator of chondrogenesis.
69	19264869	POR siRNA-transfected chondrocytes exhibited reduced Ihh expression, with such effect being neutralized by cholesterol.
70	19264869	Lastly, recombinant human/mouse Ihh prevented the POR siRNA-mediated effects on chondrocyte proliferation, differentiation, and apoptosis.
71	19264869	Our findings suggest that the bone malformations associated with defective POR activity are due to reduced cholesterol synthesis and, in turn, reduced Ihh expression in chondrocytes.
72	19264869	P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol- and Indian Hedgehog-dependent mechanisms.
73	19264869	Cytochrome P450 oxidoreductase (POR) is the electron donor for microsomal cytochrome P450 enzymes and other non-P450 enzymes.
74	19264869	Because cholesterol is required for normal activity of the hedgehog proteins, we evaluated the effects of POR siRNAs on the expression of Indian hedgehog (Ihh), an important regulator of chondrogenesis.
75	19264869	POR siRNA-transfected chondrocytes exhibited reduced Ihh expression, with such effect being neutralized by cholesterol.
76	19264869	Lastly, recombinant human/mouse Ihh prevented the POR siRNA-mediated effects on chondrocyte proliferation, differentiation, and apoptosis.
77	19264869	Our findings suggest that the bone malformations associated with defective POR activity are due to reduced cholesterol synthesis and, in turn, reduced Ihh expression in chondrocytes.
78	19264869	P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol- and Indian Hedgehog-dependent mechanisms.
79	19264869	Cytochrome P450 oxidoreductase (POR) is the electron donor for microsomal cytochrome P450 enzymes and other non-P450 enzymes.
80	19264869	Because cholesterol is required for normal activity of the hedgehog proteins, we evaluated the effects of POR siRNAs on the expression of Indian hedgehog (Ihh), an important regulator of chondrogenesis.
81	19264869	POR siRNA-transfected chondrocytes exhibited reduced Ihh expression, with such effect being neutralized by cholesterol.
82	19264869	Lastly, recombinant human/mouse Ihh prevented the POR siRNA-mediated effects on chondrocyte proliferation, differentiation, and apoptosis.
83	19264869	Our findings suggest that the bone malformations associated with defective POR activity are due to reduced cholesterol synthesis and, in turn, reduced Ihh expression in chondrocytes.
84	19264869	P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol- and Indian Hedgehog-dependent mechanisms.
85	19264869	Cytochrome P450 oxidoreductase (POR) is the electron donor for microsomal cytochrome P450 enzymes and other non-P450 enzymes.
86	19264869	Because cholesterol is required for normal activity of the hedgehog proteins, we evaluated the effects of POR siRNAs on the expression of Indian hedgehog (Ihh), an important regulator of chondrogenesis.
87	19264869	POR siRNA-transfected chondrocytes exhibited reduced Ihh expression, with such effect being neutralized by cholesterol.
88	19264869	Lastly, recombinant human/mouse Ihh prevented the POR siRNA-mediated effects on chondrocyte proliferation, differentiation, and apoptosis.
89	19264869	Our findings suggest that the bone malformations associated with defective POR activity are due to reduced cholesterol synthesis and, in turn, reduced Ihh expression in chondrocytes.
90	19264869	P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol- and Indian Hedgehog-dependent mechanisms.
91	19264869	Cytochrome P450 oxidoreductase (POR) is the electron donor for microsomal cytochrome P450 enzymes and other non-P450 enzymes.
92	19264869	Because cholesterol is required for normal activity of the hedgehog proteins, we evaluated the effects of POR siRNAs on the expression of Indian hedgehog (Ihh), an important regulator of chondrogenesis.
93	19264869	POR siRNA-transfected chondrocytes exhibited reduced Ihh expression, with such effect being neutralized by cholesterol.
94	19264869	Lastly, recombinant human/mouse Ihh prevented the POR siRNA-mediated effects on chondrocyte proliferation, differentiation, and apoptosis.
95	19264869	Our findings suggest that the bone malformations associated with defective POR activity are due to reduced cholesterol synthesis and, in turn, reduced Ihh expression in chondrocytes.
96	19264869	P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol- and Indian Hedgehog-dependent mechanisms.
97	19264869	Cytochrome P450 oxidoreductase (POR) is the electron donor for microsomal cytochrome P450 enzymes and other non-P450 enzymes.
98	19264869	Because cholesterol is required for normal activity of the hedgehog proteins, we evaluated the effects of POR siRNAs on the expression of Indian hedgehog (Ihh), an important regulator of chondrogenesis.
99	19264869	POR siRNA-transfected chondrocytes exhibited reduced Ihh expression, with such effect being neutralized by cholesterol.
100	19264869	Lastly, recombinant human/mouse Ihh prevented the POR siRNA-mediated effects on chondrocyte proliferation, differentiation, and apoptosis.
101	19264869	Our findings suggest that the bone malformations associated with defective POR activity are due to reduced cholesterol synthesis and, in turn, reduced Ihh expression in chondrocytes.
102	20126370	With DHEA treatment, cytosolic malate dehydrogenase activities were significantly increased by ~5 fold and glucose 6-phosphate dehydrogenase activities were decreased by ~25% compared to carcinogen treated group.
103	20126370	However, liver microsomal cytochrome P-450 content and NADPH-dependent cytochrome P-450 reductase activities were not altered with DHEA treatment.
104	20126370	However, vitamin E did not alter glucose 6-phosphate dehydrogenase or malate dehydrogenase activities.
105	20410220	Concomitant mutations in the P450 oxidoreductase and androgen receptor genes presenting with 46,XY disordered sex development and androgenization at adrenarche.
106	20417277	Our recent foci have been on P450 oxidoreductase deficiency (ORD) and apparent cortisone reductase deficiency (ACRD).
107	21190981	Pubertal presentation in seven patients with congenital adrenal hyperplasia due to P450 oxidoreductase deficiency.
108	21874273	In his career this investigator has been involved in the study of many steroid disorders, the two most recent being P450 oxidoreductase deficiency and apparent cortisone reductase deficiency.
109	22162478	Genotype-phenotype analysis in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency.
110	23044879	Furthermore the description of nonclassical lipoid CAH and the protean manifestations of P450 oxidoreductase (POR) deficiencies has expanded the spectrum of human disease caused by disordered steroidogenesis.
111	23365120	Prenatal diagnosis of congenital adrenal hyperplasia caused by P450 oxidoreductase deficiency.
112	12435796	Liver X receptor (LXR) alpha and LXRbeta are nuclear oxysterol receptors whose biological function has so far been elucidated only with respect to cholesterol and lipid metabolism.
113	12435796	Notably, LXR agonist treatment up-regulated CYP4A10 and CYP4A14 together with cytochrome P450 reductase, indicating a possible enhancement of microsomal lipid peroxidation.