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Gene Information
Gene symbol: PPP2R5B
Gene name: protein phosphatase 2, regulatory subunit B', beta
HGNC ID: 9310
Synonyms: FLJ35411, B56B, PR61B
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | PPP2R4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19249087 | A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. |
| 2 | 19249087 | With striking conservation, mammalian B56beta regulates Akt phosphorylation at Thr 308 in 3T3-L1 adipocytes. |
| 3 | 19249087 | This study reveals a conserved role for the B56 regulatory subunit in regulating insulin signaling through AKT dephosphorylation, thereby having widespread implications in cancer and diabetes research. |
| 4 | 19901535 | InAKTivation of insulin/IGF-1 signaling by dephosphorylation. |
| 5 | 19901535 | One such example is the C. elegans PP2A regulatory subunit PPTR-1 that negatively regulates the insulin/insulin-like growth factor signaling pathway to modulate longevity, dauer diapause, fat metabolism and stress resistance. |
| 6 | 19901535 | PPTR-1, as well as its mammalian homolog B56beta, specifically target the PP2A enzyme to AKT and mediate the dephosphorylation of this important kinase at a conserved threonine residue. |