Ignet

Gene Information

Gene symbol: PRDX6

Gene name: peroxiredoxin 6

HGNC ID: 16753

Synonyms: AOP2, KIAA0106, 1-Cys, NSGPx, PRX, aiPLA2, MGC46173, p29

Related Genes

#	Gene Symbol	Number of hits
1	ADIPOQ	1 hits
2	AKR1B1	1 hits
3	ALB	1 hits
4	ALDH1A1	1 hits
5	ANXA5	1 hits
6	CAT	1 hits
7	CES1	1 hits
8	FABP4	1 hits
9	FAH	1 hits
10	GPX1	1 hits
11	GSTCD	1 hits
12	GSTP1	1 hits
13	GTF2A1	1 hits
14	HMGB1	1 hits
15	HSP90AB1	1 hits
16	HSPA9	1 hits
17	HSPB1	1 hits
18	LDHB	1 hits
19	OGN	1 hits
20	PLIN	1 hits
21	PRDX4	1 hits
22	RPS27A	1 hits
23	SELENBP1	1 hits
24	SERPINA1	1 hits
25	TEGT	1 hits
26	TF	1 hits
27	TXN	1 hits
28	TXN2	1 hits
29	USP11	1 hits
30	VCL	1 hits

Related Sentences

#	PMID	Sentence
1	10588361	A peroxidase from yeast that reduces H2O2 with the use of electrons provided by thioredoxin (Trx) together with homologs from a wide variety of species constitute the peroxiredoxin (Prx) family of proteins.
2	10588361	With the use of recombinant proteins, Prx I, II, and III have now been shown to possess peroxidase activity and to rely on Trx as a source of reducing equivalents.
3	10588361	These results suggest that, together with glutathione peroxidase and catalase, Prx enzymes likely play an important role in eliminating peroxides generated during metabolism as well as during stimulation of cell surface receptors.
4	10588361	A peroxidase from yeast that reduces H2O2 with the use of electrons provided by thioredoxin (Trx) together with homologs from a wide variety of species constitute the peroxiredoxin (Prx) family of proteins.
5	10588361	With the use of recombinant proteins, Prx I, II, and III have now been shown to possess peroxidase activity and to rely on Trx as a source of reducing equivalents.
6	10588361	These results suggest that, together with glutathione peroxidase and catalase, Prx enzymes likely play an important role in eliminating peroxides generated during metabolism as well as during stimulation of cell surface receptors.
7	10588361	A peroxidase from yeast that reduces H2O2 with the use of electrons provided by thioredoxin (Trx) together with homologs from a wide variety of species constitute the peroxiredoxin (Prx) family of proteins.
8	10588361	With the use of recombinant proteins, Prx I, II, and III have now been shown to possess peroxidase activity and to rely on Trx as a source of reducing equivalents.
9	10588361	These results suggest that, together with glutathione peroxidase and catalase, Prx enzymes likely play an important role in eliminating peroxides generated during metabolism as well as during stimulation of cell surface receptors.
10	14751239	Polyol pathway-dependent osmotic and oxidative stresses in aldose reductase-mediated apoptosis in human lens epithelial cells: role of AOP2.
11	15039483	Interestingly, several thiol antioxidative genes (glutathione peroxidase 1, peroxiredoxin 6, and thioredoxin 2) were found by microarray and confirmed by real-time PCR to be upregulated by high glucose.
12	22684688	Peroxiredoxin (Prx)-4, a secretable endoplasmic reticulum (ER)-resident isoform of the mammalian Prx family, functions as a thioredoxin-dependent peroxidase.
13	22736268	Proteomic profiling of differentially expressed proteins from Bax inhibitor-1 knockout and wild type mice.
14	22736268	Bax inhibitor-1 (BI-1) is an anti-apoptotic protein located in the endoplasmic reticulum (ER).
15	22736268	In several bi-1 (-/-) mice, glucose-regulated protein 75 (GRP75/mortalin/ PBP74/mthsp70), peroxiredoxin6 (Prx6) and fumarylacetoacetate hydrolase (FAH) showed a pI shift that could be attributed to post-translational modifications.
16	22736268	Selenium-binding protein 2 (SBP2) and ferritin light chain 1 levels were significantly increased.
17	22736268	Phosphatidylethanolamine-binding protein-1 (PEBP-1) was dramatically decreased in bi-1 (-/-) mice, which was confirmed by Western blotting.
18	22736268	The phosphorylation of GRP75, Prx6 and FAH were compared between bi-1 (+/+) and bi-1 (-/-) mice using liver tissue lysates.
19	22796336	Compared with non-obese subjects, obese patients presented with increased carboxylesterase-1, zinc finger protein 324A, annexin A5, ubiquitin carboxyl-terminal hydrolase, α-crystallin B chain, osteoglycin, retinal dehydrogenase-1 and 14-3-3 protein γ, and decreased transferrin, complement C3, fibrinogen γ chain, albumin, α1-antitrypsin and peroxiredoxin-6, irrespective of the adipose tissue depot studied.
20	22796336	SAT and VAT differed in protein species of fibrinogen and osteoglycin, whereas adipose tissue depot and obesity interacted on the protein abundance of actin, α-actinin 1, one protein species of carboxylesterase-1, retinal dehydrogenase-1 and 14-3-3 protein γ.
21	23709000	GDM was associated with an up-regulation of four proteins: collagen alpha-2(VI) chain (CO6A2 (COL6A2)), fibrinogen beta chain (FIBB (FGB)), lumican (LUM) and S100A9.
22	23709000	These were alpha-1-antitrypsin (AIAT (SERPINA 1)), annexin A5 (ANXA5), fatty acid-binding protein, adipocyte (FABP4), glutathione S-transferase P (GSTP (GSTP1)), heat-shock protein beta-1 (HSP27 (HSPB1)), lactate dehydrogenase B chain (LDHB), perilipin-1 (PLIN1), peroxiredoxin-6 (PRX6 (PRDX6)), selenium-binding protein 1 (SBP1) and vinculin (VINC (VCL)).