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Gene Information
Gene symbol: PRICKLE1
Gene name: prickle homolog 1 (Drosophila)
HGNC ID: 17019
Synonyms: FLJ31937, EPM1B
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | JUNB | 1 hits |
| 2 | MAP3K2 | 1 hits |
| 3 | RHOA | 1 hits |
| 4 | RNF123 | 1 hits |
| 5 | SMAD1 | 1 hits |
| 6 | SMURF1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21454619 | The HECT-type ubiquitin ligase (E3) Smad ubiquitination regulatory factor 1 (Smurf1) targets various substrates, including Smad1/5, RhoA, Prickle 1, MEKK2, and JunB for degradation and thereby regulates adult bone formation and embryonic development. |
| 2 | 21454619 | Here, we identify the endoplasmic reticulum (ER)-localized Wolfram syndrome protein (WFS1) as a specific degradation substrate of Smurf1. |
| 3 | 21454619 | We show that Smurf1 interacts with WFS1 at the ER and promotes the ubiquitination and proteasomal degradation of WFS1. |
| 4 | 21454619 | By contrast, pathophysiological deletion mutants of WFS1 lacking the degron, such as W648X, Y660X, and Q667X, are resistant to degradation by Smurf1. |
| 5 | 21454619 | Depletion of Smurf1 by RNA interference results in increased WFS1 and decreased ATF6α levels. |
| 6 | 21454619 | Furthermore, we show that ER stress induces Smurf1 degradation and WFS1 up-regulation. |