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Gene Information
Gene symbol: PPP1R8
Gene name: protein phosphatase 1, regulatory subunit 8
HGNC ID: 9296
Synonyms: ard-1, NIPP-1, PRO2047, ARD1, NIPP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PPP1CA | 1 hits |
| 2 | PPP1R3C | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17082262 | Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells. |
| 2 | 17082262 | In this study, we propose that glucose-induced stimulation of overall translation in beta-cells depends on a protein phosphatase-1-mediated decrease in serine-51 phosphorylation of eukaryotic translation initiation factor 2alpha (eIF2alpha), a pivotal translation initiation factor. |
| 3 | 17082262 | Experiments with salubrinal on intact cells and nuclear inhibitor of protein phosphatase-1 (PP1) on cell extracts suggested that this phosphatase was PP1. |
| 4 | 17082262 | Thus, the steady-state level of eIF2alpha phosphorylation in beta-cells is the result of a balance between folding-load-induced phosphorylation and PP1-dependent dephosphorylation. |